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Partha Pratim Datta

PhD:
Molecular Biology, (IICB / Jadavpur University, 2002)
Area of Interest:
Structural & Molecular Biology
Email ID:
partha_datta
Research Interest:
  • Studies on the mechanisms of protein synthesis and molecular basis of stress response in prokaryotes.
  • Structural and functional analysis of cellular macromolecular complexes by Cryo-Electron Microscopy, 3D Image processing and molecular biological methods.
Academic Qualification:
  • Ph.D. (Molecular Biology), Indian Institute of Chemical Biology, Jadavpur University, 2002.
  • M.Sc. (Biotechnology), Madurai Kamaraj University, 1995.

  • Positions:
  • Post-Doctoral Researcher - Wadsworth Center, Albany, NY, USA (Oct, 2001 - Aug, 2008)
  • Research Scientist  - Wadsworth Center, Albany, NY, USA (Aug, 2008 – Nov, 2009)
  • Assistant Professor - Indian Institute of Science Education and Research-Kolkata (Dec, 2009 - )
  • Awards and Honors:

    2007: Robert J. Colinas Award for Outstanding Postdoctoral Research, Wadsworth Center, NY, USA.

    2000: Young Scientist Award, in the 5th International Conference on Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases, Hyderabad, India.

    1996- 2001: National Eligibility Test Research Fellowship, Council of Scientific and Industrial Research, India.

    1993- 1995: Junior Fellow Scholarship in Biochemistry, Indian Council of Agricultural Research, India.

    1986 -1992: National Merit Scholarship, Govt. of India.

    List of Publications:
    • Chatterjee, A., and Datta, P.P. (2015). Two conserved amino acids of juxtaposed domains of a ribosomal maturation protein CgtA sustain its optimal GTPase activity. Biochem. Biophys. Res. Commun., 461(4):636-41.
    • Datta, P.P., and Chatterjee, A. (2013) A passage through the ribosome by Cryo-EM.  in Biophysical approaches to translational control of gene expression. Series: Biophysics for the Life Sciences, Vol. 1, Springer, 2013.
    • Yassin, A.S., Haque, M.E., Datta, P.P., Elmore, K., Banavali, N.K., Spremulli, L.L., Agrawal , R.K. (2011). Insertion domain within mammalian mitochondrial translation initiation factor 2 serves the role of eubacterial initiation factor 1. Proc. Natl. Acad. Sci. (USA), 108(10), 3918-23.
    • Sharma, M.R., Dönhöfe, A., Barat, C., Marquez, V., Datta, P.P., Fucini, P., Wilson, D.N., and Agrawal, R.K. (2010). PSRP1 is not a ribosomal protein, but a ribosome-binding factor that is recycled by the ribosome-recycling factor (RRF) and elongation factor G (EF-G). J. Biol. Chem, 285(6), 4006-4014.
    • Dönhöfer, A., Sharma, M.R., Datta, P.P., Nierhaus, K.H., Agrawal, R.K., and Wilson, D.N. (2009). Factor-Mediated Ribosome Assembly in Bacteria: Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester
    • Gaur, R, Grasso, D, Datta, P.P., Krishna, P.D.V., Das, G., Spencer, A., Agrawal, R.K., Spremulli, L., and Varshney, U. (2008). A single mammalian mitochondrial translation initiation factor functionally replaces two bacterial factors. Mol. Cell, 29, 180-190. [The structural biological work appeared on the cover-page of the Translational Control Meeting book, (2008) Cold Spring Harbor Laboratory, NY, USA]
    • Sharma, M.R., Wilson, D.N., Datta, P.P., Barat, C., Fucini, P., and Agrawal, R.K., (2007). Cryo-EM structure of the Spinacea oleracea chloroplast 70S ribosome suggests functional roles for plastid-specific ribosomal proteins. Proc. Natl. Acad. Sci. (USA), 104, 19315-19320.
    • Datta, P.P., Wilson, D.N., Kawazoe, M., Swami, N.K., Sharma, M.R., Booth, T., Shirouzu, M., Takemoto, C.,Fucini, P., and Agrawal, R.K. (2007). Cryo-EM reveals the structural aspects of RbfA function. Mol. Cell, 28, 434-445. [News article, RIKEN Research, Japan]
    • Barat, C*., Datta, P.P*., Raj, V.S., Sharma, M.R., Kaji, H., Kaji, A., and Agrawal, R.K. (2007). Progression of the RRF through the ribosome dissociates the ribosomal subunit. Mol. Cell, 27, 250-261. (*co -first authors).
    • Datta, P.P., Sharma, M.R., Qi, L., Frank, J. and Agrawal, R.K. (2005). Interaction of the G’ domain of elongation factor G and the C-terminal domain of ribosomal Protein L7/L12 during translocation, as revealed by cryo-EM. Mol. Cell, 20, 723-731. [Comments on Faculty of 1000]
    • Palenzuela, L., Hahn, N.M., Nelson Jr., R.P., Arno, J.N., Schobert, C., Bethel, R., Ostrowski, L.A., Sharma, M.R., Datta, P.P., Agrawal, R.K. Schwartz, J. E., and Hirano, M. (2005). Does Linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis? Clin. Infect. Dis., 40, e113-116.
    • Datta, P.P., and Bhadra R.K. (2003). Cold shock response and major cold shock proteins of Vibrio cholerae. Appl. Environ. Microbiol., 69, 6361-6369.
    • Sharma, M.R., Koc, E.C., Datta, P.P., Booth, T., Spremulli, L.L., and Agrawal, R.K. (2003). Structure of the mammalian mitochondrial ribosome reveals an expanded functional role for its component proteins. Cell, 115, 97-108.