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Nirmalya Ghosh

PhD:
Physics (RRCAT, Indore, 2005)
Area of Interest:
Optics & Spectroscopy, Biophotonics
Email ID:
nghosh
Research Interest:

Our research activity is mainly in the area of experimental optics and spectroscopy with special emphasis on biomedical optics and spectroscopy (biophotonics).

Specifically

(i)                 Investigate various optical spectroscopic approaches (Elastic scattering, Fluorescence, Raman) for probing biological systems and other complex systems. Evaluate the use of multimodal spectroscopy for early diagnosis of disease.

(ii)               Develop novel optical modalities (based on the principle of coherence gating, time gating and polarization gating) for imaging through turbid medium. Explore the use of these approaches for biomedical imaging.

(iii)             Basic theoretical and experimental studies on polarization (Mueller matrices, Stokes vectors, Jones matrices) and coherence characteristics of scattered light in random medium. Theoretical modeling (Monte Carlo simulations, radiative transport theory, diffusion approximation) of light propagation in random medium.

(iv)

Basic studies on near field optics and spectroscopy. This include studies on the enhancement of local optical fields in presence of nano scale metal structure (surface plasmon resonance), surface enhanced spectroscopy, morphology dependent resonance (whispering gallery modes) effects associated with near field Mie scattering from dielectric particles etc. Utilize the information obtained from these basic studies for ultra-high sensitive bio-sensing and possible diagnostic applications.

Academic Qualification:
  • Ph.D. (Physics), Raja Ramanna Centre for Advanced Technology, India
  • M. Tech. (Laser Technology), IIT Kanpur, India
  • M.Sc. (Physics), University of Kalyani, India
  • B.Sc. (Physics), University of Kalyani, India
  • Positions:
  • Scientist C, Raja Ramanna Centre for Advanced Technology (RRCAT), India (1998 – 2000).
  • Scientist D, Raja Ramanna Centre for Advanced Technology (RRCAT), India (2000 – 2004).
  • Scientist E, Raja Ramanna Centre for Advanced Technology (RRCAT), India (2004 – 2007).
  • Post Doctoral Fellow, University of Toronto, Department of Medical Biophysics, Toronto, Canada (2007- 2009).
  • Assistant Professor, Indian Institute of Science Education and Research, Kolkata, (2009 -).


  • Awards and Honors:


    List of Publications:

    Journal Publications

    1. Jalpa Soni, Harsh Purwar and Nirmalya Ghosh, "Quantitative polarimetry of plasmon resonant spheroidal metal nanoparticles: A Mueller matrix decomposition study", Optics Communications, 285, 1599 - 1607 (2011).
    2. Nirmalya Ghosh and I. Alex Vitkin, “Tissue polarimetry: concepts, challenges, applications and outlook”, Invited review article, Journal of Biomedical Optics, 16, 110801 (2011).
    3. S. Ghosh, J. Soni, H. Purwar, J. Jagtap, A. Pradhan, N. Ghosh and P. K. Panigrahi, “Differing self-similarity in light scattering spectra: a potential tool for pre-cancer detection”, Optics Express, 19 (20), 19717-19730 (2011).
    4. “Turbid medium polarimetry in biomedical imaging and diagnosis”, Nirmalya Ghosh, Ayan Banerjee and Jalpa Soni, Invited review article, Eur. Phys. J. Appl. Phys., 54, 30001 (2011).
    5. “Influence of the order of the constituent basis matrices on the Mueller matrix decomposition-derived polarization parameters in complex turbid media such as biological tissues”, Nirmalya Ghosh, Michael F. G. Wood and I. Alex Vitkin, Optics Communications, 283, 1200 – 1208 (2010).
    6. “Polarimetry-based method to extract geometry-independent metrics of tissue anisotropy”, Marika A. Wallenburg, Michael F. G. Wood, Nirmalya Ghosh and I. Alex Vitkin, Optics Letters, 35, 2570 – 2572 (2010).
    7. “Mueller matrix polarimetry for the characterization of complex random medium”, Nirmalya Ghosh, Jalpa Soni, M. F. G. Wood, M. A. Wallenberg and I. A. Vitkin,  PRAMANA –Journal of Physics, 75 (6), 1071 – 1086 (2010).
    8. “Depolarization of light in turbid media: a scattering event resolved Monte Carlo study”, Xinxin Guo, Michael F. G. Wood, Nirmalya Ghosh, and I. Alex Vitkin, Applied Optics, 49 (2), 153-162 (2010). [Virtual Journal of Biomedical Optics, 5 (3), 2010].
    9. “Polarization birefringence measurements for characterizing the myocardium, including healthy, infracted, and stem cell treated regenerating cardiac tissues”, Michael F. G. Wood, Nirmalya Ghosh, Marika A. Wallenburg, Shu-Hong Li, Richard D. Weisel, Brian C. Wilson, Ren-Ki Li, and I. Alex Vitkin, Journal of Biomedical Optics, 15 (4), 047009 (2010).
    10. “Comparison of optical polarimetry and diffusion tensor MR imaging for assessing myocardial anisotropy”, Marika A. Wallenburg, Mihaela Pop, Michael F. G. Wood, Nirmalya Ghosh, Graham A. Wright and I. Alex Vitkin, Journal of Innovative Optical Health Sciences, 3(2), 109-121 (2010).
    11. “Polarimetry in turbid, birefringent, optically active media: a Monte Carlo study of Mueller matrix decomposition in the backscattering geometry”, Nirmalya Ghosh, Michael F G Wood, I Alex Vitkin, Journal of Applied Physics, 105 (10), 102023-102023-8 (2009).
    12. “Mueller matrix decomposition for polarized light assessment of biological tissues”, Nirmalya Ghosh, Michael F. G. Wood, Shu-hong Li, Richard D. Weisel, Brian C. Wilson, Ren-Ke Li, and I. Alex Vitkin, Journal of Biophotonics, 2, 145 – 156 (2009).
    13. “Proof-of-principle demonstration of a Mueller matrix decomposition method for polarized light tissue characterization in vivo”, Michael F. G. Wood, Nirmalya Ghosh, Eduardo H. Moriyama, Brian C. Wilson, and I. Alex Vitkin, Journal of Biomedical Optics, 14, 014029(2009).
    14. “Polarized diffuse reflectance measurements on cancerous and noncancerous tissues”, S. Manhas, M. K. Swami, H. S. Patel, A. Uppal, N. Ghosh and P. K. Gupta, J. Biophotonics, 2, 581-587 (2009).
    15. “Mueller matrix decomposition for extraction of individual polarization parameters from complex turbid media exhibiting multiple scattering, optical activity and linear birefringence”, Nirmalya Ghosh, Michael F G Wood, I Alex Vitkin, Journal of Biomedical Optics, 13, 044036 (2008).
    16. “Simultaneous determination of size and refractive index of red blood cells by light scattering measurements”, N. Ghosh, P. Buddhiwant, A. Uppal, S.K. Majumder, H.S. Patel and P.K. Gupta, Applied Physics Letters, 88, 084101 (2006).
    17. “Anomalous behavior of depolarization of light in a turbid medium”, N. Ghosh, P.K. Gupta, A. Pradhan, S.K. Majumder, Physics Letters A, 354, 236 – 242 (2006).
    18. “Polar decomposition of 3 ´ 3 Mueller matrix: a tool for quantitative tissue polarimetry”, M.K. Swami, S. Manhas, P. Buddhiwant, N. Ghosh, A. Uppal and P.K. Gupta, Optics Express, 14, 9324 – 9337 (2006).
    19. “Mueller matrix approach for determination of optical rotation in chiral turbid media in backscattering geometry”, S. Manhas, M.K. Swami, P. Buddhiwant, N. Ghosh, P.K. Gupta and K. Singh, Optics Express, 14, 190 – 202 (2006).
    20. Multi-class classification algorithm for optical diagnosis of oral cancer; S.K. Majumder, A. Gupta, S. Gupta, N. Ghosh, and P.K. Gupta, Journal of Photochemistry and Photobiology B, 85, 109 – 117 (2006).
    21. Depth resolved fluorescence measurement in layered turbid medium by polarized fluorescence spectroscopy; N. Ghosh, S. K.  Majumder, H. S. Patel and P. K. Gupta, Optics Letters, 30, 162 - 164 (2005).
    22. Depolarization of light in a multiply scattering medium: effect of refractive index of scatterer; Nirmalya Ghosh, Asima Pradhan, Pradeep Kumar Gupta, Sharad Gupta, V. Jaiswal and R. P. Singh, Physical Review E, 70, 066607,1 -7 (2004).
    23. N2 laser excited autofluorescence spectroscopy of formalin-fixed human breast tissue; S.K. Majumder, N. Ghosh, P.K. Gupta, Journal of Photochemistry and Photobiology B, 81, 33 – 42 (2005).
    24. Relevance Vector Machine for Optical Diagnosis of Cancer; S.K. Majumder, N. Ghosh and P.K. Gupta, Lasers in Surgery and Medicine, 36, 323 – 333  (2005).
    25. Support Vector Machine for Optical Diagnosis of Cancer; S.K. Majumder, N. Ghosh and P.K. Gupta, Journal of Biomedical Optics, 10, 024034, 1-14 (2005).
    26. A fluorescence spectroscopic study of honey and cane sugar syrup; N. Ghosh, Y. Verma, S.K. Majumder and P.K. Gupta, Food Science and Technology Research, 11 (1) (2005).
    27. Fluorometric estimation of concentration of NADH from human blood sample; A. Uppal, N. Ghosh, A. Datta and P.K. Gupta, Biotechnology and Applied Biochemistry, 40, 1-5 (2004).
    28. Depolarization of light in tissue phantoms – effect of a distribution in the size of scatterers; N. Ghosh, H.S. Patel, P.K. Gupta, Optics Express, 11, 2198 –2205 (2003).
    29. Depolarization of light in tissue phantoms – effect of collection geometry; N. Ghosh, P.K. Gupta, H.S. Patel, B. Jain and B.N. Singh “Optics Communications, 222, 93 –99 (2003).
    30. Nonlinear Pattern Recognition for Laser-Induced Fluorescence Diagnosis of Cancer;  Shovan K Majumder, Nirmalya Ghosh, Sudhir Kataria, and Pradeep K Gupta, Lasers in Surgery and Medicine, 33, 48:56 (2003).
    31. Recovery of intrinsic fluorescence from the measured fluorescence in a turbid medium: an experimental approach; N.C. Biswal, S. Gupta, N. Ghosh, A. Pradhan, Optics Express, 11, 3320 –3321 (2003).
    32. Fluorescence depolarization in a scattering medium: Effect of size parameter of scatterer; N. Ghosh, S.K. Majumder and P.K. Gupta, Physical. Review E, 65, 26608, 1-6 (2002).
    33. Polarized fluorescence spectroscopy of human tissues; N. Ghosh, S.K.Majumder, and P.K.Gupta, Optics Letters, 27, 2007 - 2009 (2002).
    34. Diffuse reflectance studies of edible fats; N. Ghosh, A.Datta and P.K. Gupta,  Applied Spectroscopy, 56, 1094 – 1097 (2002).
    35. Spatial variation of fluorescence in human breast tissues; M.S. Nair, N. Ghosh, N.S. Raju and A. Pradhan,  Applied Optics, 41, 4024 – 4035 (2002).
    36. A pilot study on the use of autofluorescence spectroscopy for diagnosis of the cancer of human oral cavity; S.K. Majumder, S.K. Mohanty, N. Ghosh, P.K. Gupta, D.K. Jain and Fareed Khan, Current Science, 79, 1089 - 1094 (2000).
    37. Measurement of optical transport properties of malignant and normal human breast tissues; N. Ghosh, S.K. Mohanty, S.K. Majumder and P.K. Gupta, Applied Optics, 40, 176 - 184 (2001).
    38. Depolarization of Autofluorescence from Malignant and Normal Human Breast Tissues; S.K.Mohanty, N.Ghosh, S.K.Majumder, and P.K. Gupta, Applied Optics, 40, 1147 - 1154 (2001).

    Book Chapters

    1. Polarized light assessment of complex turbid media such as biological tissues using Mueller matrix decomposition; Chapter 9, Handbook of Photonics for Biomedical Science, Edited by Valery V. Tuchin, Taylor and Francis Publishing, pp 253 – 282, Nirmalya Ghosh, Michael Wood, and Alex Vitkin (2010).
    2. Towards noninvasive glucose sensing using polarization analysis of multiply scattered light; Chapter -17,  Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues, Edited by Valery V. Tuchin,  Series in Medical Physics and Biomedical Engineering  Volume: 12, Taylor and Francis Publishing, Michael F. G. Wood, Nirmalya Ghosh, Xinxin Guo and I. Alex Vitkin (2008).
    3. Lasers and laser tissue interaction; Fundamentals & Applications of Biophotonics in Dentistry, Ed. A Kishen and A Asundi, Imperial College Press, London, pp. 123-148 P. K. Gupta, N. Ghosh, and H. S. Patel (2007).
    4. 

    Media Reports

    1. Diagnostic photomedicine: probing biological tissues with polarized light; SPIE Newsroom article, 10.1117/2.1200808.1238, (2008).
    2. Mueller Matrix Approach for Discriminating Optical Rotation;  Optics and Photonics News, 41, (2006).
    3. Shedding light on cancer detection;  News India, page 13, (February (2001).
    4. Indian group develops tools for oral cancer diagnosis; The Lancet Oncology, 2, 258, (May 2001).