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Jayasri Das Sarma

Jadavpur University, Kolkata (1995)
Area of Interest:
Neural Cell Biology, Neuro Science
Email ID:
Research Interest:

Neural Cell Biology, Neurovirology, and Neurobiology of Diseases.

Academic Qualification:
  • M. Sc., Calcutta University, Kolkata, 1990
  • M. Phil., Calcutta University, Kolkata, India; Environmental Science, 1991
  • Ph.D., Jadavpur University, Kolkata, India; Immunology/Chemistry, 1995
  • Research Associate, Rockefeller Foundation Program, MRDG, Indian Institute of Science, Bangalore, India. (1996 - 97).
  • Post Doctoral Fellow, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA. (1997-99).
  • Post Doctoral Researcher, Institute for Environmental Sciences and Department of Physiology, University of Pennsylvania, USA. (1999-2001).
  • Research Associate, Institute for Environmental Medicine and Department of Physiology, University of Pennsylvania, Philadelphia, USA. (2001-03).
  • Senior Research Investigator, Department of Microbiology and Physiology, University of Pennsylvania, Philadelphia, USA. (2003 – Sept, 04).
  • Assistant Professor, Department of Neurology, Thomas Jefferson University, Philadelphia, USA. (Oct, 2004 – Sept, 2008).
  • Adjunct Faculty, Department of Neurology, Thomas Jefferson University, Philadelphia, USA. (Oct, 2008 – till date).
  • Visiting Scientist, Children Hospital of Philadelphia (CHOP), Philadelphia, USA. (Oct, 2008 – till date).
  • Associate Professor, Indian Institute of Science Education and Research (IISER), Kolkata, India. (Oct, 2008 – ).
Awards and Honors:
  • Graduate Aptitude Test for Engineering Fellowship – Ministry of Human, Govt. of India, India, 1990.
  • Junior Research Fellowship, Indian Statistical Institute, India, 1991.
  • Lectureship - Council of Scientific and Industrial Research and University Grants Commission, Govt. of India, 1992.
  • Senior Research Fellowship (SRF), Indian Statistical Institute, India, 1993.
  • Advanced Postdoctoral Fellowship Award: National Multiple Sclerosis Society, USA, 2001.
  • Science Horizon Research Internships-Mentor Award; Bryn Mawr College, USA, 2007.
  • Lindback Distinguished Teaching Award / Junior Faculty Career Enhancement Award, USA, 2007.
List of Publications:

[Authors’ Last name, initial of the Name, Year of Publication “Title of the paper”, Journal details]*Corresponding Author

  1. Vijaykameswara Rao, N.;  Shivshankar, M.; Abhinoy, K.; Das Sarma, J.*; Shunmugam, R.* 2011 "Norbornene Derived Doxorubicin Copolymers as Drug Carriers with pH Responsive Hydrazone Linker" Biomacromolecules, http://pubs.acs.org/doi/abs/10.1021/bm201478k.
  2. Shindler, K. S., D. Chatterjee, K. Biswas, A. Goyal, M. Dutt, M. Nassrallah, R. S. Khan, and Das Sarma, J*. 2011. Macrophage-mediated optic neuritis induced by retrograde axonal transport of spike gene recombinant mouse hepatitis virus. J Neuropathol Exp Neurol 2011 70:470-480.
  3. Das Sarma, J*. A mechanism of virus-induced demyelination. Interdiscip Perspect Infect Dis 2010:109239.( Invited Review)
  4. Das Sarma J*. γδ T cells and IL-17/IL-17R signaling axis in CNS inflammation.  International Journal of Interferon, Cytokine and Mediator Research. 2010:2 149–155.(Invited review)
  5. Das Sarma, J*, L. C. Kenyon, S. T. Hingley, and K. S. Shindler. 2009. Mechanisms of primary axonal damage in a viral model of multiple sclerosis. J Neurosci 29:10272-10280.
  6. Das Sarma, J., B. Ciric, R. Marek, S. Sadhukhan, M. L. Caruso, J. Shafagh, D. C. Fitzgerald, K. S. Shindler, and A. Rostami. 2009. Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis. J Neuroinflammation 6:14.
  7. Das S, Smith TD, Das Sarma J., Ritzenthaler JD, Maza J, Kaplan BE, Cunningham LA, Suaud L, Hubbard MJ, Rubenstein RC, Koval M. 2009. ERp29 restricts Connexin43 oligomerization in the endoplasmic reticulum. Mol Biol Cell. 20(10): 2593.
  8. Das Sarma, J*., K. Iacono, L. Gard, R. Marek, L. C. Kenyon, M. Koval, and S. R. Weiss. 2008. Demyelinating and nondemyelinating strains of mouse hepatitis virus differ in their neural cell tropism. J Virol 82:5519-5526.
  9. Shindler, K. S., L. C. Kenyon, M. Dutt, S. T. Hingley, and Das Sarma, J*. 2008. Experimental optic neuritis induced by a demyelinating strain of mouse hepatitis virus. J Virol 82:8882-8886.
  10. Marek, R, Caruso, M, Rostami, AM, Grinspan, JB, Das Sarma J*. Simultaneous isolation of highly purified astrocytes and microglia. MACS & More; Special Edition: neuroscience meets MACS® Technology. Vol 12-2; 7-9. 2010. (Cover Page illustration).
  11. Das Sarma, J., B. E. Kaplan, D. Willemsen, and M. Koval. 2008. Identification of rab20 as a potential regulator of connexin 43 trafficking. Cell Commun Adhes 15:65-74.
  12. Fitzgerald, D. C., B. Ciric, T. Touil, H. Harle, J. Grammatikopolou, Das Sarma,J., Gran,B., G. X. Zhang, and A. Rostami. 2007. Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J Immunol 179:3268-3275.
  13. Qiu, Z., S. T. Hingley, G. Simmons, C. Yu, Das Sarma,J.,  P. Bates, and S. R. Weiss. 2006. Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry. J Virol 80:5768-5776..
  14. Maza, J., Das Sarma,J., and Koval, M. 2005. Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum. J Biol Chem 280:21115-21121.
  15. Constantinescu, C. S., M. Tani, R. M. Ransohoff, M. Wysocka, B. Hilliard, T. Fujioka, S. Murphy, P. J. Tighe, Das Sarma, J, G. Trinchieri, and A. Rostami. 2005. Astrocytes as antigen-presenting cells: expression of IL-12/IL-23. J Neurochem 95:331-340.
  16. Das Sarma, J., S. Das, and M. Koval. 2005. Regulation of connexin43 oligomerization is saturable. Cell Commun Adhes 12:237-247.
  17. Fu, L., D. M. Gonzales, Das  Sarma, J., and E. Lavi. 2004. A combination of mutations in the S1 part of the spike glycoprotein gene of coronavirus MHV-A59 abolishes demyelination. J Neurovirol 10:41-51.
  18. Gonzales, D. M., L. Fu, Y. Li, Das Sarma,J.,  and E. Lavi. 2004. Coronavirus-induced demyelination occurs in the absence of CD28 costimulatory signals. J Neuroimmunol 146:140-143.
  19. Maza, J., Mateescu,M., Das Sarma,J., and M. Koval. 2003. Differential oligomerization of endoplasmic reticulum-retained connexin43/connexin32 chimeras. Cell Commun Adhes 10:319-322.
  20. Das Sarma, J., F. Wang, and M. Koval. 2002. Targeted gap junction protein constructs reveal connexin-specific differences in oligomerization. J Biol Chem 277:20911-20918.
  21. Das Sarma, J., E. Scheen, S. H. Seo, M. Koval, and S. R. Weiss. 2002. Enhanced green fluorescent protein expression may be used to monitor murine coronavirus spread in vitro and in the mouse central nervous system. J Neurovirol 8:381-391.
  22. Das Sarma, J., R. A. Meyer, F. Wang, V. Abraham, C. W. Lo, and M. Koval. 2001. Multimeric connexin interactions prior to the trans-Golgi network. J Cell Sci 114:4013-4024.
  23. Navas, S., S. H. Seo, M. M. Chua, Das Sarma,J., E. Lavi, S. T. Hingley, and S. R. Weiss. 2001. Murine coronavirus spike protein determines the ability of the virus to replicate in the liver and cause hepatitis. J Virol 75:2452-2457.
  24. Das Sarma, J., L. Fu, S. T. Hingley, M. M. Lai, and E. Lavi. 2001. Sequence analysis of the S gene of recombinant MHV-2/A59 coronaviruses reveals three candidate mutations associated with demyelination and hepatitis. J Neurovirol 7:432-436.
  25. Das Sarma, J., L. Fu, S. T. Hingley, and E. Lavi. 2001. Mouse hepatitis virus type-2 infection in mice: an experimental model system of acute meningitis and hepatitis. Exp Mol Pathol 71:1-12.
  26. Das Sarma, J., C. W. Lo, and M. Koval. 2001. Cx43/beta-gal inhibits Cx43 transport in the Golgi apparatus. Cell Commun Adhes 8:249-252.
  27. Das Sarma, J., L. Fu, J. C. Tsai, S. R. Weiss, and E. Lavi. 2000. Demyelination determinants map to the spike glycoprotein gene of coronavirus mouse hepatitis virus. J Virol 74:9206-9213.
  28. Lavi, E., Das Sarma, J., and S. R. Weiss. 1999. Cellular reservoirs for coronavirus infection of the brain in beta2-microglobulin knockout mice. Pathobiology 67:75-83.
  29. Das Sarma, J., C. Duttagupta, E. Ali, and T. K. Dhar. 1995. Improved microbiological assay for folic acid based on microtiter plating with Streptococcus faecalis. J AOAC Int 78:1173-1177.
  30. Das Sarma, J., C. Duttagupta, E. Ali, and T. K. Dhar. 1995. Direct microtitre plate enzyme immunoassay of folic acid without heat denaturation of serum. J Immunol Methods 184:7-14.
  31. Das Sarma, J., C. Duttagupta, E. Ali, and T. K. Dhar. 1995. Antibody to folic acid: increased specificity and sensitivity in ELISA by using epsilon-aminocaproic acid modified BSA as the carrier protein. J Immunol Methods 184:1-6.