- Reaction Mechanisms: General methods (both kinetic and non-kinetic) of study of mechanism of organic reactions: isotopic method, cross-over experiments, (intermediate trapping overview, discuss case to case later), basic stereochemistry R-, S-, E-, Z- classification; energy of activation; thermodynamic control and kinetic control of reactions..
- Reactive Intermediates: Generation, geometry, stability and reactions of carbonium ions and carbanions, free radicals, carbenes, benzynes and nitrenes.
- Substitution Reactions: (Recap: Substitution mechanisms); electrophilic and nucleophilic reactions of aromatic compounds including heterocyclic compoundspyrrole, furan, thiophene and indole.
- Elimination Reactions: E1, E2 and E1cb mechanisms; orientation in E2 reactions Saytzeff and Hoffmann; pyrolytic syn elimination Chugaev and Cope eliminations.
- Addition Reactions: Electrophilic addition to C=C and C=C; nucleophilic addition to C=O, C=N, conjugated olefins and carbonyls.
- Reactions and Rearrangements: Aldol condensation, Claisen condensation, Dieckmann, Perkin, Knoevenagel, Witting, Clemmensen, Wolff-Kishner, Cannizzaro; Stobbe, benzoin and acyloin condensations; Fischer indole synthesis, Skraup synthesis, Bischler-Napieralski, Sandmeyer, Reimer-Tiemann and Reformatsky reactions; Pinacol-pinacolone, Hoffmann, Beckmann, BaeyerVilliger, Favorskii, Fries, Claisen, Cope, Stevens and Wagner- Meerwein rearrangements.
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