Details of CH2202 (Spring 2015)

Level: 4 Type: Theory Credits: 3.0

Course CodeCourse NameInstructor(s)
CH2202 Reaction Mechanisms in Organic Chemistry Subhajit Bandyopadhyay

Syllabus
Reaction Mechanisms: General methods (kinetic and non-kinetic) for studying reaction mechanism: isotopic method, cross-over experiments, basic stereochemistry R-, S-, E-, Z- classification; energy of activation; thermodynamic control and kinetic control of reactions. Reactive Intermediates: Generation, geometry, stability and reactions of carbonium ions and carbanions, free radicals, carbenes, benzynes and nitrenes. Substitution Reactions: electrophilic and nucleophilic reactions of aliphatic and aromatic compounds including heterocyclic compoundspyrrole, furan, thiophene and indole. Elimination Reactions: E1, E2 and E1cb mechanisms; orientation in E2 reactions Saytzeff and Hoffmann; pyrolytic syn elimination Chugaev and Cope eliminations. Addition Reactions: Electrophilic addition to C=C and aromatic systems; nucleophilic addition to C=O, C=N, conjugated olefins and carbonyls; conjugate addition reactions; ylides: sulphur and phosphorous ylides; Polarity reversal - Umpolung. Reactions and Rearrangements: Extension of the concept to write mechanisms for reactions and rearrangements such as aldol condensation, Claisen condensation, Wolff-Kishner, Cannizzaro; benzoin and acyloin condensations; Reimer-Tiemann and Reformatsky reactions; Pinacol-pinacolone, Hoffmann, Beckmann, BaeyerVilliger, Favorskii, Fries, Claisen, Cope, and Wagner- Meerwein rearrangements.

References
(1) Guidebook to Mechanism in Organic Chemistry (6th Edition) by Peter Sykes; (2) March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 5th Edition by Jerry March; (3) Organic Chemistry by Jonathan Clayden, Nick Greeves, Stuart Warren and Peter Wothers.

Course Credit Options

Sl. No.ProgrammeSemester NoCourse Choice
1 IP 2 Not Allowed
2 IP 4 Not Allowed
3 MR 2 Not Allowed
4 MR 4 Not Allowed
5 MS 4 Core
6 RS 1 Not Allowed
7 RS 2 Not Allowed