Details of CH4201 (Spring 2015)

Level: 8 Type: Theory Credits: 3.0

Course CodeCourse NameInstructor(s)
CH4201 Bioinorganic Chemistry Arindam Mukherjee,
R. N. Mukherjee

Syllabus
Electron Transfer: Iron-Sulphur Proteins, Blue Copper Proteins. Dioxygen Binding: Nature of the Dioxygen-Metal Bond, Contributions to Reversible Dioxygen Binding; Superoxide and Peroxide Dismutases. Oxidases and Oxygenases: Mononuclear Non-Heme Enzymes, Binuclear Copper Enzymes, Trinuclear Copper Cluster Enzymes, The CuB-Heme Site in Cytochrome c Oxidase, intermediates: Substrate Activation, Dioxygen Activation. Bioinorganic Chemistry of Iron: (a) Substrate Activation, Catechol Dioxygenases, Bio-Inspired Oxidation Catalysis; (b) Reaction Intermediates: Iron-Peroxo Intermediates, High-Valent Iron-Oxo Intermediates, The Road to Non-Heme Oxoferryls; (c) Oxygen and C-H Activation Chemistry of Methane Monooxygenase (MMO), the conversion of Methane to Methanol in Methanotrophic Bacteria, Mechanistic Studies on the Hydroxylation of Methane by Methane Monooxygenase; (d) Non-Heme Iron Analogues of Cytochrome P450. Synthetic Models for Non-Heme Carboxylate-Bridged Diiron Metalloproteins: Strategies and Tactics, Hydrogenases and Nitrogenases: [Fe]-Hydrogenases. [NiFe]-Hydrogenases, Manganese Chemistry with the Relevance to Photosystem II (PS-II); Bioinspired Catalyses towards renewable alternative carbon-free energy. Metal ion transport and storage - Ferritin - structure, mechanisms of iron entry, mineralization and exit, difference from common metalloenzymes. Metal toxicity: iron overload. Urease: Conversion of urea to ammonia, structure of urease, reaction mechanism; Metals in medicine: Introduction to structure of DNA and proteins double helical structure, supercoiled forms, interaction among bases, helical twist, alpha helices, beta sheets, loops, disulfide bonds, torsion/dihedral angle of peptide bonds, primary to quaternary structure of proteins. Intercalation in DNA, binding to guanine bases, alkylation of nitrogen in the bases, cisplatin- syntheses and mechanism of action, mustards in clinic and mechanism of action of mustards, anthracyclines in clinic and their mechanism of action, topoisomerase inhibition, protein kinase inhibition, combination therapy. Fundamentals of Biological macromolecules: Proteins, Nitrogenases and nitrogen fixation role of molybdenum, Nitrogen cycle, cofactors in nitrogenases, Cobalt in biology, Structure and function of vitamin B12 the first organometallic compound in biology, Coenzymes, mutase activity, methyl transfer reactions Molybdenum-cofactor enzymes -xanthine oxidase.

References
(1) Bioinorganic Chemistry by Eiichiro Ochiai, Elsevier, London, (2008); (2) Inorganic Chemistry by D. F. Shriver and P. W. Atkins, Oxford University Press, Oxford, (1999); (3) Physical Methods in Bioinorganic Chemistry by L. Que. Jr., University Science Books, (2000); (4) Bioinorganic Chemistry by Asim K. Das, Books and Allied Pvt. Ltd., Kolkata, (2007).

Course Credit Options

Sl. No.ProgrammeSemester NoCourse Choice
1 IP 2 Not Allowed
2 IP 4 Core
3 MR 2 Not Allowed
4 MR 4 Not Allowed
5 MS 8 Core
6 RS 1 Elective
7 RS 2 Elective