Details of LS3202 (Spring 2017)
Level: 3 | Type: Theory | Credits: 3.0 |
Course Code | Course Name | Instructor(s) |
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LS3202 | Gene Regulation and Cellular Communication | Amirul Islam Mallick, Partho Sarothi Ray |
Syllabus |
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1. Basic concepts in regulation of gene expression: requirement for regulation, advantages of regulation (robustness, fine-tunedness etc.), features of regulatory systems, natural selection of regulatory systems, spatial and temporal regulation, signal processing and information transduction, signal transduction pathways.
2. Physical chemistry of regulation: equilibria of biological reactions, effects on molecular affinity and concentrations. 3. Systems biology of gene regulation: Regulatory networks, network motifs, negative feedback as a conserved regulatory system, advantages of autoregulation: calculation of response time and robustness, feed forward loops. 4. Mechanisms of gene expression: DNA replication and repair, prokaryotic and eukaryotic transcription, post-transcriptional processes (splicing, mRNA export, localization, translation, decay), post-translational modifications as means of regulation of gene function. 5. Structure and function of gene regulatory proteins. 6. Concepts in cellular communication: response to stimuli as determinant of gene regulation, ligand-receptor interactions, calculation of dissociation constants and Scatchard analysis, nature and variety of signal transduction pathways. 7. Regulatory systems: Phage strategies. 8. Regulatory systems: Prokaryotic transcription regulation, operon concept, regulation of transcription termination, attenuation. 9. Regulatory systems: Eukaryotic transcription regulation, epigenetic regulation of transcription through reversible chromatin modification, transcription factors. 10. Regulatory systems: Post-transcriptional regulation in prokaryotes and eukaryotes, regulation mediated by cis-acting and trans-acting RNAs, riboswitches, regulation mediated by mRNA transport, splicing and localization, translation regulation: global and transcript specific, protein-mediated translation regulation, miRNA-mediated translation regulation. 11. Seminars covering examples of various regulatory systems. |
References |
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Course Credit Options
Sl. No. | Programme | Semester No | Course Choice |
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1 | IP | 2 | Core |
2 | IP | 4 | Elective |
3 | IP | 6 | Not Allowed |
4 | MR | 2 | Not Allowed |
5 | MR | 4 | Not Allowed |
6 | MS | 6 | Core |
7 | RS | 1 | Elective |
8 | RS | 2 | Elective |