About US

The Subhajit
Bandyopadhyay Group
Light Triggered Chemistry Research Laboratory
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We work on the synthesis of molecules, study the kinetics. photochemical, and photophysical properties of the synthesized molecules to understand their behavior. Our molecules toggle between two structures using light and we utilize the structural changes to control several properties such as aggregation-disaggregation, supramolecular assembly - disassembly, differential binding properties, and so on.



◘ All photonic Molecular logic gates.
◘ Formation and dissociation of supramolecular assembly.
◘ Light activated binding to biomolecules.
◘ Light activated metal/anion binding.

For representative examples, see:

Photomodulation of fluoride ion binding through anion-π interactions using a photoswitchable azobenzene system.
Scientific Reports 6, Article number: 22928 (2016), DOI:10.1038/srep22928

Light-triggered assembly–disassembly of an ordered donor–acceptor π-stack using a photoresponsive dimethyldihydropyrene π-switch.
Organic & Biomolecular Chemistry, 2016,14, 5744-5750, DOI: 10.1039/C6OB00101G

Photoreversible Assembly–Disassembly of a Polymeric Structure by Using an Azobenzene Photoswitch and Al3+ Ions.
Chemistry: European Journal, 2014, DOI: 10.1002/chem.201402321

Light gated reversible modulation of Cu2+ binding.
RSC Advances, 2013,3, 3739-3744, DOI:10.1039/C3RA23089A



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The government and various non-government organizations are vigilant about environment pollution by various chemical entities, both natural as well as man-made. Although there are many regulatory bodies to monitor the environmentally relevant chemical species, there is a need to develop fast, sensitive and selective methods to monitor them.

Our featured work on sensors:

Altered selectivity of a dipicolylamine based metal ion receptor.
Chemical Communications, 2014, 50, 64-66, DOI: 10.1039/C3CC46285D



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A small change for a sensor - a big leap for its selectivity.

A highly selective chemodosimeter for fast detection and intracellular imaging of Hg2+ ions based on a dithiocarbamate–isothiocyanate conversion in aqueous ethanol.
Organic & Biomolecular Chemistry, 2014, 12, 1072-1078, DOI: 10.1039/C3OB42108B



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Featured as inside cover of the journal.


A single molecule multi analyte chemosensor differentiates among Zn2+, Pb2+ and Hg2+: modulation of selectivity by tuning of solvents.
RSC Adv., 2012,2, 7033-7036, DOI: 10.1039/C2RA20822A



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Killing three birds with one shot. A multi-ion sensor.
We are also involved in designing of efficient organo-catalysts taking lessons from the Nature and study their activities and mechanisms.

Recent work from our group demonstrates the use of a photoswitchable dicarboxylic acid as a glycosidase mimic. The activity can be turned 'off' and 'on' using visible and UV light respectively.

A photoresponsive glycosidase mimic.
Chemical Communications, 2014, 50, 10577-10579 DOI: 10.1039/C4CC03394A



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With a rise in the development of mobile learning environments, smartphone based apps have become an appealing method of teaching in the classroom and labs. Our goal is use the features of smartphones like camera to study enzyme kinetics and develop low-cost spectrophotometry undergrad experiments. We aim to turn the smartphone into a portable colorimeter and a spectrometer.

Titration ColorCam: The Sound and Feel of Titration Endpoints.
We have developed a smartphone aid for the colourblind and visually impaired students for performing titration experiments. Available freely on Google Play Store. View the application demonstration here.

The Sound and Feel of Titrations: A Smartphone Aid for Color-Blind and Visually Impaired Students.
Journal of Chemical Education, 2017, Article ASAP, DOI: 10.1021/acs.jchemed.7b00027




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Our Publications

Check out some of our latest and amazing projects.



A Highly Selective Sub-ppm Naked-Eye Detection of Hydrazine with Conjugated-1,3-Diketo Probes: Imaging Hydrazine in Drosophila Larvae .
Biswajit Roy, Sudipta Halder, Abhishek Guha, and Subhajit Bandyopadhyay*.

Analytical Chemistry.
2017, XX (X), pp XX
DOI: 10.1021/acs.analchem.7b03503




The Sound and Feel of Titrations: A Smartphone Aid for Color-Blind and Visually Impaired Students.
Subhajit Bandyopadhyay* and
Balraj B. Rathod.

Journal of Chemical Education.
2017, 94 (7), pp 946–949
DOI: 10.1021/acs.jchemed.7b00027




Photomodulation of fluoride ion binding through anion-π interactions using a photoswitchable azobenzene system.
Anushri Rananaware, Mousumi Samanta, Rajesh S. Bhosale, Mohammad Al Kobaisi, Biswajit Roy, Varun Bheemireddy, Sidhanath V. Bhosale, Subhajit Bandyopadhyay,* Sheshanath V. Bhosale*.

Scientific Reports 6,
Article number: 22928 (2016) DOI:10.1038/srep22928




A Kamikaze Approach for Capturing Hg2+ Ions through the Formation of a One-Dimensional Metal–Organometallic Polymer.
Sk. Atiur Rahaman, Biswajit Roy, Soumik Mandal, Subhajit Bandyopadhyay.

Inorganic Chemistry, 2016, 55 (3),
1069–1075
DOI: 10.1021/acs.inorgchem.5b02104



Light-triggered assembly–disassembly of an ordered donor–acceptor π-stack using a photoresponsive dimethyldihydropyrene π-switch.
V. Siva Rama Krishna, Mousumi Samanta, Suman Pal, N. P. Anurag, and Subhajit Bandyopadhyay.

Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00101G




Photoreversible Assembly–Disassembly of a Polymeric Structure by Using an Azobenzene Photoswitch and Al3+ Ions.
Joydev Hatai and Subhajit Bandyopadhyay.

Chemistry - A European Journal 2014,
20, 10020–10026.





A highly efficient tandem [3+2] “click” cycloaddition /6-exo-cyclization strategy for the construction of triazole fused pyrazines.
Biswajit Roy, Debashis Mondal, Joydev Hatai, and Subhajit Bandyopadhyay.

RSC Advances, 2014, 4, 56952-56956.
DOI: 10.1039/C4RA12489H




Determination and Comparison of Carbonyl Stretching Frequency of a Ketone in Its Ground State and the First Electronic Excited State.
Subhajit Bandyopadhyay and Saswata Roy.

Journal of Chemical Education, 2014, 91 (11), 1995–1998
DOI: 10.1021/ed500442a




A photoresponsive glycosidase mimic.
Mousumi Samanta , V. Siva Rama Krishna, and Subhajit Bandyopadhyay.

Chem. Commun., 2014, 50, 10577-10579
DOI: 10.1039/C4CC03394A




A highly selective chemodosimeter for fast detection and intracellular imaging of Hg2+ ions based on a dithiocarbamate–isothiocyanate conversion in aqueous ethanol.
Suman Pal, Joydev Hatai, Mousumi Samanta, Alok Shaurya, and Subhajit Bandyopadhyay.

Org. Biomol. Chem., 2014, 12, 1072-1078
DOI: 10.1039/C3OB42108B




Altered selectivity of a dipicolylamine based metal ion receptor.
Joydev Hatai and Subhajit Bandyopadhyay.

Chem. Commun., 2014, 50, 64-66
DOI: 10.1039/C3CC46285D, Communication



The importance of water exclusion: an effective design strategy for detection of Al3+ ions with high sensitivity.
Joydev Hatai, Mousumi Samanta, V. Siva Rama Krishna, Suman Pal, and Subhajit Bandyopadhyay.

RSC Adv., 2013, 3, 22572-22579
DOI: 10.1039/C3RA42043D, Paper



Light gated reversible modulation of Cu2+ binding.
Suman Pal, Joydev Hatai, K. Srikanth, and Subhajit Bandyopadhyay.

RSC Adv., 2013, 3, 3739-3744
DOI: 10.1039/C3RA23089A, Paper



Fluorescent detection of silver ions in water with organic nano-aggregates.
Joydev Hatai, Suman Pal, and Subhajit Bandyopadhyay.

RSC Adv., 2012, 2, 10941-10947
DOI: 10.1039/C2RA21717A, Paper


peri-Dimethylamino substituent effects on proton transfer at carbon in α-naphthylacetate esters: a model for mandelate racemase.
Richard J. Delley, Subhajit Bandyopadhyay, Mark A. Fox, Constanze Schliehe, David R. W. Hodgson, Florian Hollfelder, Anthony J. Kirby, and AnnMarie C. O'Donoghue.

Org. Biomol. Chem., 2012, 10, 590-596
DOI: 10.1039/C1OB06525D, Paper


A single molecule multi analyte chemosensor differentiates among Zn2+, Pb2+ and Hg2+: modulation of selectivity by tuning of solvents.
Joydev Hatai, Suman Pal, Gregor P. Jose, Tapas Sengupta, and Subhajit Bandyopadhyay.

RSC Adv., 2012, 2, 7033-7036
DOI: 10.1039/C2RA20822A, Communication



Efficient Catalytic Promiscuity for Chemically Distinct Reactions.
Babtie, Ann C.; Bandyopadhyay, Subhajit; Olguin, Luis F.; Hollfelder, Florian.

Angewandte Chemie, International Edition (2009), 48(20), 3692-3694, S3692/1-S3692/6.
DOI:10.1002/anie.200805843


A Molecule-Based 1:2 Digital Demultiplexer.
Andreasson, Joakim; Straight, Stephen D.; Bandyopadhyay, Subhajit; Mitchell, Reginald H.; Moore, Thomas A.; Moore, Ana L.; Gust, Devens.

Journal of Physical Chemistry C (2007), 111(38), 14274-14278.
DOI:10.1021/jp074429p3


Isotactic Polyethylenimines Induce Formation of L-Amino Acids in Transamination.
Bandyopadhyay, Subhajit; Zhou, Wenjun; Breslow, Ronald.

Organic Letters (2007), 9(6), 1009-1012. Language: English, Database: CAPLUS,
DOI:10.1021/ol0630604


Molecular 2:1 digital multiplexer.
Andreasson, Joakim; Straight, Stephen D.; Bandyopadhyay, Subhajit; Mitchell, Reginald H.; Moore, Thomas A.; Moore, Ana L.; Gust, Devens.

Angewandte Chemie, International Edition (2007), 46(6), 958-961.
DOI:10.1002/anie.200603856


Reversible Photo-regulation of a Hammerhead Ribozyme Using a Diffusible Effector.
Lee, Hyun-Wu; Robinson, Stephen G.; Bandyopadhyay, Subhajit; Mitchell, Reginald H.; Sen, Dipankar.

Journal of Molecular Biology (2007), 371(5), 1163-1173.
DOI:10.1016/j.jmb.2007.06.042


Multistate π Switches: Synthesis and Photochemistry of a Molecule Containing Three Switchable Annelated Dihydropyrene Units.
Mitchell, Reginald H.; Bohne, Cornelia; Wang, Yunxia; Bandyopadhyay, Subhajit; Wozniak, Chelsea B.

Journal of Organic Chemistry (2006), 71(1), 327-336.
DOI:10.1021/jo052153g


Water exclusion and enantioselectivity in catalysis.
Breslow, Ronald; Bandyopadhyay, Subhajit; Levine, Mindy; Zhou, Wenjun.

ChemBioChem (2006), 7(10), 1491-1496.
DOI:10.1002/cbic.200600120


13-Methyl-2,6-dithia[7]metacyclophane: A Useful Molecule To Connect VT NMR Results and Structure with Calculations.
Mitchell, Reginald H.; Blunden, Rachel; Hollett, Gavin; Bandyopadhyay, Subhajit; Williams, Richard Vaughan; Twamley, Brendan.

Journal of Organic Chemistry (2005), 70(2), 675-680.
DOI:10.1021/jo0484272


Molecular AND and INHIBIT Gates Based on Control of Porphyrin Fluorescence by Photochromes.
Straight, Stephen D.; Andreasson, Joakim; Kodis, Gerdenis; Bandyopadhyay, Subhajit; Mitchell, Reginald H.; Moore, Thomas A.; Moore, Ana L.; Gust, Devens.

Journal of the American Chemical Society (2005), 127(26), 9403-9409.
DOI:10.1021/ja051218u


Linked Photoswitches Where Both Photochromes Open and Close.
Mitchell, Reginald H.; Bandyopadhyay, Subhajit.

Organic Letters (2004), 6(11), 1729-1732.
DOI:10.1021/ol049590m


Molecule-Based Photonically Switched Half-Adder.
Andreasson, Joakim; Kodis, Gerdenis; Terazono, Yuichi; Liddell, Paul A.; Bandyopadhyay, Subhajit; Mitchell, Reginald H.; Moore, Thomas A.; Moore, Ana L.; Gust, Devens.

Journal of the American Chemical Society (2004), 126(49), 15926-15927.
DOI:10.1021/ja045577l


Photonic Switching of Photoinduced Electron Transfer in a Dihydropyrene-Porphyrin-Fullerene Molecular Triad.
Liddell, Paul A.; Kodis, Gerdenis; Andreasson, Joakim; De la Garza, Linda; Bandyopadhyay, Subhajit; Mitchell, Reginald H.; Moore, Thomas A.; Moore, Ana L.; Gust, Devens.

Journal of the American Chemical Society (2004), 126(15), 4803-4811.
DOI:10.1021/ja039800a


Mechanistic studies on the photochromism of [e]-annelated dimethyldihydropyrenes.
Sheepwash, Molina A. L.; Ward, Timothy R.; Wang, Yunxia; Bandyopadhyay, Subhajit; Mitchell, Reginald H.; Bohne, Cornelia.

Photochemical & Photobiological Sciences (2003), 2(2), 104-112.
DOI:10.1039/b208952a


A Theoretical and Experimental Scale of Aromaticity. The First Nucleus-Independent Chemical Shifts (NICS) Study of the Dimethyldihydropyrene Nucleus.
Williams, Richard Vaughan; Armantrout, John R.; Twamley, Brendan; Mitchell, Reginald H.; Ward, Timothy R.; Bandyopadhyay, Subhajit.

Journal of the American Chemical Society (2002), 124(45), 13495-13505.
DOI:10.1021/ja020595t


Dimethyldihydropyrene-Dehydrobenzoannulene Hybrids: Studies in Aromaticity and Photoisomerization.
Kimball, David B.; Haley, Michael M.; Mitchell, Reginald H.; Ward, Timothy R.; Bandyopadhyay, Subhajit; Williams, Richard Vaughan; Armantrout, John R.

Journal of Organic Chemistry (2002), 67(25), 8798-8811.
DOI:10.1021/jo020462q

Teaching

Chemical Perspectives of Biological Pathways

How does nature make, transform, and manipulate biological molecules? This lecture course focuses on the fundamentals of chemical reactions in biological systems and more importantly, the chemical logic behind them.

Reaction Mechanisms in Organic Chemistry

This teaching course traces a reaction mechanism as a step by step sequence of elementary reactions by which overall chemical change occurs.

Physical Methods of Structural Elucidation

This lecture course features concepts that explain the process of determining the chemical structure of a compound. The characterization techniques taught include Nuclear Magnetic Resonance (NMR), mass spectrometry, and X-ray crystallography among others.

Publication related to teaching labs

Many moons ago, when I was teaching the spectroscopy lab, a cool and easy experiment to obtain the C=O stretch in the electronic excited state was designed. It did not require any expensive instruments and expertise. It requires skills in basic arithmetic though!



Determination and Comparison of Carbonyl Stretching Frequency of a Ketone in Its Ground State and the First Electronic Excited State.

Subhajit Bandyopadhyay and Saswata Roy
J. Chem. Educ., 2014, 91 (11), 1995–1998 DOI: 10.1021/ed500442a

Do you know that about 8% of the male population and 0.5% of the female population worldwide are color blind? Keeping that in mind, we have developed an Android based app "Titration ColorCam" and provided details of it in the paper in the Journal of Chemical Education.



The Sound and Feel of Titrations: A Smartphone Aid for Color-Blind and Visually Impaired Students

Subhajit Bandyopadhyay and Balraj B Rathod
J. Chem. Educ., 2017, 94 (7), pp 946–949
DOI: 10.1021/acs.jchemed.7b00027

Our Team

Jack Smith

Biswajit Roy

Senior Research Fellow

Jack Smith

Sanjib Ghosh

Senior Research Fellow

Jack Smith

Atiur Rahaman SK

Senior Research Fellow

Jack Smith

Monochura Saha

Junior Research Fellow

Jack Smith

Munshi Sahid Hossain

Junior Research Fellow

Alumni

Former Ph.D Students


1. Dr. Joydev Hatai. Currently PostDoc at Weizmann Institute-Israel.

2. Dr. Suman Pal. Currently PostDoc at National Chemical Laboratory Pune, India.

3. Dr. Mousumi Samanta. Currently PostDoc at Ben-Gurion University, Israel.

4. Dr. V. Siva Rama Krishna. Currently Faculty Member at
National Institute of Technology Warangal, India.

Former MS Project Students


1. Arghya Modak. Currently at Oxford University, UK.

2. Alok Shaurya. Currently at University of Victoria, British Columbia-Canada.

3. Saswata Roy. Currently at University of California, Irvine.

4. Anurag NP. Currently at University of Texas, Arlington.

5. Ankita Biswas. Currently at University of California, Irvine.

6. Balraj Rathod.

Former Summer Project Students


1. Arghya Banerjee.

2. Jagriti Banerjee, IISER Bhopal.

3. Raghupathy Raju. Scientist at Infrag.

4. Atiur Rahaman. Joined our group as a Ph.D. student.

Outreach

We are always keen to go to schools, colleges, to deliver talks and take part in discussions for the promotion of chemical education, history of science and prospects of science education.




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With the students and Prof. Hassan at INSA workshop 2014, Malda



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Subhajit Bandyopadhay

Subhajit Bandyopadhyay did his MSc from Indian Institute of Technology (IIT) Kanpur. He did his doctoral research under the supervision of Professor Reginald Mitchell at University of Victoria, British Columbia. This was followed by a postdoctoral position with Professor Ron Breslow at Columbia University in the city of New York. Following the footsteps of all his gurus, he believed that his education would be incomplete without a Cambridge education. Therefore, he spent a year with Prof. Florian Hollfelder's lab at the University of Cambridge before joining IISER Kolkata as an Assistant Professor.

You can reach him at: sb1[at]iiserkol.ac.in

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