Welcome to Dr. Rituparna Sinha Roy's Lab
IISER KOLKATA

Research Area:

Peptide based therapeutics, nanomedicine, drug delivery, biomimetic chemistry , chemical biology, supramolecular chemistry, applied biomaterials and cancer biology

Rituparna Sinha Roy is interested

Using biomimetic design strategies to develope novel molecules and therapeutic approach for biology and medicine. She is integrating protein engineering and nanotechnology for therapeutic purpose, with a special interest in cancer. Her research lies at the interface of chemistry, protein engineering , nanotechnology and medicine. She is developing platform technologies and tools for stabilizing and probing protein structure and function. Her research will focus on engineering stabilized biomolecules for therapy in the context of siRNA delivery, vaccine development and regenerative medicine.

ACADEMIC POSITIONS

2011 (May) – present: Assistant Professor at IISER Kolkata.

2007 –2011 (April): Postdococtoral Research Fellow
Harvard-MIT Division of Health Sciences and Technology,
Department of Medicine, Harvard Medical School.

2005 (Nov)– 2007 : Postdoctoral Research Associate
The Scripps Research Institute, San Diego

EDUCATION

1999 – 2005 :Ph.D (Conformational analysis of alpha-omega hybrid peptides)
Molecular Biophysics Unit, Indian Institute of Science, Bangalore

1997 – 1999 : M.Sc. in Chemistry(Physical Chemistry)
Jadavpur University

1994 – 1997 :B.Sc. (Chemistry Hons.)
Jadavpur University

AWARDS AND HONORS

2011: Ramalingaswamy award
2010: Travel Award ASPET (American Society for Pharmacology and Experimental Therapeutics)
2009: Postdoctoral Scientist Award (Cardiovascular Division, ASPET)
2006: Recipient of Shamrao Kaikini Medal for Best PhD Thesis (2005-2006),Indian Institute of Science, Bangalore, India.
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Dr. Rituparna Sinha Roy

Assistant Professor

Indian Institute of Science Education and Research Kolkata (IISER Kolkata)
Department of Biological Sciences
E-mail: rituparna@iiserkol.ac.in

Meet Our Team


Dr. Rituparna Sinha Roy

PI of the Lab, Assistant Professor


IISER Kolkata,Department of Biological Sciences

Chiranjit Dutta

PhD student

Chemistry Hons.; MSc Organic Chemistry

Snehasish Ghosh

PhD student

Chemistry Hons.; MSc Organic Chemistry

Abhijit Biswas

PhD student

Chemistry Hons.; MSc Organic Chemistry

Kasturee Chakraborty

PhD student

BSc Hons. (Microbiology), MSc: Biotechnology

Souvik Dey

PhD student

Chemistry Hons.; MSc Chemistry (project in organic chemistry)

Argho Mario Mallick

Student

BSc (Zoology); MSc (Zoology)

Dr. Sanchita Mukherjee

Having DBT Postdoctoral fellowship

BSc & MSc Chemistry,PhD in Computational Biology from SINP

Paramita Gayen

Project Assistant

BSc Hons. (Microbiology), MSc: Biotechnology

SELECTED RESEARCH PUBLICATIONS

Ghosh S , Mukherjee S, Dutta C, Chakraborty K, Gayen P, Jan S, Bhattacharyya D, Sinha Roy R(2017) Engineered isopeptide bond stabilized fibrin inspired nanoscale peptide based sealants for efficient blood clotting. Scientific Reports 7, 6509

Dutta C, Chakraborty K , Sinha Roy R* (2015). Engineered Nanostructured Facial Lipopeptide as Highly Efficient Molecular Transporter. ACS Appl Mater Interfaces 7, 18397-18405 .

Tao H, Lee SC, Moeller A, Roy RS, Siu FY, Zimmermann J, Stevens RC, Potter CS, Carragher B, Zhang Q. 2013. "Engineered nanostructured β-sheet peptides protect membrane proteins". Nat. Methods 10, 759-761.

Rituparna S. Roy*, B. Roy, S. Sengupta* (2011). Emerging technologies for enabling proangiogenic therapies. Nanotechnology 49, 494004.

A. Paraskar , S. Soni, S. Basu, CJ Amarasiriwardena, N Lupoli, S Srivats, Rituparna S Roy, S Sengupta (2011) Rationally engineered polymeric cisplatin nanoparticles for improved antitumor efficacy. Nanotechnology 22, 265101.

Rituparna S. Roy, S. Soni, R. Harfouche, P. R. Vasudevan, O. Homes, H. de Jonge, A. Rowe, A. Paraskar, D. M. Hentschel, E. Gherardi, R. A. Mashelkar, S. Sengupta (2010). Coupling growth factor engineering with nanotechnology for therapeutic angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 107, 13608-13613.

Rituparna S. Roy, H. N. Gopi, S. Raghothama, I. L Karle, P. Balaram (2006). Hybrid peptide hairpins containing α- and -amino acids: conformational analysis of decapeptides with unsubstituted β, and -residues at positions 3 and 8. Chemistry-A European Journal 12, 3295-3302.

A. Sengupta, Rituparna S. Roy, V. Sabareesh, N. Shamala, P. Balaram (2006). Aggregation modes in sheets formed by protected beta-amino acids and beta-peptides. Org Biomol Chem. 4, 1166-1173.

Rituparna S. Roy, H. N. Gopi, S. Raghothama, R. D. Gilardi, I. L Karle, P. Balaram (2005). Peptide hairpins with strand segments containing α- and β-amino acid residues: cross–strand aromatic interactions of facing Phe residues. Biopolymers (Peptide Science) 80, 787-799.

Rituparna S. Roy, I. L. Karle, S. Raghothama, P. Balaram (2004). α,β-Hybrid peptides: a polypeptide helix with a central segment containing two consecutive b-amino acid residues. Proc. Natl. Acad. Sci. U.S.A. 101, 16478 – 16482.

H. N. Gopi, Rituparna S. Roy, S. R. Raghothama, I. L. Karle, P. Balaram (2002). β-Hairpins generated from hybrid peptide sequences containing both a- and b-amino acids. Helv. Chim. Acta 85, 3313-3330.

Address:
Indian Institute of Science Education And Research Kolkata
Department of Biological Sciences
Research Complex
Room No-205
Mohanpur - 741 246,
West Bengal, India