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Research

Our main Research interest is the role of actin cytoskeleton in development and disease


Presently Working

1.Expression and functional characterization of formin family of proteins.
2.Molecular mechanisms of regulation of formin Delphilin activity.
3.Characterization of novel Formin binding proteins.
4.Isolation and characterization of novel actin binding proteins.
5.Role of formin in neurite outgrowth and synaptogenesis.

Development

Our approaches are various: use invitro and invio technique of molecular biology, cell biology, protein biochemistry and primary neuron culture to address the said research problems.

Consulting

Please write to me at
spm [at] iiserkol.ac.in
sankarmaiti73 [at] gmail.com

Publications

1. Dutta P, Das S & Maiti S. 2017 Non diaphanous formin delphilin acts as a barbed end capping protein. Exp Cell Res. 357(2):163-169

2. Maiti B, Dutta P, Seal S, Pal S, De P and Maiti S. 2017 Side-chain amino acid based cationic polymer induced actin polymerization. J. Mater. Chem. B, 2017,5, 1218-1226

3. Sutanu Kapri, Sankar Maiti, Sayan Bhattacharyya, (2016) Lemon grass derived porous carbon nanospheres functionalized for controlled and targeted drug delivery, Volume 100, Pages 222-235

4. Maiti, B.; Maiti, S.; De, P. (2016) Self-assembly of well-defined fatty acid based amphiphilic thermoresponsive random copolymers RSC Advances, 6, 19322-19330.

5. Jagmag SA, Tripathi N, Shukla SD, Maiti S, and Khurana S. (2016) Evaluation of models of parkinson's disease. Front. Neurosci. 9:503. 2016.

6. Dutta Priyanka and Sankar Maiti. (2015) Expression of Multiple Formins in Adult Tissues and During Developmental Stages of Mouse Brain.Gene Expr Patterns. 19(1-2):52-9

7. Kumar Nitesh, Somlata, Mazumder M, Dutta P, Maiti S and Gourinath S. (2014) EhCoactosin stabilizes actin filaments in the protist parasite Entamoeba histolytica. PLOS Pathogens. 2014, PPATHOGENS-D-14-00504R1.

8. Datta, A, Dutta P, Sadhu A, Maiti S and S Bhattacharyya, (2013) Single-step Scalable Conversion of Waste Natural Oils to Carbon Nanowhiskers and their Interaction with Mammalian Cells. J. Nanopart. Res. 15:180

9. Maiti S* and JR, Bamburg.* (2013) Actin Capping and Severing Proteins. Encyclopedia of Biological Chemistry. 2nd Edition in Press. Edited by William J. Lennarz, M. Daniel Lane. Academic Press. (* both are corresponding author).

10. Maiti S, Michelot A, Gould C, Blanchoin L, Sokolova O, Goode BL. (2012). Structure and activity of full-length formin mDia1. Cytoskeleton (Hoboken). 69:393-405.

11. Alam J, Maiti S, Ghosh P, De R, Chowdhury A, Das S, Macaden R, Devarbhavi H, Ramamurthy T, Mukhopadhyay AK. (2012) Signifiant association of the dupA gene of Helicobacter pylori with duodenal ulcer development in a South-east Indian population. J Med Microbiol. 61:1295-302.

12. Pal, S.; Das, A.; Maiti, S. and P De. (2012) Biodegradation and In-Vitro Biocompatibility of Polyperoxides: An Alternating Copolymers of Vinyl Monomers and Molecular Oxygen. Journal of Biomaterials Science, Polymer Edition, 23: 2105-2117.

13. Pal, S.; Das, A. Maiti, S and P. De. (2012) Synthesis and characterization of a biodegradable polymer prepared via radical copolymerization of 2-(acetoacetoxy)ethyl methacrylate and molecular oxygen. Polymer Chemistry, 3:182-189.

14. Gould CJ, Maiti S, Michelot A, Graziano BR, Blanchoin L and Goode BL. (2011) The Formin DAD Domain Plays Dual Roles in Autoinhibition and Actin Nucleation. Curr Biol.

15. Minamide LS, Maiti S, Boyle JA, Davis RC, Coppinger JA, Bao Y, Huang TY, Yates J, Bokoch GM, Bamburg JR. (2010) Isolation and characterization of cytoplasmic cofilin actin rods. J Biol Chem. 285:5450-60.

16. Lu J, Meng W, Poy F, Maiti S, Goode BL and Eck MJ (2007) Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly. J Mol Biol. 369:1258-69.

17. Moseley JB, Maiti S, and Goode BL. (2006) Formin proteins: purification and measurement of effects on actin assembly. Methods in Enzymology Chapter 16, Volume 406.

18. Juliana Soosairajah*, Sankar Maiti*, Patrick Sarmiere, Nathalie Moussi, O’Neil Wiggan, James R. Bamburg and Ora Bernard. (2005) The Interplay between LIM kinase1, Slingshot Phosphatase and F-actin Regulates the Phosphorylation of ADF/cofilin. EMBO J. 24(3):473-86. (* contributed eqully).

19. Maiti, S and JR Bamburg. (2004) Actin Capping and Severing Proteins. Encyclopedia of Biological Chemistry. Edited by William J. Lennarz, M. Daniel Lane.Academic Press September 2004.

20. Graber, S. Maiti, S. and Halpain S. (2004). Cathepsin B-like proteolysis and MARCKS degradation in sub-lethal NMDA-induced collapse of dendritic spines. Neuropharmacology. 47(5):706-13.

21. Alisa E. Shaw, Laurie S. Minamide, Christine L. Bill, Janel D. Fink, Sankar Maiti and James R. Bamburg. (2004). Cross-reactivity of antibodies to ADF/cofilin family proteins and identification of the major epitope recognized by a mammalian ADF/cofilin antibody. Electrophoresis, 25(15):2611-20.

22. Sadhu Leelavathi, Naveen Gupta, Shankar Maiti, Amit Ghosh and Vanga Siva Reddy. (2003)Overproduction of an alkali- and thermo-stable xylanase in tobacco chloroplasts and efficient recovery of the enzyme. Molecular Breeding. 11(1):59-67.

23. Maiti S, Luthra-Guptasarma M, Guptasarma P. (2002). Phenomenological perspectives on the folding of beta/alpha-barrel domains through the modular formation and assembly of smaller structural elements. IUBMB Life. 54(4): 213-21.

24. S. Chokraborty, P. Gurg, T. Ramamurthy, M. thungapatra, J. K. Gautam, C. Kumar, S. Maiti, S. Yamasaki, T. Shimada, Y. Takeda, A. Ghosh and G.B. Nair. (2001) Comparison ofantibiogram, virulance gene, ribotypes and DNA fingerprints of Vibrio cholerae of matching serogroups isolated from hospitalised diarrhoea cases and from the environment during 1997-1998 in calcutta, India. J. Med. Microbiol. 50: 879-888.

25. Gupta N, Reddy VS, Maiti S, Ghosh A. (2000) Cloning, expression, and sequence analysis of the gene encoding the alkali-stable, thermostable endoxylanase from alkalophilic, mesophilic Bacillus sp. Strain NG-27. Appl Environ Microbiol, 66(6): 2631-5.

26. Bag PK, Maiti S, Sharma C, Ghosh A, Basu A, Mitra R, Bhattacharya SK, Nakamura S, Yamasaki S, Takeda Y, Balakrish Nair G. (199 Rapid spread of the new clone of Vibrio cholerae O1 biotype El Tor in cholera endemic areas in India. Epidemiol Infect 121(2): 245-51.

27. Sharma C, Maiti S, Mukhopadhyay AK, Basu A, Basu I, Nair GB, Mukhopadhyaya R, Das B, Kar S, Ghosh RK, Ghosh A. (1997) Unique organization of the CTX genetic element in Vibrio cholerae O139 strains which reemerged in Calcutta, India, in September 1996. J Clin Microbiol, 35(12): 3348-50.

Lab Projects


Our main Research interest is the role of actin cytoskeleton regulation in development and disease: (Page Under Construction)

1.Expression and functional characterization of formin family of proteins.
2.Molecular mechanisms of regulation of formin Delphilin activity.
3.Characterization of novel Formin binding proteins.
4.Isolation and characterization of novel actin binding proteins.
5.Role of formin in neurite outgrowth and synaptogenesis.



Meet Our Team

..

Team Member
Dr. Sankar Maiti

Assistant Professor

IISER Kolkata

Email: spm [at] iiserkol.ac.in

Dr. Sankar Maiti

Group Leader
Team Member
Dr. Soma Seal

DST SERB N-PDF

IISER Kolkata

Email: somaseal2@gmail.com

Dr. Soma Seal

Post Doctoral Fellow
Team Member
Swagata Das

Integrated-PhD Scholar

IISER Kolkata

Email: swagata91@gmail.com

Swagata Das

Integrated-PhD Scholar
Team Member
Shail Adrian Jagmag

PhD research scholar

IISER Kolkata

Email: adrianjagmag@gmail.com

Shail Adrian Jagmag

PhD research scholar
Team Member
Mandip Pratham Gadpayle

PhD research scholar

IISER Kolkata

Email: mandipgadpayle@gmail.com

Mandip Pratham Gadpayle

PhD research scholar
Team Member
Renu Kushwaha

PhD research scholar

IISER Kolkata

Email: mushkankushwaha29@gmail.com

Renu Kushwaha

PhD research scholar
Team Member
Biswaprakash Mahanta

BS-MS Student

IISER Kolkata

Email: biswaprakash2006rta@gmail.com

Biswaprakash Mahanta

BS-MS Student

Alumni

Dr. Priyanka Dutta
PhD Student at SM's Lab
Present: DBT Research Associate IISER Pune
Email: priyanka.dut1000@gmail.com

Mr. Jijumon AS
MS Student at SM's Lab
Present: PhD Student at Institute Curie, France
Email: jijumon109@gmail.com

Ms. CHINCHUMOL K SABU
MS Student at SM's Lab

Ms. Drisya Dileep MS Student at SM's Lab
Present: CSIR-JRF at NCBS
Email: drisya.dileep2@gmail.com

Ms. Reshmi P B
MS Student at SM's Lab

Ms. Meekha George
MS Student at SM's Lab

Let’s Discuss

Actin Regulation at Leading Edge

Indian Institute of Science Education And Research Kolkata

Mohanpur - 741246

West Bengal, India

Telephone Number of Office:
+91-33-66340000, Ext. 1215