Partho Sarothi Ray
Ph. D.- Biology (IISc, Bangalore, 2005)
Area of Interest:
Molecular Biology, Translational Control, Inflammation and Cancer Biology
Translational control of gene expression in cellular and viral systems, RNA-protein interactions, microRNA-mediated regulation of gene expression in inflammation and cancer, molecular evolution
- Ph.D from the Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 2005.
- Post-doctoral fellow in the Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, October 2004 to January, 2008.
Awards and Honors:
- Wellcome Trust-DBT India Alliance intermediate fellowship, 2010.
- Associate, Indian Academy of Sciences, 2010.
- Fellowship Lecture Award to the Cold Spring Harbor Symposium on Quantitative Biology, 2009: “Evolution: The molecular Landscape”.
- The Elsa Albrecht Fellow Award, 2008, from the Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, USA.
- The F. Merlin Bumpus Junior Investigator Award, 2007 from the Lerner Research Institute, Cleveland Clinic, Cleveland, USA.
- The Lower Award for excellence in non-clinical research, 2007 (second position), from the Cleveland Clinic, Cleveland, USA.
- The Tarazi Award for excellence in cardio-vascular research, 2007 (second position), from the Cleveland Clinic, Cleveland, USA.
- The Elsa Albrecht Fellow Award, 2007, (second position) from the Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, USA.
- The Sreenivasaya Medal for the year 2004-05, for the best Ph.D thesis from the department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
- Postdoctoral Travel Award to Experimental Biology, 2006, by the American Society for Biochemistry and Microbiology.
List of Publications:
- Yao P., Potdar A.A., Arif A., Ray P.S., Mukhopadhyay R., Willard B., Xu Y., Yan J., Saidel G.M. and Fox P.L. (2012) Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression. Cell 149, 88-100. (Epub 2012 Mar 1)
- Ray P.S., Sullivan J.C., Jia J., Francis J., Finnerty J.R. and Fox P.L.(2011) Evolution of Function of a Fused Metazoan tRNA Synthetase. Mol Biol Evol. 28, 437-447. (Epub 2010 Sep 9).
- Chaudhury A., Hussey G.S., Ray P.S., Jin G., Fox P.L. and Howe P.H. (2010) Transforming growth factor-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript selective translational induction of Dab2 and ILE1. Nature Cell Biol. 12, 286-293 (Epub 2010 Feb 14).
- Mukhopadhyay R., Jia J., Arif A., Ray P.S. and Fox P.L. (2009) The GAIT system: A gatekeeper of inflammatory gene expression. Trends Biochem Sci. 34, 324-31.
- Ray P.S., Jia J., Yao P., Majumder M., Hatzoglou M. and Fox P.L. (2009) A stress responsive RNA switch regulates VEGFA expression. Nature 457, 915-919. (Epub 2008 Dec 21) (Commentaries in Nature, Cell–RNA Select, Science–Signaling, Nature Signaling Update, Nature Reviews in Genetics, ACS Chemical Biology, Nature India and Faculty of 1000_Biology)
- Mukhopadhyay R., Ray P.S., Arif A., Brady A.K., Kinter M. and Fox P.L. (2008) DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. Mol. Cell 32, 371-382.
- Jie J., Arif A, Ray P.S. and Fox P. L. (2008) WHEP domains direct non-canonical function of Glutamyl-prolyl tRNA synthetase in translational control of gene expression. Mol. Cell 29, 679-690.
- Grover R., Ray P.S. and Das S. (2008) Polypyrimidine tract-binding protein regulates IRES-mediated translation of p53 isoforms. Cell Cycle 7, 2189-2198.
- Ray P.S. and Fox P. L. (2007) A post-transcriptional pathway represses monocyte VEGF-A expression and angiogenic activity. EMBO J 26, 3360-3372.
- Ray P.S., Arif A. and Fox P.L. (2007) Macromolecular complexes as depots for releasable regulatory proteins. Trends Biochem Sci 32, 158-164.
- Ray P.S, Grover R and Das S. (2006) Two internal ribosome entry sites mediate the translation of p53 isoforms. EMBO Rep. 7, 404-410.
- Ray P.S. and Fox P.L. (2005) Equality of the sexes: found in translation. Cell 122, 492-493.
- Ray P.S and Das S. (2004) Inhibition of Hepatitis C virus IRES-mediated translation by small RNAs analogous to stem-loop structures of the 5’untranslated region. Nucleic. Acids Res. 32, 1678-1687.
- Venkatramana M.#, Ray P.S.#, Chadda A. and Das. S (2003) A 25 kDa cleavage product of polypyrimidine tract binding protein (PTB) present in mouse tissues prevents PTB binding to the 5' untranslated region and inhibits translation of hepatitis A virus RNA. Virus Res. 98, 141-149. (#Joint first authors)
- Seshagiri P.B., Thomas M., Sreekumar, A. Ray P. and Mariappa, D. (2003) Pentoxifylline induced signaling events during capacitation of hamster spermatozoa: significance of protein tyrosine phosphorylation. Cell. Mol. Biol. 49, 371-380.
- Ray P.S. and Das S. (2002) La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA. Nucleic. Acids Res. 30, 4500-4508.