A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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Partho Sarothi Ray

PhD:
Ph. D.- Biology (IISc, Bangalore, 2005)
Area of Interest:
Molecular Biology, Translational Control, Inflammation and Cancer Biology
Email ID:
psray
Research Interest:

Translational control of gene expression in cellular and viral systems, RNA-protein interactions, microRNA-mediated regulation of gene expression in inflammation and cancer, molecular evolution

Academic Qualification:
  1. Ph.D from the Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 2005.
Positions:
  1. Post-doctoral fellow in the Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, October 2004 to January, 2008.

Awards and Honors:

  1. Wellcome Trust-DBT India Alliance intermediate fellowship, 2010.
  2. Associate, Indian Academy of Sciences, 2010.
  3. Fellowship Lecture Award to the Cold Spring Harbor Symposium on Quantitative Biology, 2009: “Evolution: The molecular Landscape”.
  4. The Elsa Albrecht Fellow Award, 2008, from the Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, USA.
  5. The F. Merlin Bumpus Junior Investigator Award, 2007 from the Lerner Research Institute, Cleveland Clinic, Cleveland, USA.
  6. The Lower Award for excellence in non-clinical research, 2007 (second position), from the Cleveland Clinic, Cleveland, USA.
  7. The Tarazi Award for excellence in cardio-vascular research, 2007 (second position), from the Cleveland Clinic, Cleveland, USA.
  8. The Elsa Albrecht Fellow Award, 2007, (second position) from the Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, USA.
  9. The Sreenivasaya Medal for the year 2004-05, for the best Ph.D thesis from the  department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
  10. Postdoctoral Travel Award to Experimental Biology, 2006, by the American Society for Biochemistry and Microbiology.
List of Publications:

  1. Yao P., Potdar A.A., Arif A., Ray P.S., Mukhopadhyay R., Willard B., Xu Y., Yan J., Saidel G.M. and Fox P.L. (2012) Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression. Cell 149, 88-100. (Epub 2012 Mar 1)
  2. Ray P.S., Sullivan J.C., Jia J., Francis J., Finnerty J.R. and Fox P.L.(2011) Evolution of Function of a Fused Metazoan tRNA Synthetase. Mol Biol Evol. 28, 437-447. (Epub 2010 Sep 9).
  3. Chaudhury A., Hussey G.S., Ray P.S., Jin G., Fox P.L. and Howe P.H. (2010) Transforming growth factor-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript selective translational induction of Dab2 and ILE1. Nature Cell Biol. 12, 286-293 (Epub 2010 Feb 14).
  4. Mukhopadhyay R., Jia J., Arif A., Ray P.S. and Fox P.L. (2009) The GAIT system: A gatekeeper of inflammatory gene expression. Trends Biochem Sci. 34, 324-31.
  5. Ray P.S., Jia J., Yao P., Majumder M., Hatzoglou M. and Fox P.L. (2009) A stress responsive RNA switch regulates VEGFA expression. Nature 457, 915-919. (Epub 2008 Dec 21) (Commentaries in Nature, Cell–RNA Select, Science–Signaling, Nature Signaling Update, Nature Reviews in Genetics, ACS Chemical Biology, Nature India and Faculty of 1000_Biology)
  6. Mukhopadhyay R., Ray P.S., Arif A., Brady A.K., Kinter M. and Fox P.L. (2008) DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. Mol. Cell 32, 371-382.
  7. Jie J., Arif A, Ray P.S. and Fox P. L. (2008) WHEP domains direct non-canonical function of Glutamyl-prolyl tRNA synthetase in translational control of gene expression. Mol. Cell 29, 679-690.
  8. Grover R., Ray P.S. and Das S. (2008) Polypyrimidine tract-binding protein regulates IRES-mediated translation of p53 isoforms. Cell Cycle 7, 2189-2198.
  9. Ray P.S. and Fox P. L. (2007) A post-transcriptional pathway represses monocyte VEGF-A expression and angiogenic activity. EMBO J  26, 3360-3372.
  10. Ray P.S., Arif A. and Fox P.L. (2007) Macromolecular complexes as depots for releasable regulatory proteins. Trends Biochem Sci 32, 158-164.
  11. Ray P.S, Grover R and Das S. (2006) Two internal ribosome entry sites mediate the translation of p53 isoforms. EMBO Rep. 7, 404-410.
  12. Ray P.S. and Fox P.L. (2005) Equality of the sexes: found in translation. Cell 122, 492-493.
  13. Ray P.S and Das S. (2004) Inhibition of Hepatitis C virus IRES-mediated translation by small RNAs analogous to stem-loop structures of the 5’untranslated region. Nucleic. Acids Res. 32, 1678-1687.
  14. Venkatramana M.#, Ray P.S.#, Chadda A. and Das. S (2003) A 25 kDa cleavage product of polypyrimidine tract binding protein (PTB) present in mouse tissues prevents PTB binding to the 5' untranslated region and inhibits translation of hepatitis A virus RNA. Virus Res. 98, 141-149. (#Joint first authors)
  15. Seshagiri P.B., Thomas M., Sreekumar, A. Ray P. and Mariappa, D. (2003) Pentoxifylline induced signaling events during capacitation of hamster spermatozoa: significance of protein tyrosine phosphorylation. Cell. Mol. Biol. 49, 371-380.
  16. Ray P.S. and Das S. (2002) La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA. Nucleic. Acids Res. 30, 4500-4508.