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Photoredox catalysis has been revolutionized modern organic synthesis by introducing radical-
based transformation under mild, sustainable condition utilizing visible light.1 Through single
electron transfer (SET) and energy transfer (EnT), it facilitates the activation of inert bond and
the construction of complex molecular structure. The integration of photoredox catalysis with
transition metal catalysis and Lewis’s acid catalysis unlock dual catalytic system, empowering
productive synthetic methodology as well as enantioselective synthesis. These advancement
offers significant benefits in terms of green chemistry, energy efficient process and lowering
the waste.
In order to avoid the generation of metallic waste and highly reactive organometallic reagents,
we have developed a sustainable method for 1,2-dicarbofunctionalization of unactivated alkene
via synergistic halogen atom transfer and photoredox/nickel dual catalysis under visible light
to efficiently form two new carbon-carbon bonds in a single step (Figure 1).
2 The method
accommodates a wide range of alkyl and aryl electrophiles, tolerates different functional
groups, and is especially valuable for the late-stage modification of pharmaceuticals and
bioactive compounds. Mechanistic studies indicate that α-amino radicals are crucial in the
halogen atom transfer mechanism, and that particular nickel complexes are vital for the
catalytic cycle, rendering this approach both adaptable and environmentally friendly. |