| Description: | [NNMCB Seminar] Prof. Debashish Chowdhury (Department of Physics, Indian Institute of Technology, Kanpur) -- Motor-driven Stochastic Processes in a Living Cell: Statistical Physics Far From Equilibrium |
| Date: | Thursday, Oct 08, 2015 |
| Time: | 4 p.m. - 5:30 p.m. |
| Venue: | G02, Lecture Hall Complex |
| Details: | Microtubule is nature's nano-tube that forms various non-covalent attachments whose lifetimes are determined by thermally-assisted crossing of unusual effective energy barriers. We present a quantitative theory, based on "first-passage time" calculation, for force-induced alterations of the barrier and the consequent changes in the stability of the attachment. Microtubules serve as tracks for cytoskeletal motor proteins. Polymerases and ribosomes are also molecular motors; these synthesize linear hetero-polymers while motoring along the respective nucleic acid template strands. The collective movement of the motors on the corresponding tracks are described as traffic of interacting self-driven rods, each with internal stochastic chemo-mechanical kinetics. Following this approach we have developed models of poly-ribosomes (polysomes) and transcriptional interference; I'll present a non-technical summary of these works. |
| Calendar: | Seminar Calendar (entered by ritesh.singh) |