| Description: | [DPS Seminar] Prof. Dibyendu Das (IIT, Mumbai) -- First Passage, non-monotonic fluctuations, and biological timekeeping. -::~::- Join: https://meet.google.com/dfs-vguy-czr -::~::- |
| Date: | Wednesday, Apr 13, 2022 |
| Time: | 3 p.m. - 4 p.m. |
| Details: | Stochastic processes in physical and biological systems are often terminated by first arrival to a target, an event famously referred to as the First Passage. I will start with an experimental work on transport of a self-propelled particle among passive crowders, where we found the fluctuations in the time of first passage to be non-monotonic with crowder density. Then I will move on to discuss a class of first passage events that arise in biological systems. Such events are generically associated with certain crucial proteins (like Holin, Pnemolysin, or FtsZ) crossing a threshold number or concentration. A couple of mathematical problems associated with gene expression and protein threshold crossing have been recently solved by us. Interestingly our theoretical results explain the experimentally observed non-monotonic relative fluctuations of lysis times of bacteriophage-lambda mutants as a function of mean lysis times. |
| URL: | https://meet.google.com/dfs-vguy-czr |
| Calendar: | Seminar Calendar (entered by rajni) |