Rahul Das

Assistant Professor
Dept: Biological Sciences (DBS)
E-mail: rahul.das [at] iiserkol.ac.in
Personal homepage: Click Here

Research Interest:
 

The main interest of our laboratory is to understand the mechanism of signal transduction across the plasma membrane. We are particularly interested in understanding how the signal transduce across the plasma membrane by membrane-associated proteins kinases like ZAP-70 found in T-Cells and transmembrane receptors like VEGF receptors, respectively. Kinases are known to function as dynamic signaling switches, however they are not turned on (active state) and off (inactive state) by one factor. How kinases toggle between an inactive conformations to an active conformation has been the subject of many studies. It is believed that an intricate circuitry of intra- and inter-molecular allosteric networks (mainly through non-covalent interactions) present in the regulatory and the catalytic modules control the kinase activity. The molecular details of how these non-covalent interactions influence the transition from an inactive state to an active state are not completely understood. We use NMR spectroscopy to study the structure and dynamics of membrane-associated kinases involved in cellular signaling and combine Biochemical analysis to find out how they work.

Academic Background:

  1. Ph.D. (Structural Biology), (McMaster University, Canada), 2008
  2. M.Tech. (Biotech and Biochem Engg), (IIT Khargpur), 2000

Positions:

  1. Assistant Professor, IISER Kolkata ( - )
  2. Postdoctoral Fellow, University of California, Berkeley (2009 - 2014)
  3. Research Associate, Wockhardt Research Centre (2000 - 2001)

Awards and Honors:

  1. Early Career Award from SERB (2016)
  2. Ramalingaswami Re-entry Fellowship from DBT (2016)
  3. CIHR Postdoctoral Fellowship from Canadian Institutes of Health Research (2011)
  4. NSERC Postdoctoral Fellowship from Natural Sciences and Engineering Research Council, Canada (2009)
  5. Impact Award from McMaster University, Canada (2007)
  6. Research Scholarship from McMaster University, Canada (2004)

Selected Publications:

  1. Sharma, R; Kumar, P; Kaushal, V; Das, R and Navani, N Kumar. 2018."A novel protein tyrosine phosphatase like phytase from Lactobacillus fermentum NKN51: Cloning, characterization and application in mineral release for food technology applications.." Bioresour Technol, 249, 1000-1008
  2. Kovacs*, E; Das*, R; Wang, Q; Collier, T S; Cantor, A; Huang, Y; Wong, K; Mirza, A; Barros, T; Grob, P; Jura, N; Bose, R and Kuriyan, J. 2015."Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor." Mol Cell Biol, 35, 3083-3102
  3. Iwig, J S; Vercoulen*, Y; Das*, R; Barros, T; Limnander, A; Che, Y; Pelton, J G; Wemmer, D E; Roose, J P and Kuriyan, J. 2013."The structural basis for autoinhibition of thr Ras-specific exchange factor RasGRP1." eLife, ,
  4. Endres*, N; Das*, R; Smith, A W; Arkhipov, A; Kovacs, E; Huang, Y; Pelton, J G; Shan, Y; Shaw, D E; Wemmer, D E; Groves, J T and Kuriyan, J. 2013."Conformational coupling across the plasma membrane in activation of the EGF receptor.." Cell, 152, 543 – 556
  5. Das, R; Esposito, V; Abu-Abed, M; Anand, G S; Taylor, S S and Giuseppe, M. 2007."cAMP activation of PKA defines an ancient signaling mechanism." Proceedings of National Academy of Sciences U.S.A., 104, 93-98

All Publications: Click Here