Welcome to Dr. Rituparna Sinha Roy's Lab
IISER KOLKATA

Research Area:

Laboratory for Nanomedicine and Biomedical Engineering
Peptide based therapeutics, cancer nanomedicine, regenerative nanomedicine, drug delivery, chemical biology, applied biomaterials , cancer biology, blood clotting, wound healing

Rituparna Sinha Roy is interested

Using biomimetic design strategies to develope novel molecules and therapeutic approach for biology and medicine. She is integrating protein engineering and nanotechnology for therapeutic purpose, with a special interest in cancer. Her research lies at the interface of chemistry, protein engineering , nanotechnology and medicine. She is developing platform technologies and tools for stabilizing and probing protein structure and function. Her research will focus on engineering stabilized biomolecules for therapy in the context of siRNA delivery, vaccine development and regenerative medicine.

ACADEMIC POSITIONS

2018 (Sep) – Present: Associate Professor at IISER Kolkata.

2011 (May) – 2018 (Sep): Assistant Professor at IISER Kolkata.

2007 –2011 (April): Postdococtoral Research Fellow
Harvard-MIT Division of Health Sciences and Technology,
Department of Medicine, Harvard Medical School.

2005 (Nov)– 2007 : Postdoctoral Research Associate
The Scripps Research Institute, San Diego

EDUCATION

1999 – 2005 :Ph.D (Conformational analysis of alpha-omega hybrid peptides)
Molecular Biophysics Unit, Indian Institute of Science, Bangalore

1997 – 1999 : M.Sc. in Chemistry(Physical Chemistry)
Jadavpur University

1994 – 1997 :B.Sc. (Chemistry Hons.)
Jadavpur University

AWARDS AND HONORS

2019: Editorial Advisory Board Member ACS Applied Bio Materials
2018: Executive Council Member Indian Chemical Biology
2011: Ramalingaswamy award
2010: Travel Award ASPET (American Society for Pharmacology and Experimental Therapeutics)
2009: Postdoctoral Scientist Award (Cardiovascular Division, ASPET)
2006: Recipient of Shamrao Kaikini Medal for Best PhD Thesis (2005-2006),Indian Institute of Science, Bangalore, India.
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Dr. Rituparna Sinha Roy

Associate Professor

Indian Institute of Science Education and Research Kolkata (IISER Kolkata)
Department of Biological Sciences
Centre for Advanced Functional Materials
Center for Climate & Environmental Studies
E-mail: rituparna@iiserkol.ac.in

Meet Our Team


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Asmita Mukherjee

PhD student

Microbiology Hons.; MSc Biotechnology

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Somnath Jan

PhD student

BSMS IISER Kolkata

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Sukumar Mishra

PhD student

BSc & MSc Zoology

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Snehasish Ghosh

PhD student

Chemistry Hons.; MSc Organic Chemistry

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Abhijit Biswas

PhD student

Chemistry Hons.; MSc Organic Chemistry

Abhijit Biswas

Kasturee Chakraborty

PhD student

BSc Hons. (Microbiology), MSc: Biotechnology

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Argha Mario Mallick

PhD student

BSc (Zoology); MSc (Zoology)

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Archana Tripathi

PhD Student

BSc & MSc Human Physiology

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Paramita Gayen

PhD student

BSc Hons. (Microbiology), MSc: Biotechnology

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Sujay Ray

Project Attendant

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Alumni

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Chiranjit Dutta

Postdoc at National University of Singapore

BSc Hons. Chemistry, MSc: Organic Chemistry

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Dr. Sanchita Mukherjee

Development editor – editorial outreach
& American Chemical Society

BSc & Msc Chemistry

Souvik Dey

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Chemistry Hons.; MSc Chemistry (project in organic chemistry)

SELECTED RESEARCH PUBLICATIONS

Biswas, A.; Chakraborty, K.; Dutta, C.; Mukherjee, S.; Gayen, P.; Jan, S; Mallick, A.M. ; Bhattacharyya, D.*; Sinha Roy, R*. Engineered Histidine-enriched Facial Lipopeptides for Enhanced Intracellular Delivery of Functional siRNA to Triple Negative Breast Cancer Cells. ACS Appl. Mater. Interfaces, 2019, 11, 4719-4736.

Chakraborty, K.; Dutta, C.; Mukherjee, S.; Biswas, A.; Gayen, P.; George, G.; Raghothama, S.; Ghosh, S.; Dey, S.; Bhattacharyya, D.*; Sinha Roy, R*. Engineering Ionophore Gramicidin-Inspired Self-Assembled Peptides for Drug Delivery and Cancer Nanotherapeutics. Adv. Therapeut. 2018, 1800018. (selected for journal cover page)

Ghosh, S.; Mukherjee, S.; Dutta, C.; Chakraborty, K.; Gayen, P.; Jan, S.; Bhattacharyya, D.*; Rituparna Sinha Roy*, Engineered Isopeptide Bond Stabilized Fibrin Inspired Nanoscale Peptide Based Sealants for Efficient Blood Clotting. Sci. Rep., 2017, 7, 6509.

Dutta C, Chakraborty K , Sinha Roy R* (2015). Engineered Nanostructured Facial Lipopeptide as Highly Efficient Molecular Transporter. ACS Appl Mater Interfaces 7, 18397-18405 .

Tao H, Lee SC, Moeller A, Roy RS, Siu FY, Zimmermann J, Stevens RC, Potter CS, Carragher B, Zhang Q. 2013. "Engineered nanostructured β-sheet peptides protect membrane proteins". Nat. Methods 10, 759-761.

Rituparna S. Roy*, B. Roy, S. Sengupta* (2011). Emerging technologies for enabling proangiogenic therapies. Nanotechnology 49, 494004.

A. Paraskar , S. Soni, S. Basu, CJ Amarasiriwardena, N Lupoli, S Srivats, Rituparna S Roy, S Sengupta (2011) Rationally engineered polymeric cisplatin nanoparticles for improved antitumor efficacy. Nanotechnology 22, 265101.

Rituparna S. Roy, S. Soni, R. Harfouche, P. R. Vasudevan, O. Homes, H. de Jonge, A. Rowe, A. Paraskar, D. M. Hentschel, E. Gherardi, R. A. Mashelkar, S. Sengupta (2010). Coupling growth factor engineering with nanotechnology for therapeutic angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 107, 13608-13613.

Rituparna S. Roy, H. N. Gopi, S. Raghothama, I. L Karle, P. Balaram (2006). Hybrid peptide hairpins containing α- and -amino acids: conformational analysis of decapeptides with unsubstituted β, and -residues at positions 3 and 8. Chemistry-A European Journal 12, 3295-3302.

A. Sengupta, Rituparna S. Roy, V. Sabareesh, N. Shamala, P. Balaram (2006). Aggregation modes in sheets formed by protected beta-amino acids and beta-peptides. Org Biomol Chem. 4, 1166-1173.

Rituparna S. Roy, H. N. Gopi, S. Raghothama, R. D. Gilardi, I. L Karle, P. Balaram (2005). Peptide hairpins with strand segments containing α- and β-amino acid residues: cross–strand aromatic interactions of facing Phe residues. Biopolymers (Peptide Science) 80, 787-799.

Rituparna S. Roy, I. L. Karle, S. Raghothama, P. Balaram (2004). α,β-Hybrid peptides: a polypeptide helix with a central segment containing two consecutive b-amino acid residues. Proc. Natl. Acad. Sci. U.S.A. 101, 16478 – 16482.

H. N. Gopi, Rituparna S. Roy, S. R. Raghothama, I. L. Karle, P. Balaram (2002). β-Hairpins generated from hybrid peptide sequences containing both a- and b-amino acids. Helv. Chim. Acta 85, 3313-3330.

Book Chapter
Title of the chapter: Emerging Peptide based Technologies in Cancer Therapy Argha Mario Mallick, Kasturee Chakraborty, Abhijit Biswas, Somnath Jan, Chiranjit Dutta, Souvik Dey, Suprabhat Sahoo, Kishan Mandal, Rituparna Sinha Roy* ISBN 978-981-32-9815-6 ; Springer https://www.springer.com/in/book/9789813298156

Student Achievement


Oral presentation by Kasturee Chakraborty: Indo-Australian Symposium on “Epithelial-Mesenchymal Transition” at NCCS Pune, 2018

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News:


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Please see the following links.:
1. https://indiabioscience.org/news/2017/nature-inspired-artifical-peptides-for-faster-blood-clotting
2. http://www.thehindubusinessline.com/news/science/scientists-develop-natural-material-for-faster-blood-clotting/article9824598.ece
3. http://www.vigyanprasar.gov.in/isw/bloodcloting_story.html
4. https://www.outlookindia.com/website/story/scientists-develop-natural-material-for-faster-blood-clotting/300421
5. http://www.biospectrumindia.com/news/58/9401/scientists-develop-biomaterial-for-faster-blood-clotting.html
6. https://newsroom24x7.com/2017/08/16/scientists-develop-natural-material-for-faster-blood-clotting/
7. http://epaper.jagran.com/epaperimages/17082017/delhi/16ned-pg14-0.pdf
8. http://medicarepharmabusiness.com/bleeding-tide-in-hemophiliacs-can-easily-be-stemmed-now/
9. http://www.downtoearth.org.in/news/scientists-develop-natural-material-for-faster-blood-clotting-58487
10. https://biotechtimes.org/2017/08/16/indian-scientists-develop-peptide-based-sealant-faster-blood-clotting/
11. http://www.indiansciencejournal.in/health-news/scientists-develop-natural-material-for-faster-blood-clotting-215595
12. https://www.biovoicenews.com/scientists-develop-natural-material-faster-blood-clotting/
Address:
Indian Institute of Science Education And Research Kolkata
Department of Biological Sciences
Research Complex
Room No-E245
Mohanpur - 741 246,
West Bengal, India