IISER Kolkata - Department of Biological Sciences
Our research focuses on understanding epigenetic mechanisms, protein engineering, and photochemical approaches to study chromatin dynamics in human health and disease.
Learn MoreAssociate Professor
Department of Biological Sciences
Indian Institute of Science Education and Research Kolkata
Dr. Sudhamalla's research focuses on epigenetic mechanisms including reversal of DNA methylation and epigenetic readers/erasers of histone acetylation. His lab uses multidisciplinary approaches including protein engineering, unnatural amino acid mutagenesis, and mechanistic biochemistry to understand epigenetic mechanisms in human health and disease.
Associate Professor, IISER Kolkata
IISER Kolkata (2018-2024)
University of Pittsburgh, USA (2014-2018)
University of Hyderabad, Hyderabad (2014)
University of Hyderabad, Hyderabad (2009)
JNTU, Hyderabad (2006)
The research in our laboratory focuses on epigenetic mechanisms that are at best partially understood: (i) reversal of DNA methylation (ii) epigenetic readers and erasers of histone acetylation. Dysregulation in these processes can cause chromosomal instability, and eventually lead to multiple disorders including cancer and neurological diseases.
We investigate the molecular rationale linking epigenetic events to disease states, particularly how mutations in various gene products play roles in tumorigenesis, tumor progression, and metastasis.
We focus on the expansion of the genetic code: genetic incorporation of unnatural amino acids into proteins in live cells and their applications.
We develop photochemical approaches toward understanding epigenetic mechanisms in human biology and disease.
To address these questions, we take a multidisciplinary approach that integrates protein engineering, unnatural amino acid mutagenesis, mechanistic biochemistry, mammalian cell culture systems, proteomics, and bioinformatics to interrogate cellular machineries toward a molecular understanding of epigenetic mechanisms in human health and disease.
Postdoctoral Researcher at the Institute of Molecular Medicine, Denmark
Postdoctoral Associate at UT Southwestern Medical Center, Texas, USA
Postdoctoral Associate at National Institute on Aging-NIH, Baltimore, USA
Graduate student at the University of Stuttgart, Germany
Project Assistant at Lund University, Sweden
Project Based Student Trainee at CCMB, Hyderabad
Graduate student at University of North Carolina Chapel Hill (UNCCH) USA
System Engineer at Tata Consultancy Services, Kolkata
Project Associate, CSIR, IICT Hyderabad
Graduate student at the University of Göttingen, Germany
Congratulations to Dr. Ishita Bardhan on starting her postdoctoral research position at the Institute for Molecular Medicine, Denmark from July 14, 2025.
Ms. Yogita Yadav has been awarded the International Disease Models & Mechanisms Conference Travel Grant (CTG-DMM25022022) from The Company of Biologists Limited and will attend to present a poster at the Gordon Research Conference on Cancer Genetics and Epigenetics 2025, held from May 17-23, 2025, at Renaissance Tuscany Il Ciocco, Lucca (Barga), Italy..
Ms. Ishita Bardhan (PhD Student) received the International Travel Support (ITS) grant from SERB (Grant Number: ITS/2023/004259) to attend and present her poster in the 1st Epigenetics Society (ES) International Meeting: Epigenetics of Disease and Development, Rome, Italy, October 12-14 2023.
Ms. Jyotirmayee Padhan (PhD Student) has been selected for the prestigious "Prime Minister's Research Fellowship 2022.
Department of Biological Sciences
Teaching and Research Complex, 2nd Floor, Room No. N-211
Indian Institute of Science Education and Research Kolkata
Mohanpur, Nadia-741246, West Bengal, India.
+91-33-61360000, Ext:1337 (Office)
+91-33-61360000, Ext:1526 (Lab)
s.babu@iiserkol.ac.in