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Research Area: |
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Self-assembly of peptides and peptidomimetics.
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Peptide based nanostructured materials have drawn a significant amount of attention due to their novel properties. Different kinds of peptide based self-assembled architectures have been constructed in our lab during the past decade.
- Formation of toroid by self-assembly of a-a corner mimetic: supramolecular cyclization. D. Podder, S. Bera, M. Debnath, T. Das and Debasish Haldar*. J. Materials. Chem. B, 2017, 5, 7583-7590. DOI: 10.1039/C7TB01711A.
- A self-assembled peptide mimetic of a tubular host and a supramolecular polymer. A. Paikar, A. Pramanik, T. Das and Debasish Haldar*. Polymer Chemistry. 2017, 8, 396-403. DOI: 10.1039/C6PY01955B.
- Self-assembled peptide microspheres for sustainable release of sulfamethoxazole. A. Pramanik, A. Paikar, T. Das, K. Maji and Debasish Haldar*. RSC Advances. 2016, 6, 39172-39179. DOI: 10.1039/C5TA08010J.
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Self-aggregating systems from pharmaceutical molecules as delivery vehicles and sustained release.
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Amino acid-based drug carriers in particular are useful due to their biocompatibility, recognition properties and hydrophilic-hydrophobic balance for solubilizing and targeted delivery of highly hydrophobic antitumour and anti-depressant drugs and statins. Unprecedented functional and structural diversity can be achieved from synthetic non-coded amino acids with well-defined stereochemical and functional properties.
- Fabrication of egg shell like nanovesicles from thiocoumarin based e-amino ester: a potential carrier. M. Debnath, S. Sasmal and Debasish Haldar*. J. Mat. Chem B, 2017, 5 5450-5457. DOI: 10.1039/C7TB00025A
- Self-assembled peptide microspheres for sustainable release of sulfamethoxazole. A. Pramanik, A. Paikar, T. Das, K. Maji and Debasish Haldar*. RSC Advances. 2016, 6, 39172-39179. DOI: 10.1039/C5TA08010J.
- Fabrication of self-assembled peptidomimetic microspheres and hydrogen peroxide responsive release of nicotinamide. S. K. Maity, S. Bera, A. Paikar, A. Pramanik and Debasish Haldar*. CrystEngComm, 2014, 16 2527-2534. DOI: 10.1039/C3CE41796D
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Stimuli responsive foldamer.
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Over the past few years, considerable progress has been achieved in the design, synthesis and characterization of artificial oligomers that can wind around one another based on the intrinsic nature of the foldamers. In this regard, we are interested in designing some foldamers.
- C-Terminal-Aib-L-Leu-OMe Segment promotes Schellman Loop in the crystal state from α-Peptides with Alternating L-Leu and Aib Residues. M. Debnath, R. Sarkar, S. K. Nandi and Debasish Haldar*. Chem. Select, 2017, 2, 8146-8150. DOI: 10.1002/slct.201701577
- Supramolecular double helix from capped γ-peptide.S. K. Maity, S. Maity, P. Jana and Debasish Haldar*. Chem. Commun., 2012, 48 711-713. DOI: 10.1039/C1CC15585A
- A new peptide motif in the formation of supramolecular double helices. P. Jana, S. Maity, S. K. Maity and Debasish Haldar*. Chem. Commun., 2011, 47 2092-2094. DOI: 10.1039/C0CC04244G
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Peptide based therapeutics.
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Peptides have long been considered to hold great potential as therapeutic drugs. They provide promising drug scaffold for drug discovery from the angles of various physical, chemical and biological aspects. They can unlock a universe of protein targets and protein-protein interactions that are often considered as 'undruggable' using conventional methods. However, the shortcomings of peptides as pharmaceutical products such as typically short duration of action, lack of receptor subtype selectivity, lack of oral bioavailability have been long known. Due to proteases, opsonization and agglutination, free peptides are not systemically stable without modifications. Overcoming all these issues, we have recently developed two peptide based therapeutics.
- Potential Antileishmanial Activity of a Triazole based Hybrid Peptide Against Leishmania major, K. Maji, M. Abbasi, D. Podder, Rupak Datta* and Debasish Haldar*. ChemistrySelect, 2018, 3 (36), 10220-10225, DOI: 10.1002/slct.201802002
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Development of sensors for small molecules.
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With increasing pollution level, it is becoming very much urgent to detect those pollutants present in our environment. So detection of small molecules or ions by absorption or emission spectroscopy is currently a hot topic. In this field recently we are working to design and synthesize different molecule and ion sensors.
- On-line Ammonia Sensor and Invisible Security Ink by Fluorescent Zwitterionic Spirocyclic Meisenheimer Complex. T. Das, A. Pramanik and Debasish Haldar*. Scientific Reports, 2017, 7 40485. DOI: 10.1038/srep40485
- Sonication-Assisted Synthesis of Hydantoin Derivative-Decorated Graphene Oxide-Based Sensor for Guanine. Chemistry Select, 2017, 2 5832-5837. DOI: 10.1002/slct.201851218
- Hierarchical self-assembly of naphthalene bisimides to fluorescent microsphere and fluoride sensing. P. Jana, S. K. Maity, S. Bera, P. K. Ghorai and Debasish Haldar*. CrystEngComm. 2013, 15, 2512-2518. DOI: 10.1039/C3CE26850H.
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Development of smart materials.
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Recently we have applied some of our materials for different cutting edge applications in our daily lives. We are planning to design and synthesize more of this kind of materials.
- POSS-Appended Diphenylalanine: Self-Cleaning, Pollution-Protective, and Fire-Retardant Hybrid Molecular Material. K. Maji and Debasish Haldar*. ACS Omega. 2017, 2, 1938-1946. DOI: 10.1021/acsomega.7b00234.
- On-line Ammonia Sensor and Invisible Security Ink by Fluorescent Zwitterionic Spirocyclic Meisenheimer Complex. T. Das, A. Pramanik and Debasish Haldar*. Scientific Reports, 2017, 7 40485. DOI: 10.1038/srep40485
- A small molecule peptidomimetic of spider silk and web. K. Maji, R. Sarkar, S. Bera and Debasish Haldar*. Chem. Commun., 2014, 50 12749-12752. DOI: 10.1039/C4CC04475D
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Synthesis of non coded amino acids.
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Synthetic non-coded amino acids with well-defined stereochemical and functional properties have different exciting functional and structural diversity. The design and synthesis of new non-coded amino acid building blocks are of great demand due to their stability towards enzymatic degradation.
- Fabrication of egg shell like nanovesicles from thiocoumarin based e-amino ester: a potential carrier. M. Debnath, S. Sasmal and Debasish Haldar*. J. Mat. Chem B, 2017, 5, 5450-5457. DOI: 10.1039/C7TB00025A
- Packing-induced solid-state fluorescence and thermochromic behavior of peptidic luminophores. A. Pramanik and Debasish Haldar*. RSC Advances, 2017, 7, 389-395. DOI: 10.1039/C6RA24799G.
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Peptide based nano structure materials.
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Nanostructure materials are highly important for biomedical application such as drug delivery. Peptides based nanostructures are highly attractive due to their biocompatibility and chemical diversity. So that, we are trying to develope new well-defined peptide based nanostructure materials having some novel properties.
- Insights into self-assembling nanoporous peptide and in situ reducing agent. P. Jana, S. Maity and Debasish Haldar*. CrystEngComm, 2011, 13, 973-978.DOI: 10.1039/C0CE00143K
- Sonication-Assisted Synthesis of Hydantoin Derivative-Decorated Graphene Oxide-Based Sensor for Guanine. S. Sasmal and Dr. Debasish Haldar*. Chemistry Select, 2017, 2, 5832-5837. DOI: 10.1002/slct.201851218
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Nanoreactor.
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Nanoreactors are a form of chemical reactor that are particularly in the disciplines of nanotechnology and nanobiotechnology. Whole over the world, chemists have worked to understand how fundamental chemical principles change when systems are confined to spaces with nanoscale dimensions. In our lab we are also trying to form some paptide based nanoreactor to understand the same.
- Solvent Assisted Room Temperature Synthesis of Magnetically Retrievable and Reusable Dipeptide Stabilized Nanocrystals for Suzuki-Miyaura Cross-Coupling. R. Sarkar, S. Sasmal, D. Podder and Debasish Haldar*.
Macromolecular Symposia, 2016, 369, 67-73.
DOI: 10.1002/masy.201600061.
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Collaborators:
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Prof. Dr. David Díaz Díaz
Heisenberg Professor.
Universität Regensburg, Institut für Organische Chemie, Universitätsstr. 31, D-93053 Regensburg, Germany.
Email. david.diaz@chemie.uni-regensburg.de
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