Details of ID4111 (Autumn 2013)
| Level: 4 | Type: Theory | Credits: 3.0 |
| Course Code | Course Name | Instructor(s) |
|---|---|---|
| ID4111 | Bioinformatics | Anirban Banerjee, Shree Prakash Pandey |
| Syllabus |
|---|
| DNA AND AMINO ACID SEQUENCES: FEATURE EXTRACTION, ALIGNMENT AND INFERENCES
Exploration of biological features; exploration of quantitative characteristics; alignment algorithms (Needleman-Wunsch, Smith-Waterman, BLAST); algorithms for determination of higher order structure EVOLUTIONARY INFERENCE FROM SEQUENCE DATA: ESTIMATING RATES OF EVOLUTION Jukes and Cantor model; Kimura's two-parameter model; Tajima and Nei's method; BIOINFORMATICS APPROACHES TO OMICS ANALYSIS Exploration of trends in high-throughput data using Principal Component Analysis (PCA) and hierarchical clustering; differential gene expression using moderated t-tests and Receiver Operating Characteristic (ROC); Gene set (pathway) enrichment analysis; exploration of correlation gene networks METHODS OF SYSTEMS BIOLOGICAL INFERENCE |
| References |
|---|
| 1. Biological Sequence analysis by Durbin, Eddy, Krogh, Mitchison (Cambridge University Press, 1998)
2. Fundamentals of Molecular Evolution by Dan Graur and Wen-Hsiung Li (Sinauer, 2000, Second Edition) 3. Bioinformatics: Sequence and Genome Analysis by David W Mount (Cold Spring Laboratory Press 2004, Second Edition). |
Course Credit Options
| Sl. No. | Programme | Semester No | Course Choice |
|---|---|---|---|
| 1 | IP | 1 | Elective |
| 2 | IP | 3 | Elective |
| 3 | MS | 7 | Elective |
| 4 | RS | 1 | Elective |