Details of CH4201 (Spring 2013)
| Level: 4 | Type: Theory | Credits: 3.0 |
| Course Code | Course Name | Instructor(s) |
|---|---|---|
| CH4201 | Bio-Inorganic Chemistry | Arindam Mukherjee, R. N. Mukherjee, Sumit Khanra |
| Syllabus |
|---|
| Bioinorganic Chemistry of Iron: (a) Substrate Activation, Catechol Dioxygenases, Bio-Inspired Oxidation Catalysis; (b) Reaction Intermediates: Iron-Peroxo Intermediates, High-Valent Iron-Oxo Intermediates, The Road to Non-Heme Oxoferryls; (c) Oxygen and C-H Activation Chemistry of Methane Monooxygenase (MMO), the conversion of Methane to Methanol in Methanotrophic Bacteria, Mechanistic Studies on the Hydroxylation of Methane by Methane Monooxygenase; (d) Non-Heme Iron Analogues of Cytochrome P450. Synthetic Models for Non-Heme Carboxylate-Bridged Diiron Metalloproteins:? Strategies and Tactics, Hydrogenases and Nitrogenases: [Fe]-Hydrogenases. [NiFe]-Hydrogenases, Manganese Chemistry with the Relevance to Photosystem II (PS-II); Bioinspired Catalyses towards renewable alternative carbon-free energy
Electron Transfer: 1. Iron-Sulphur Proteins; 2. Blue Copper Proteins Dioxygen Binding: Nature of the Dioxygen-Metal Bond: Contributions to Reversible Dioxygen Binding; Superoxide and Peroxide Dismutases. Oxidases and Oxygenases: Mononuclear Non-Heme Enzymes, Binuclear Copper Enzymes, Trinuclear Copper Cluster Enzymes, The CuB-Heme Site in Cytochrome c Oxidase, intermediates: Substrate Activation, Dioxygen Activation Ion Transport: Introduction to ion transport, Ion channels, ATPase pumps Metals in medicine: introduction to structure of DNA and proteins, Intercalation in DNA, binding to guanine bases, alkylation of nitrogen in the bases, cisplatin- syntheses and mechanism of action, mustards in clinic and mechanism of action of mustards, anthracyclines in clinic and their mechanism of action, topoisomerase inhibition, protein kinase inhibition, combination therapy. Fundamentals of Biological macromolecules. Proteins, Nitrogenases and nitrogen fixation role of molybdenum., Nitrogen cycle, cofactors in nitrogenases, Cobalt in biology. Structure and function of vitamin B12 the first organometallic compound in biology. Molybdenum-cofactor enzymes viz. xanthine oxidase, Nitrate reductase, DMSOreductase Biological importance of nickel Urease: conversion of urea to ammonia. Noble prize for urease crystals, structure of urease, reaction mechanism Metal ion transport and storage - Ferritin - structure, mechanisms of iron entry, mineralization and exit, difference from common metalloenzymes. Metal toxicity: iron overload |
| References |
|---|
Course Credit Options
| Sl. No. | Programme | Semester No | Course Choice |
|---|---|---|---|
| 1 | IP | 2 | Elective |
| 2 | IP | 4 | Elective |
| 3 | MS | 8 | Core |
| 4 | RS | 1 | Elective |