Details of ID4210 (Spring 2013)
| Level: 4 | Type: Theory | Credits: 3.0 |
| Course Code | Course Name | Instructor(s) |
|---|---|---|
| ID4210 | Biological Physics | Rumi De |
| Syllabus |
|---|
| 1 Introduction what is life;
2 Basic facts about cells nuclear and cytoskeletal elements, biopolymer, membrane, molecular motors, DNA, Proteins and other major large and small molecules; 3 Forces in the living world chemical forces, coulomb forces, Van der Waals interaction, electrostatic, hydrogen bonding, hydrophobic effect, entropic forces, depletion forces; 4 Essential thermodynamics and statistical physics temperature, free energy, entropy, probability distribution, Boltzmann factor; 5. Random walks in biology. 6. Physics of Biopolymers - what are polymers, common polymers, biopolymers, polymerization, polymer models- Freely joint chain, Self avoiding random walk, Worm-like chain, persistence length, conformational entropy and entropic force, scaling laws; 7. Cytoskeleton dynamics simple models of cytoskeletal filament (actin, microtubule) polymerization, dynamic of molecular motors; 8. Brownian motion and diffusion in biology active and passive transport, Fick's law, diffusion equation, modeling cell signaling problem, membrane transport, sedimentation; 9. Biomechanics elasticity theory, stress, strain and constitutive relations, extension and torsion, bending of beam, buckling, examples from biology; cell adhesion; 10. Physics of Interface and Membrane; 11. Reaction Kinetics; rate equations and dynamics in the cell. |
| References |
|---|
| Biological Physics: Energy, Information, Life; Philip Nelson, W. H. Freeman Co.
2. Alberts et al., Molecular Biology of the Cell, 4th edition, Garland Science. 3. Intermolecular and surface forces, Jacob N. Israelachvili., Academic Press 4. Random walks in biology by H. Berg 5. Theory of elasticity; L. Landau and E. Lifshitz 6. Mechanics of the Cell" By David Boal, Cambridge University Press 7. An Introduction to Biomechanics: Solids and Fluids, Analysis and Design, J. D. Humphrey and S. DeLange, Springer Science, Berlin. 8. Statistical Thermodynamics of Surfaces, Interfaces, and membranes; S. A. Safran 9. The Theory of Polymer Dynamic; M. Doi and S. F. Edwards 10. Introduction to Polymer Physics, M . Doi 11. Scaling Concept in Polymer Physics; P. G. De Gennes 12. Principles of Condensed Matter Physics; P. M. Chaikin and T. C. Lubensky 13. Physical biology of the cell; Robert B. Phillips, Jan Kondev, Julie Theriot 14. Mechanics of Motor Proteins and the Cytoskeleton; J. Howard 15. Mathemetical Bilogy; J. D. Murray 16. What is Life? By E. Schroedinger, Canto Book Series, Cambridge University Press. 17. Reading from the literature |
Course Credit Options
| Sl. No. | Programme | Semester No | Course Choice |
|---|---|---|---|
| 1 | IP | 2 | Elective |
| 2 | IP | 4 | Elective |
| 3 | MS | 8 | Elective |
| 4 | RS | 1 | Elective |