Details of CH3102 (Autumn 2020)
| Level: 3 | Type: Theory | Credits: 4.0 |
| Course Code | Course Name | Instructor(s) |
|---|---|---|
| CH3102 | Organic Chemistry I | Dibyendu Das, Pradip Kumar Tarafdar |
| Syllabus |
|---|
| Reactions of Carbonyl Compounds (8 Lectures)
Addition-Elimination Mechanism, hydration of carbonyls, hemi-acetal (anomeric effect of Dmethylglucopyranoside), acetal, hemiketal (D-fructose cyclic structure), ketal formation (stability of cyclic ketals, anomeric effect); Reactions involving Nucleophilic Carbon Intermediates (8 Lectures) (a) Aldol reaction, (b) Mannich reaction, (c) Crossed aldol, (d) Aldol condensation, (e) Nitro aldol; (f) Strecker reaction (g) Cannizaro reactions: Intermolecular & intramolecular version (concept of hydride delivery from organic molecules) (h) Perkin reaction, (i) Kneoevenagel condensation, (j) Claisen reaction(k) Dickmann condensation Oxidations (8 Lectures) (a) Ozonolysis (b) OsO4 and KMnO4 oxidation of olefins (dihydroxylation) (c) SeO2-oxidation of olefins; Oxidations using Cr(VI)-complexes: (a) Jones oxidation (b) PDC oxidation (c) PCC oxidation (c) Dauben oxidation; Activated DMSO/DMS Complexes (a) Swern Oxidation (b) Corey-Kim oxidation; Hypervalent iodine reagents: (a) IBX Oxidation (b) Dess-Martin Periodinane (DMP) (c) PIDA oxidation Reductions (8 Lectures) Reduction of carbonyls using metal hydrides (a) NaBH4 (b) NaBH3CN (c) LiBH4 (d) LiAlH4 (e) BH3 or B2H6 (f) DiBAL-H (g) L-selectride; Ketone reduction under (a) Clemension reduction, (b) Wolf-Kishner reduction (c) Mozingo reduction; Catalytic hydrogenation and imide reductions of C-C double and triple bonds; Reduction using dissolving metals: (a) Birch reduction, (b) Acyloin condensation, (c) Bouveault-Blanc reduction; Reductions under transfer hydrogenation; Meerwein-Ponndorf-Verley (MPV) reduction (& Oppenuer oxidation) Rearrangements (8 Lectures) Electrophilic Rearrangements: (a) Wagner-Meerwein, (b) Pinacol-pinacolone, (c) Demzanov reaction (d) Dienone-phenol rearrangement (e) Beckmann rearrangement, (f) Hofmann degradation, (g) Lossen rearrangement, (h) Curtius rearrangement, (i) Wolff rearrangement, (j) Schmidt reaction, (k) Baeyer-Villiger oxidation; Nucleophilic Rearrangements:(a) Benzil-Benzilic acid rearrangement (b) Favorski rearrangement etc |
| References |
|---|
| References
1. Guidebook to Mechanism in Organic Chemistry, by Peter Sykes, 6$^th $ Edition. 2. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, by Jerry March, 5$^th $ Edition. 3. Organic Chemistry, by J. Clayden, N. Greeves, S. Warren and P. Wothers. 4. Organic Chemistry, by I. L. Finar, Longmans, vol. 1 & 2, 4$^th Edition |
Course Credit Options
| Sl. No. | Programme | Semester No | Course Choice |
|---|---|---|---|
| 1 | IP | 1 | Not Allowed |
| 2 | IP | 3 | Not Allowed |
| 3 | IP | 5 | Not Allowed |
| 4 | MR | 1 | Not Allowed |
| 5 | MR | 3 | Not Allowed |
| 6 | MS | 5 | Core |
| 7 | MS | 7 | Not Allowed |
| 8 | MS | 9 | Not Allowed |
| 9 | RS | 1 | Not Allowed |
| 10 | RS | 2 | Not Allowed |