Details of LS4108 (Autumn 2020)
| Level: 4 | Type: Theory | Credits: 4.0 |
| Course Code | Course Name | Instructor(s) |
|---|---|---|
| LS4108 | Protein Structure, Function and Engineering | Rahul Das, Supratim Datta |
| Preamble |
|---|
| This course designed to provide undergraduate students with an introduction to how nature transforms and manipulate biologically relevant molecules. The course will introduce methods and strategies commonly used in protein structure and engineering. At the end of the course, students should be able to understand and explain the role of protein structure and dynamics and how to engineer proteins. The student will know the differences between rational design and directed evolution and have general knowledge about miscellaneous topics such as the analysis of secondary, tertiary and quaternary structure, as well as of screening methods used for the selection of novel protein variants with improved properties.
Case studies will be used to illustrate the concepts presented. |
| Syllabus |
|---|
| Overview of protein structure and dynamics
Modular system of proteins Eg. Kinases and regulation of kinases; Protein structure, dynamics and drug interactions Recombinant DNA technology Protein engineering techniques Directed evolution methods and high throughput screening Circular permutation, computational protein design, antibody engineering Synthetic biology- Introduction, and applications in bioengineering |
| References |
|---|
| References and handouts will be provided in class. |
Course Credit Options
| Sl. No. | Programme | Semester No | Course Choice |
|---|---|---|---|
| 1 | IP | 1 | Elective |
| 2 | IP | 3 | Elective |
| 3 | IP | 5 | Elective |
| 4 | MR | 1 | Not Allowed |
| 5 | MR | 3 | Not Allowed |
| 6 | MS | 5 | Not Allowed |
| 7 | MS | 7 | Elective |
| 8 | MS | 9 | Elective |
| 9 | RS | 1 | Elective |
| 10 | RS | 2 | Elective |