LS4109 : Epigenetics (Autumn 2020) | Academic Portal of IISER Kolkata

Details of LS4109 (Autumn 2020)

Level: 4

Type: Theory

Credits: 4.0

Course Code	Course Name	Instructor(s)
LS4109	Epigenetics	Sudhamalla Babu

Syllabus
Brief history of epigenetics, Fundamentals of regulation of gene expression, histone code and chromatin organization-Nucleosome solenoid model. Histone modifications and Histone variants, and their role in gene regulation. Mechanisms of histone modifications: Role of Polycomb Group proteins and Trithorax group proteins. DNA methylation and its effect on gene regulation, Mechanisms of DNA methylation. Role of regulatory elements such as boundary elements and insulators and the mechanism through which they regulate development, differentiation and complex diseases. Factors influencing epigenetic modifications: Diet, Metabolism, stress, Aging, memory etc. Evolutionary significance of epigenetic modifications, Transgenerational inheritance. Epigenetics and human diseases: cancer epigenetics, autoimmune disorders, metabolic diseases, brain disorders, imprinting disorders.

Syllabus

Brief history of epigenetics, Fundamentals of regulation of gene expression, histone code and chromatin organization-Nucleosome solenoid model.
Histone modifications and Histone variants, and their role in gene regulation.
Mechanisms of histone modifications: Role of Polycomb Group proteins and Trithorax group proteins.
DNA methylation and its effect on gene regulation, Mechanisms of DNA methylation.
Role of regulatory elements such as boundary elements and insulators and the mechanism through which they regulate development, differentiation and complex diseases.
Factors influencing epigenetic modifications: Diet, Metabolism, stress, Aging, memory etc.
Evolutionary significance of epigenetic modifications, Transgenerational inheritance.
Epigenetics and human diseases: cancer epigenetics, autoimmune disorders, metabolic diseases, brain disorders, imprinting disorders.

References
Handbook of Epigenetics: The New Molecular and Medical Genetics/Edited by Trygve O. Tollefsbol, Edition 2. Epigenetics/Edited by C. David Allis, Marie-Laure Caparros, Thomas Jenuwein, Danny Reinberg; Associate Editor, Monica Lachner, Edition 2. Histone variants ancient wrap artists of the epigenome. Talbert P. B. and Henikoff, S. Nat. Rev. Mol. Cell Biol., 2010 doi:10.1038/nrm2861. Divide and (epigenetic) rule: Chromatin domains as functional and structural units of genomes. Mishra RK and Galande S. Journal of Indian Academy of Sciences, Platinum Jubilee issue, 2009, pp 211-224. The mammalian epigenome. Berstein et al., Cell 2007, 128: 669-681. Linking DNA methylation and histone modification: patterns and paradigms. Cedar H, Bergman Y. Nat Rev Genet. 2009, 10(5):295-304. Boundaries. Boundaries...Boundaries??? Lunyak VV. Curr Opin Cell Biol. 2008, 20(3):281-7. Transgenerational Epigenetic Inheritance: Myths and Mechanisms. Heard E and Martienssen R, Cell 2014, 157(1):95109.

References

Handbook of Epigenetics: The New Molecular and Medical Genetics/Edited by Trygve O. Tollefsbol, Edition 2.
Epigenetics/Edited by C. David Allis, Marie-Laure Caparros, Thomas Jenuwein, Danny Reinberg; Associate Editor, Monica Lachner, Edition 2.
Histone variants ancient wrap artists of the epigenome. Talbert P. B. and Henikoff, S. Nat. Rev. Mol. Cell Biol., 2010 doi:10.1038/nrm2861.
Divide and (epigenetic) rule: Chromatin domains as functional and structural units of genomes. Mishra RK and Galande S. Journal of Indian Academy of Sciences, Platinum Jubilee issue, 2009, pp 211-224.
The mammalian epigenome. Berstein et al., Cell 2007, 128: 669-681.
Linking DNA methylation and histone modification: patterns and paradigms. Cedar H, Bergman Y. Nat Rev Genet. 2009, 10(5):295-304.
Boundaries. Boundaries...Boundaries??? Lunyak VV. Curr Opin Cell Biol. 2008, 20(3):281-7.
Transgenerational Epigenetic Inheritance: Myths and Mechanisms. Heard E and Martienssen R, Cell 2014, 157(1):95109.

Sl. No.	Programme	Semester No	Course Choice
1	IP	1	Elective
2	IP	3	Elective
3	IP	5	Not Allowed
4	MR	1	Not Allowed
5	MR	3	Not Allowed
6	MS	5	Not Allowed
7	MS	7	Elective
8	MS	9	Not Allowed
9	RS	1	Elective
10	RS	2	Elective