Details of LS4202 (Spring 2022)

Level: 4 Type: Theory Credits: 4.0

Course CodeCourse NameInstructor(s)
LS4202 Biophysics II Dipjyoti Das,
Neelanjana Sengupta

Syllabus
Concepts:
Essential mathematical tools; Concepts of heat, work, entropy, free energy minimization; Boltzmann Distribution
Revision of random walk, Persistence length
Fluctuations, Diffusion and Dissipation.
Non-bonded interactions, Bjerrum length, Debye screening, Poisson-Boltzmann Equation;
Nonequilibrium distribution of ions in cells: Donnan Equilibrium, Nernst Potential;
Macroscopic manifestation: Reynolds Number, Naviers Stokes Equation;
Stochastic processes.



Systems/processes from different scales:
Forces and energetics of Protein structure and folding; Allosteric interactions;
Membrane structure and mechanics;
Forces generated by actin polymerization, molecular motors;
Mechanisms of origin and propagation of action potential;
Mechanism of bacterial motility, understanding blood flow through capillaries;
Pattern formation and oscillations in biosystems.

References
Biological Physics (updated edition, 2004) Philip C. Nelson.
Biophysics. Roland Glasser. Springer (2001)
Random walks in biology. H. Berg. Princeton University Press (1993)
Molecular Biology of the cell. Alberts et al. Garland Science (2007)
Physical Biology of the cell. Rob Phillips, Jane Kondev, Julie Theriot. Garland Science (2008)

Course Credit Options

Sl. No.ProgrammeSemester NoCourse Choice
1 IP 2 Elective
2 IP 4 Elective
3 IP 6 Not Allowed
4 MP 2 Not Allowed
5 MP 4 Not Allowed
6 MR 2 Not Allowed
7 MR 4 Not Allowed
8 MS 10 Elective
9 MS 4 Not Allowed
10 MS 6 Not Allowed
11 MS 8 Elective
12 RS 1 Elective
13 RS 2 Elective