Details of LS4203 (Spring 2023)
| Level: 4 | Type: Theory | Credits: 4.0 |
| Course Code | Course Name | Instructor(s) |
|---|---|---|
| LS4203 | Gene Regulation | Arnab Gupta, Rahul Das, Sumit Sen Santara |
| Syllabus |
|---|
| Basic concepts in regulation of gene expression: Components of prokaryotic gene regulation Constitutive, Inducible, and Repressible Gene Expression; Fine regulation (operon concept: lac, Trp and lambda operons as models), Translational and post translational regulatory mechanism.
Eukaryotic transcriptional control (RNA polymerases, transcription factors), post-transcriptional processes (splicing, mRNA export, localization, translation, decay, siRNA, miRNA), post-translational modifications as means of regulation of gene function. Chromatin remodelling and Epigenetic regulation. Regulation of viral gene expression. Concepts in cellular communication: Response to stimuli as a determinant of gene regulation, ligand-receptor interactions, calculation of dissociation constants and Scatchard analysis, nature and variety of signal transduction pathways. Regulatory networks and allosteric regulation of cellular signaling, Regulation of GPCRs. Nutrient-mediated regulation of gene expression, Cellular response in stress, Nutrient distribution in the cell, mTORC mediated regulation of amino acids and other micronutrients, lysosomes in nutrient recycling and translation regulation, lysosomal positioning as a read-out of cellular stress status, mTOR and cancer, Superoxide dismutase as a scavenger of oxidative stress. |
| References |
|---|
Course Credit Options
| Sl. No. | Programme | Semester No | Course Choice |
|---|---|---|---|
| 1 | IP | 2 | Elective |
| 2 | IP | 4 | Elective |
| 3 | IP | 6 | Not Allowed |
| 4 | MP | 2 | Not Allowed |
| 5 | MP | 4 | Not Allowed |
| 6 | MR | 2 | Not Allowed |
| 7 | MR | 4 | Not Allowed |
| 8 | MS | 10 | Elective |
| 9 | MS | 4 | Not Allowed |
| 10 | MS | 6 | Not Allowed |
| 11 | MS | 8 | Elective |
| 12 | RS | 1 | Elective |
| 13 | RS | 2 | Elective |