Details of CH5103 (Autumn 2025)
| Level: 5 | Type: Theory | Credits: 4.0 |
| Course Code | Course Name | Instructor(s) |
|---|---|---|
| CH5103 | Supramolecular Chemistry and Applications | Debasish Haldar, Dibyendu Das |
| Syllabus |
|---|
| Basic concepts and principles, including the history and evolution of supramolecular chemistry and the significance of molecular recognition.
Non-covalent interactions: hydrogen bonds, van der Waals forces, halogen bonding, n-n interactions, aromatic-aromatic interactions, and sulfur-aromatic interactions. Macrocyclic and mechanically interlocked molecules: synthesis and properties of crown ethers, cryptands, calixarenes, cucurbiturils, catenanes, and rotaxanes; applications in molecular machines and devices. Principles of self-assembly in chemical and biological systems, including the design and synthesis of self-assembling systems with applications in nanotechnology and materials science. Biological supramolecular systems, including the role of supramolecular interactions in DNA, proteins, and membranes, as well as the design of supramolecular systems for drug delivery, biosensing, and nanobiotechnology applications. Artificial receptors and host-guest chemistry: cation-binding hosts, anion-binding hosts, neutral guest hosts, transport processes, and chemical sensing applications. Thermodynamic principles governing supramolecular interactions: examination of the energetic contributions that drive non-covalent interactions, including enthalpic and entropic factors. Mechanisms of catalysis in supramolecular systems, including insights into the design of catalytic sites within supramolecular frameworks. Principles behind synthetic enzyme mimics, the role of non-covalent interactions in enhancing catalytic efficiency, and the application of host-guest systems in selective transformations. Supramolecular polymers, dynamic and reversible nature of supramolecular polymerization processes, including the mechanisms driving their formation. Physicochemical properties of these materials, such as stimuli-responsive behavior, self-healing, and adaptive properties. Metal-organic frameworks (MOFs) and covalent organic frameworks (COFs): design, synthesis, characterization, applications in gas storage, separation, and catalysis, and dynamic behavior and functionalization. Advanced topics: dynamic combinatorial library, self-replicating and evolving systems, Non-equilibrium self-assembly and systems chemistry: principles of dissipative self-assembly, chemical reaction networks, and applications in designing responsive and adaptive systems.Recent advancements and future directions in the field. |
| References |
|---|
| 1. Supramolecular Chemistry by J. W. Steed & J. L. Atwood, 2ndEdn John Wiley, 2009.
2. Crystal Engineering. The Design of Organic Solids by G.R. Desiraju, Elsevier, 1989. 3. J. M. Lehn, Supramolecular Chemistry, VCH, Weinheim, 1995 |
Course Credit Options
| Sl. No. | Programme | Semester No | Course Choice |
|---|---|---|---|
| 1 | IP | 1 | Not Allowed |
| 2 | IP | 3 | Not Allowed |
| 3 | MP | 1 | Not Allowed |
| 4 | MP | 3 | Elective |
| 5 | MR | 1 | Elective |
| 6 | MR | 3 | Elective |
| 7 | MS | 3 | Not Allowed |
| 8 | MS | 5 | Not Allowed |
| 9 | MS | 7 | Not Allowed |
| 10 | MS | 9 | Elective |
| 11 | RS | 1 | Elective |
| 12 | RS | 2 | Elective |