Details of LS4202 (Spring 2025)
| Level: 4 | Type: Theory | Credits: 4.0 |
| Course Code | Course Name | Instructor(s) |
|---|---|---|
| LS4202 | Biophysics II | Bidisha Sinha, Dipjyoti Das |
| Preamble |
|---|
| Students need to have a working knowledge of programming in
MATLAB/Python. Basic knowledge of probability distribution, elementary algebra and calculus (such as differentiation and integration) is expected. |
| Syllabus |
|---|
| Biological Electricity: Non-bonded interactions, Bjerrum length, Debye screening, Poisson-Boltzmann Equation; Nonequilibrium distribution of ions in cells: Donnan
Equilibrium, Nernst Potential; Mechanisms of origin and propagation of action potential; Hodgkin-Huxley Model. Chemical and Mechanical Equilibrium and Cellular Mechanics: Forces and energetics of Protein structure and folding; Allosteric interactions; Membrane structure and mechanics; Forces generated by actin polymerization, molecular motors; Cytoskeleton mechanics; Measurement of cellular dynamics; Cell motility Biological Patterns: Pattern formation and oscillations; Lotka-Volterra systems; French flag model, Notch delta signaling; Stochastic processes: Revision of random walk, Fluctuations, Diffusion and Dissipation, generalisation to drift- diffusion equation and its application in pattern formation Polymer model using random walk, persistence length, Biochemical reaction-kinetics: Law of mass action, enzyme kinetics, cooperativity, Concept of gene expression noise; Genetic circuits with feedbacks |
| References |
|---|
| Biological Physics (updated edition, 2004) Philip C. Nelson.
Biophysics. Roland Glasser. Springer (2001) Random walks in biology. H. Berg. Princeton University Press (1993) Molecular Biology of the cell. Alberts et al. Garland Science (2007) Physical Biology of the cell. Rob Phillips, Jane Kondev, Julie Theriot. Garland Science (2008) |
Course Credit Options
| Sl. No. | Programme | Semester No | Course Choice |
|---|---|---|---|
| 1 | IP | 2 | Elective |
| 2 | IP | 4 | Elective |
| 3 | IP | 6 | Not Allowed |
| 4 | MP | 2 | Not Allowed |
| 5 | MP | 4 | Not Allowed |
| 6 | MR | 2 | Not Allowed |
| 7 | MR | 4 | Not Allowed |
| 8 | MS | 10 | Elective |
| 9 | MS | 4 | Not Allowed |
| 10 | MS | 6 | Not Allowed |
| 11 | MS | 8 | Elective |
| 12 | RS | 1 | Elective |
| 13 | RS | 2 | Elective |