Details of LS3101 (Autumn 2026)
| Level: 3 | Type: Theory | Credits: 4.0 |
| Course Code | Course Name | Instructor(s) |
|---|---|---|
| LS3101 | Immunology | Amirul Islam Mallick, Sumit Sen Santara |
| Preamble |
|---|
| This course is designed to provide both fundamental and translational knowledge of immunobiology. The first part of the course offers a strong foundation in immunology, focusing on the cellular and molecular aspects of immune function. The second part emphasizes the critical interplay between innate and adaptive immunity, exploring how these two systems work together to protect the body from pathogens. The course also covers essential immunological techniques used in research and clinical applications, highlighting how principles of infection biology, immunology, and biomedicine can be applied to solve specific problems. |
| Syllabus |
|---|
| An Introduction to Immunology: Cells and molecules involved in innate and adaptive immunity, Antigens, Antigenicity and immunogenicity, B and T cell epitopes, Structure and function of antibody molecules, Generation of antibody diversity, Monoclonal antibodies, Antigen-antibody interactions, MHC molecules, Evolution of immune system
Innate Immunity: Recognition of antigen: Antigen recognition by B and T cell receptor, Generation of Lymphocytes antigen receptor] , Antigen presentation to T lymphocytes The Development and Survival of Lymphocytes: Clonal selection theory, Generation of lymphocytes in bone marrow and thymus, Negative and positive selection of lymphocytes, DNA rearrangement mechanism of B and T-cell receptors, Maturation of lymphocytes in peripheral lymphoid tissues The Adaptive Immune Response: T cell mediated immunity, the humoral immune response, Dynamics of adaptive immunity The Mucosal Immune System: Mucosa-associated lymphoid tissue (MALT, NALT, GALT), lymphocyte repertoire at MALT and GALT, role of secretory IgA, gut microflora and tolerance, Enteric pathogens and gut immunity. The Immune System in Health and Diseases: Failure of host defense mechanism, Acquired immunodeficiency, Allergy and hypersensitivity, Autoimmunity and transplantation, Manipulation of the immune system. Tools and Techniques used in Immunology: Strength of antigen-antibody interaction (affinity vs avidity), Precipitation assay, agglutination assay, ELISA, RIA, immunofluorescence and flow cytometry, Immunoblotting. |
| References |
|---|
| References
1. Kenneth Murphy, Paul Travers, Mark Walport, Janeways Immunobiology, 7th Edition, Garland Science 2. Thomas J. Kindt, Richard A. Goldsby, Barbara A Osborne, Kuby Immunology, Edition 6, W.H. Freeman 3. Peter J. Delves, Roitt's Essential Immunology , Edition 11, Blackwell (2011). |
Course Credit Options
| Sl. No. | Programme | Semester No | Course Choice |
|---|---|---|---|
| 1 | IP | 1 | Elective |
| 2 | IP | 3 | Elective |
| 3 | MP | 1 | Elective |
| 4 | MP | 1 | Not Allowed |
| 5 | MP | 3 | Not Allowed |
| 6 | MR | 1 | Elective |
| 7 | MR | 3 | Elective |
| 8 | MS | 3 | Not Allowed |
| 9 | MS ( Biological Sciences ) | 5 | Core |
| 10 | MS | 7 | Elective |
| 11 | MS | 9 | Elective |
| 12 | RS | 1 | Elective |
| 13 | RS | 2 | Elective |