Details of CH4201 (Spring 2026)
| Level: 4 | Type: Theory | Credits: 4.0 |
| Course Code | Course Name | Instructor(s) |
|---|---|---|
| CH4201 | Advanced Organic Chemistry II | Alakesh Bisai, Sureshkumar Devarajulu |
| Preamble |
|---|
| The photochemistry and electrochemistry are considered to be sustainable processes, as they
avoid hazardous reagents, or byproducts in the process. This course introduces the student in the field of the Photoredox Processes (where light is used to alter the redox properties of compounds then accelerating chemical reactions by electron transfer between a photocatalyst and a substrate). The basic principles of Electrocatalysis will be discussed along with its applications in Organic Synthesis. After successfully completing the course, the students will be able to predict the biosynthesis of a given natural product depending on its structural characteristics. |
| Syllabus |
|---|
| Photoredox Processes and Applications in Organic Synthesis (10 Lectures)
Oxidative and Reductive Quenching Cycles of a Photoredox Catalyst; EDA Complexes and Exciplexes; Net Oxidative and Reductive Transformations, Net Redox Neutral Transformations; Organic Photoredox catalysis (Acridiniums, Fluorescein, Rhodamines, Perylenes, Riboflavin etc.); Merging Photoredox with Asymmetric Catalysis Electrocatalysis and Applications in Organic Synthesis (7 Lectures) Anodic oxidation; Main group compounds as mediators; Activation of alkenes with halogens; a-Functionalization of nitriles and carbonyls; HAT Processes; Phthalimido N-oxyl Radicals (PINO); Quinuclidine Radical Cations; Oxidation of unactivated C(sp3)H bonds; Oxidation of Electron-rich Species; Transition metal complex as mediators; Cathodic reduction; Cross- Electrophile Couplings [C(sp2)C(sp2); C(sp2)C(sp3) etc.] Organic Photochemistry (7 Lectures): Energy and electronic spin states, Spectroscopic transitions, photophysical processes, Jablonski Diagram, fluorescence and phosphorescence, energy transfer and electron transfer, and properties of excited states, Photochemistry of Alkenes and Carbonyl Compounds (Norrish Type I and II), and aromatic compounds. Electron-Transfer Reactions (3 Lectures): Theoretical basis, Examples of photo-induced and chemically-induced electron transfer reactions (PET and CET). Pericyclic Reactions (10 Lectures): Conservation of orbital symmetry, and Woodward and Hoffmann rules. Electrocyclizations, Electrocyclic Ring Opening, Cycloaddition Reactions (Sigmatropic Shifts, Sigmatropic Rearrangements, and Cheletropic reactions. Orbital overlap effects in chemical processes: FMO and PMO approaches). |
| References |
|---|
| References
1. Organic Synthesis, 3rd Ed., by M. B. Smith, McGraw Hill Higher Education, (2010). 2. Organic Synthesis: The Disconnection Approach, 2nd Ed. by S. Warren and P. Wyatt, John Wiley and Sons, (2008). 3. Organic Chemistry, 2nd Ed. by J. Clayden, N. Greeves and S. Warren, Oxford University Press, (2012). |
Course Credit Options
| Sl. No. | Programme | Semester No | Course Choice |
|---|---|---|---|
| 1 | IP | 2 | Not Allowed |
| 2 | IP | 4 | Not Allowed |
| 3 | MP ( Chemical Sciences ) | 2 | Core |
| 4 | MP | 4 | Not Allowed |
| 5 | MR | 2 | Not Allowed |
| 6 | MR | 4 | Not Allowed |
| 7 | MS | 10 | Not Allowed |
| 8 | MS | 4 | Not Allowed |
| 9 | MS | 6 | Not Allowed |
| 10 | MS | 8 | Elective |
| 11 | RS | 1 | Elective |
| 12 | RS | 2 | Elective |