"The joy of discovery is certainly the liveliest that the mind of man can ever feel"

- Claude Bernard -

As Principal Investigator

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Pandey R., Chakrabarty K., Bhattacharjee A, Gupta A., (2026) Balancing Copper: From Redox Biology to Disease and Therapy. Redox Biochemistry and Chemistry.

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Chatterjee S. K., Kar S., Nikte S., Dash T., Ghosh T., Paul M., Maji S., Sengupta D., Sinha B., Gupta A., (2025). Non-canonical regulation of the plasma membrane copper transporter CTR1 through modulation of membrane mechanical properties. Molecular Biology of the Cell.

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Pandey, R., Roy, A.N., Sarkar, S., Rohman, R., Chakraborty, K., Bargakshatriya, R., Pandey, S., Pruthwiraj, Bhattacharya, D., Kumar, S., Maji, S., Pezacki, A.T., Pramanik, S.K., Chang, C.J., Bhattacharjee, A., Sengupta, N., Das, A., & Gupta A., (2025). Repurposing melatonin's therapeutic potential in Wilson disease: Addressing copper overload and redox imbalance. Redox Biology.

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Abbas Q, Petrova ES, Tsymbalenko NV, Al Farrukh M, Magazenkova DN, Polishchuk EV, Petruzzelli R, Derkach KV, Kolos EA, Klyueva NN, Skvortsov AN, Di Sole F, Shpakov AO, Denisenko AD, Korzhevskii DE, Gupta A, Polishchuk RS, Puchkova LV, Ilyechova EY, (2025). High-Calorie Diet Accelerates the Liver Tissue Degeneration and Induces Subcutaneous White-to-Brown Fat Conversion in Mice with a Single-Allele Atp7b Mutation. J Nutr.

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Jose S.M., Maji S., Paul M., Gupta A.M., & Gupta A., (2025). Conserved inter-domain interactions drive trans-Golgi network localisation and trafficking of homologous copper-ATPases. J Cell Science.

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Mondal A., Dey S., Paul S., Gupta A., De P., (2025). Visible Light-Triggered Precision SO2 Release from Polymeric Nanomedicine for Cancer Therapy. Small.

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Ranjan A.d., Bhowmick S., Gupta A., Mallick A.I., Banerjee A., (2024). Biologically Active Micropatterns of Biomolecules and Living Matter Using Microbubble Lithography. Small.

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Paul, R., Chakrabarty, A., Samanta, S., Dey, S., Pandey, R., Maji, S., Pezacki, A. T., Chang, C. J., Datta, R., Gupta, A. (2024). Leishmania major-induced alteration of host cellular and systemic copper homeostasis drives the fate of infection. Commun Biol.

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Ruturaj, Mishra, M., Saha, S., Maji, S., Rodriguez-Boulan, E., Schreiner, R., Gupta, A. (2023). Regulation of apico-basolateral trafficking polarity of homologous Copper-ATPases ATP7A and ATP7B. J Cell Sci.

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Maji, S., Pirozzi, M., Ruturaj, Pandey, R., Ghosh, T., Das, S., Gupta, A. (2023). Copper-independent lysosomal localization of the Wilson disease protein ATP7B. Traffic.

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Chakraborty, K., Das, S., Pal, A., Maji, S., Rai, B., Gupta, A., Bhattacharjee, A. (2023). Wilson disease causing mutations in the carboxyl terminus of ATP7B regulates its localization and golgi exit selectively in the unpolarized cells. Metallomics.

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Mondal, B., Padhy, A., Maji, S., Gupta, A., & Sen Gupta, S. (2023). Dual stimuli-responsive cross-linked nanoassemblies from an amphiphilic mannose-6-phosphate based tri-block copolymer for lysosomal membrane permeabilization. Biomaterials Science.

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Kar, J., Kar, S., Gupta, A., & Jana, S. S. (2023). Assembly and disassembly dynamics of nonmuscle myosin II control endosomal fission. Cell Reports.

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Das, S., Mohammed, A., Mandal, T., Maji, S., Verma, J., Ruturaj, & Gupta, A. (2022). Polarized trafficking and copper transport activity of ATP7B: A mutational approach to establish genotype–phenotype correlation in Wilson disease. Human Mutations.

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Chakraborty, K., Kar, S., Rai, B., Bhagat, R., Naskar, N., Seth, P., Gupta, A., & Bhattacharjee, A. (2022). Copper dependent ERK1/2 phosphorylation is essential for the viability of neurons and not glia. Metallomics.

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Kar, S., Sen, S., Maji, S., Saraf, D., Ruturaj, Paul, R., Dutt, S., Mondal, B., Rodriguez-Boulan, E., Schreiner, R., Sengupta, D., & Gupta, A. (2022). Copper(II) import and reduction are dependent on his-met clusters in the extracellular amino terminus of human copper transporter-1. Journal of Biological Chemistry.

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Paul, R., Banerjee, S., Sen, S., Dubey, P., Maji, S., Bachhawat, A., Datta, R. and Gupta, A. (2022). A novel leishmanial copper P-type ATPase plays a vital role in parasite infection and intracellular survival. Journal of Biological Chemistry.

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Chatterjee, R., Bhattacharya, I., Roy, S., Purkait, K., Koley, T. S., Gupta, A., & Mukherjee, A. (2021). Synthesis, characterization, and cytotoxicity of morpholine-containing ruthenium(ii) p-cymene complexes. Inorganic Chemistry.

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Das S, Maji S, Ruturaj, Bhattacharya I, Saha T, Naskar N, Gupta A. (2020). Retromer retrieves the Wilson Disease protein ATP7B from endolysosomes in a copper-dependent mode. J Cell Science.

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Mandal T, Kar S, Maji S, Sen S, Gupta A (2021). Structural and Functional Diversity Among the Members of CTR, the Membrane Copper Transporter Family. J Membr Biol.

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Maji, M., Acharya, S., Maji, S., Purkait, K., Gupta, A., & Mukherjee, A. (2020). Differences in Stability, Cytotoxicity, and Mechanism of Action of Ru(II) and Pt(II) Complexes of a Bidentate N,O Donor Ligand. Inorganic Chemistry.

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Maji M, Karmakar S, Ruturaj, Gupta A, Mukherjee A. Oxamusplatin: a cytotoxic Pt(ii) complex of a nitrogen mustard with resistance to thiol based sequestration displays enhanced selectivity towards cancer. Dalton Trans.

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Purkait K, Ruturaj, Mukherjee A, Gupta A. ATP7B Binds Ruthenium(II) p-Cymene Half-Sandwich Complexes: Role of Steric Hindrance and Ru-I Coordination in Rescuing the Sequestration. Inorganic Chemistry.

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Acharya S, Maji M, Ruturaj, Purkait K, Gupta A, Mukherjee A. Synthesis, Structure, Stability, and Inhibition of Tubulin Polymerization by RuII-p-Cymene Complexes of Trimethoxyaniline-Based Schiff Bases. Inorganic Chemistry.

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Arnab Gupta, Santanu Das, Kunal Ray. A glimpse in the regulation of the Wilson disease protein, ATP7B, sheds light on complexity of mammalian apical trafficking pathways. Metallomics.

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Arnab Gupta, Michael J. Schell, Ashima Bhattacharjee, Svetlana Lutsenko, Ann L. Hubbard. Myosin Vb mediates copper export in polarized hepatocytes. Journal of Cell Sciences.

From Postdoctoral & Doctoral tenure

  1. Lita Braiterman, Arnab Gupta, Raghothama Chaerkady, Robert N. Cole and Ann Hubbard. Communication between the N- and C-termini is required for Cu-stimulated Ser/Thr phosphorylation of Cu-(I)ATPase (ATP7B). Journal of Biological Chemistry. 2015. 290(14):8803-19 [Link ↗]
  2. Nesrin M. Hasan*, Arnab Gupta*, Elena Polishchuk, Corey H. Yu, Roman Polishchuk, Oleg Y. Dmitriev, and Svetlana Lutsenko. Molecular events initiating exit of a copper transporting ATPase ATP7B from the Trans-Golgi network. Journal of Biological Chemistry. 2012. 287(43):36041-50 (*equal contributors) [Link ↗]
  3. Arnab Gupta# and Svetlana Lutsenko. Evolution of Copper transporting ATPases in eukaryotic organisms. Current Genomics. 2011;13: 124-133 (#corresponding author) [Link ↗]
  4. Arnab Gupta*, Ashima Bhattacharjee*, Oleg Y. Dmitriev, Sergiy Nokhrin, Lelita Braiterman, Ann Hubbard, Svetlana Lutsenko. Cellular copper levels determine the phenotype of the Arg875 variant of ATP7B/Wilson disease protein. Proceedings of the National Academy of Sciences USA. 2011; 108:5390-5. [Link ↗]
  5. Arnab Gupta, Ishita Chattopadhyay, Shashwata Mukherjee, Mainak Sengupta, Shyamal K Das, Kunal Ray. A Novel COMMD1 Mutation Thr174Met Associated with Elevated Urinary Copper and Signs of Enhanced Apoptotic Cell Death in a Wilson Disease Patient. Behavioral and Brain Functions. 2010; 6:33. [Link ↗]
  6. Natalie Barnes*, Mee Y. Bartee1*, Lita Braiterman, Arnab Gupta, Vladimir Ustiyan, Vesna Zuzel, Jack H. Kaplan, Ann L. Hubbard, and Svetlana Lutsenko. Cell-specific trafficking suggests a new role for renal ATP7B in the intracellular copper storage. Traffic. 2009; 10: 767–779. [Link ↗]
  7. Arnab Gupta and Svetlana Lutsenko. Copper transport in human cells: Mechanism, the role in human diseases, and therapeutic potential. Future Medicinal Chemistry. 2009; 1: 1125-1142. [Link ↗]
  8. Svetlana Lutsenko, Arnab Gupta, Jason Burkhead, Vesna Zuzel. Cellular Multitasking: The dual role of human Cu-ATPases in cofactor delivery and intracellular copper balance. Archives of Biochemistry and Biophysics. 2008; 476(1): 22-32. [Link ↗]
  9. Arnab Gupta, Ishita Chattopadhyay, Sumit Dey, Poonam Nasipuri, Shyamal K. Das, Prasanta K. Gangopadhyay, Kunal Ray. Molecular pathogenesis of Wilson disease among Indians: A perspective on mutation spectrum in ATP7B gene, prevalent defects, clinical heterogeneity and implication towards diagnosis. Cellular & Molecular Neurobiology. 2007, 27:1023-33. [Link ↗]
  10. Arnab Gupta*, Mahua Maulik*, Poonam Nasipuri, Ishita Chattopadhyay, Shyamal K. Das, Prasanta K. Gangopadhyay, IGVC, Kunal Ray. (*Equal contributors) Molecular diagnosis of Wilson disease using prevalent mutations and informative SNP markers. Clinical Chemistry. 2007; 53: 1601-1608. (Highlighted in the editorial) [Link ↗]
  11. Arnab Gupta, Poonam Nasipuri, Shyamal K. Das, Kunal Ray. Simple and effective strategies for Detection of Allele Dropouts in PCR-Based Diagnosis of Wilson disease. Clinical Chemistry. 2006; 52(8):1611-1612. [Link ↗]
  12. Devdeep Aikath*, Arnab Gupta*, Mohammed A. Hashmi, Prasanta K. Gangopadhyay, Shyamal K. Das, Kunal Ray. (*Equal contributors) Subcortical white-matter abnormalities related to drug resistance in Wilson disease. Neurology. 2006; 67(5):878-880. [Link ↗]
  13. Arnab Gupta, Devdeep Aikath, Rajarshi Neogi, Somnath Datta, Kaustuv Basu, Bhaswar Maity, Rajni Trivedi, Jharna Ray, Shyamal K Das, Prasanta K Gangopadhyay, Kunal Ray. Molecular pathogenesis of Wilson Disease: Haplotype analysis, detection of prevalent mutations and genotype-phenotype correlation in Indian patients. Human Genetics. 2005; 118: 49-57. [Link ↗]
  14. Arindam Biswas, Arnab Gupta, Tufan Naiya, Rajarshi Neogi, Somnath Dutta, Subhas Mukherjee, Shyamal K. Das, Kunal Ray, Jharna Ray. Molecular Pathogenesis of Parkinson's Disease: Identification of Mutations in the Parkin Gene in Indian Patients. Parkinsonism and Related Disorders. 2006; 12(7):420-426 [Link ↗]
  15. Arnab Gupta, Neogi R, Mukherjea M, Mukhopadhyay A, Roychoudhury S, Senapati A, Gangopadhyay PK, Ray K. DNA linkage based diagnosis of Wilson disease in asymptomatic siblings. Indian Journal of Medical Research. 2003; 118:208-14 [Link ↗]
  16. Arijit Mukhopadhyay, Arnab Gupta, Saibal Mukherjee, Keya Chaudhuri and Kunal Ray. Did Myocilin evolve from two different primordial proteins? Molecular Vision. 2002, 8: 271-279. (* equal contribution) [Link ↗]

Book chapters

Other publications

Patents

Journals We've Published In

Molecular Biology of the Cell Redox Biology communication biology Journal of Cell Science Journal of Cell Science Journal of Cell Science JBC JBC Cell Reports Human Mutation Traffic Small Metallomics Inorganic Chemistry Small Metallomics Biomaterials Science Membrane Biology