Alakesh was born July 23, 1977 in Midnapore, West Bengal, India. After completing his undergraduate studies from Midnapore College, he decided to move to BHU Varanasi, where he received his Master of Science with in Chemistry. Subsequently, he moved to the IIT Kanpur in 2000 for his doctoral studies in the group of Professor Vinod K. Singh in the area of enantioselective C-C bond forming reactions. After completing his Ph.D. thesis in 2006, he immediately started as a postdoctoral research at the University of California at Berkeley, CA with Professor Richmond Sarpong where he worked in the area of total synthesis of "miscellaneous" class of Lycopodium alkaloids. In December, 2009 he left UC Berkeley and join IISER Bhopal as an Assistant Professor of Chemistry. Since then his group is actively engaged in development of methodologies for C-C bond-forming reactions that took advantage of Lewis-acid catalyzed processes, various oxidative coupling reactions, C-H activations, and enantioselective methodologies. He is working as a Professor of Chemistry at IISER Bhopal since January, 2018. His research group is actively involved in the target oriented total syntheses of various architecturally complex and biologically active natural products.
In May, 2019, he moved to IISER Kolkata on long-leave (lien) to join as a Professor in the Department of Chemical Sciences and setting up a laboratory for Organic Synthesis directed for the total syntheses of architecturally intriguing and biologically relevance alkaloids.