Research Questions
One of the key areas we will be exploring more will be the local crosstalk of different endocytic pathways - clathrin mediated, caveolae etc AND understanding mechanical and molecular remodelling on the membrane by cell stretching. Image analysis (MATLAB and Python-based) with emphasis on customized codes are important for these studies.

Review Articles:
The Plasma Membrane and Mechanoregulation in Cells
Upasana Mukhopadhyay, Tithi Mandal, Madhura Chakraborty, and Bidisha Sinha
ACS Omega Article ASAP

DOI: 10.1021/acsomega.4c01962

Research Articles:

Published: Jan 2024

Mandal T, Biswas A, Ghosh T, Manikandan S, Kundu A, Banerjee A, Mitra D, Sinha B. Mechano-regulation by clathrin pit-formation and passive cholesterol-dependent tubules during de-adhesion. Cell Mol Life Sci. 2024 Jan 13;81(1):43. doi: 10.1007/s00018-023-05072-4. PMID: 38217571; PMCID: PMC10787898.

Research Articles:

Published: Oct 2023

Liu Chinky Shiu Chen, Mandal Tithi, Biswas Parijat, Hoque Md. Asmaul, Bandopadhyay Purbita, Sinha Bishnu Prasad, Sarif Jafar, D’Rozario Ranit, Sinha Deepak Kumar, Sinha Bidisha, Ganguly Dipyaman (2023) Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells eLife 12:RP91903

Published: Oct 2023
Sharma M, Mukherjee S, Shaw AK, Mondal A, Behera A, Das J, Bose A, Sinha B, Sarma JD. Connexin 43 mediated collective cell migration is independent of Golgi orientation. Biol Open. 2023 Oct 15;12(10):bio060006. doi: 10.1242/bio.060006. Epub 2023 Oct 30. PMID: 37815438; PMCID: PMC10629497.

Research Articles:

Published: Oct 2022
Chakraborty M, Sivan A, Biswas A and Sinha B (2022) Early tension regulation coupled to surface myomerger is necessary for the primary fusion of C2C12 myoblasts. Front. Physiol. 13:976715. doi: 10.3389/fphys.2022.976715

Published: 8th March 2022
Effect of heterogeneous substrate adhesivity of follower cells on speed and tension profile of leader cells in primary keratocyte collective cell migration
Madhura Chakraborty, Baishali Mukherjee, Nanditha Nalinakshan, Arikta Biswas, Rajesh Kumble Nayak, Bidisha Sinha
Biol Open (2022) 11 (3): bio058893.
Featured on Cover:

[Submitted on 31 May 2023]
Formation of clathrin-pits and ATP-independent cholesterol-dependent tubules initiates mechano-regulation on de-adhesion
Tithi Mandal, Arikta Biswas, Tanmoy Ghosh, Sreekanth Manikandan, Avijit Kundu, Ayan Banerjee, VDhrubaditya Mitra, Bidisha Sinha

[Submitted on 25 May 2022]
Estimate of entropy generation rate can spatiotemporally resolve the active nature of cell flickering
Sreekanth K Manikandan, Tanmoy Ghosh, Tithi Mandal, Arikta Biswas, Bidisha Sinha, Dhrubaditya Mitra
arXiv:2205.12849 [cond-mat.soft]

> now accepted at PRR

Probing the role of macromolecular crowding in cell volume regulation using fluorescence anisotropy
Parijat Biswas, Dipanjan Ray, Subhamoy Jana, Jibitesh Das, Bidisha Sinha, Deepak Kumar Sinha


Review Article
Published: 23 January 2021
Membrane Homeostasis: The Role of Actin Cytoskeleton
Arikta Biswas, Rinku Kumar and Bidisha Sinha
Journal of the Indian Institute of Science volume 101, pages81–95(2021)


Cell spread area and traction forces determine myosin-II-based cortex thickness regulation
R Kumar, S Saha, B Sinha
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 17 2019

Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
M Dewulf, DV Köster, B Sinha, CV de Lesegno, V Chambon, A Bigot, ...
Nature communications 10 (1), 1974 32 2019

Cholesterol depletion by MβCD enhances cell membrane tension, its variations and reduces integrity
A Biswas, P Kashyap, S Datta, T Sengupta, B Sinha
Biophysical Journal


Cellular and Nuclear Forces: An Overview
B Sinha, A Biswas, GV Soni
Molecular Motors, 1-29


Mapping cell membrane fluctuations reveals their active regulation and transient heterogeneities
A Biswas, A Alex, B Sinha
Biophysical journal 113 (8), 1768-1781