Department: Chemical Sciences (DCS)
Email: a.mukherjee [at] iiserkol.ac.in
Personal Website: Click Here
The AM Group is inspired by the methodology of designing target-specific anticancer agents or fluorescent protein inhibitors using small organic molecules synthesized by students for chosen protein targets of interest. The group also focuses on developing metal complexes that can resist efflux from cells, inhibit proteins relevant to angiogenesis, block kinase phosphorylation, act against cancer stem cells, or stimulate the immune system to recognize cancer. Students in the AM laboratory are trained in all aspects of this work, from synthesis and characterization of compounds to in vitro experiments with cancer and primary cell lines to evaluate cytotoxicity, using both laboratory and institute central facilities. Professor Mukherjee has established an extensive collaborative network spanning India and abroad, including: Dr. Arnab Gupta and Dr. Rahul Das (Department of Biological Sciences, IISER Kolkata); Prof. Sandeep Singh and Prof. Moulinath Acharya (National Institute of Biomedical Genomics, Kalyani); Dr. B. Kiran Kumar (CCMB, Hyderabad); Prof. Abhik Saha (Presidency University, Kolkata, India); Dr. Sergei Boichuk (KSM, Russia); Dr. Julie Gavard (Nantes University, France); Dr. C. T. Supuran (Neurofarba Department, University of Florence, Italy). The research group seeks interested Ph.D. students with a MS/MSc in chemistry and knack for organic synthesis is preferred since the lab also focuses on multi-step (3–7 steps) organic synthesis for developing protein targeted ligands incorporating clinically approved or trial-stage drugs through the solvent exposed end functionalization/modification. The students then make the metal complexes with them and study their properties. They even do Structure Activity Relation (SAR) studies with fully organic compounds from 2023.
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