Amirul Islam Mallick

Associate Professor
Dept: Biological Sciences (DBS)
E-mail: amallick [at] iiserkol.ac.in
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Research Interest:
 

Following entry into host via mucosal portal pathogen counter primary host defence through physical barrier and first line of defence via innate immune response. To counter these impediments, pathogens uses wide range of strategies that enable them to adhere and invade the gut epithelium followed by the induction of host inflammatory response. Specifically, host pathogen interaction at the mucosal surface leading to either immunity or infection is a multi-factorial process and depends on the susceptibility of the host, repertoire of virulence factors, mode of pathogen entry and transmission as well as many environmental factors. Depending on the nature of the pathogen, effective host response at the mucosal surface can be achieved by directing memory and effector immune cells to the mucosal membranes through tissue-specific homing receptors. Therefore, understanding the contributions of the individual host cell types and molecules towards infection or immunity provide stronger basis for developing efficacious control measures against emerging mucosal pathogen. In the past decade, the successful development of mucosal vaccines against many enteric and respiratory pathogens has boosted our interest in the field of mucosal immunity. With this background, we are currently studying the role of virulence repertories of emerging mucosal pathogens such as Influenza virus and Campylobacter jejuni in effective host response and exploring their potential as future vaccine candidate.

Academic Background:

  1. PhD (Biotechnology), Interdisciplinary Biotechnology Unit (Aligarh Muslim University), 2008, Specialization in Molecular Immunology
  2. MVSc (Microbiology and Immunology), Mathura Veterinary College (CSA University of Agriculture & Technology, Kanpur), 2003
  3. BVSc and A.H. (Veterinary Science and Animal Husbandry), F/O Veterinary and Animal Scs. (West Bengal University of Animal & Fishery Scs,Kol), 2001

Positions:

  1. Associate Professor, IISER Kolkata ( - )
  2. Assistant Professor, Indian Institute of Science, Education and Research Kolkata (2014 - 2019)
  3. Post Doctoral Fellow, Sunnybrook Research Institute, University of Toronto, ON, Canada (2010 - 2014)
  4. Post Doctoral Fellow, Ontario Veterinary College, University of Guelph, Canada (2008 - 2010)

Awards and Honors:

  1. ICMR -DHR International Fellow from Indian Council of Medical Research (2019)
  2. R&D Grant from DBT, Govt of India (2017)
  3. Early Career Research Award from SCIENCE & ENGINEERING RESEARCH BOARD (SERB), India (2016)
  4. Canadian Breast Cancer Foundation Fellowship from Canadian Breast Cancer Foundation (2012)
  5. ICI - CSI International Travel Award from International Congress of Immunology (ICI) and Canadian Society for Immunology (CSI) (2010)
  6. Senior Research Fellowship from Council of Scientific and Industrial Research (CSIR), New Delhi (2006)
  7. Post Graduate merit scholarship from CSA University of Agrl. and Technol, Kapnur (2001)
  8. National Merit Scholarship from Ministry of Human Resource Development, Government of India (1996)

Selected Publications:

  1. Lahiri, Aritraa; Sharif, Shayan and Mallick, Amirul I. 2019."Intragastric delivery of recombinant Lactococcus lactis displaying ectodomain of influenza matrix protein 2 (M2e) and neuraminidase (NA) induced focused mucosal and systemic immune responses in chickens. ." Molecular Immunology (ELSEVIER), X, X
  2. Singh, Ankita; Nissa, Khairun; Bhattacharyya, Sudipta and Mallick, Amirul I. 2019."Immunogenicity and protective efficacy of mucosal delivery of recombinant hcp of Campylobacter jejuni Type VI secretion system (T6SS) in chickens." Molecular Immunology (ELSEVIER), 111, 182-197
  3. Pal, Aruna; Pal, Abantika; Mallick, Amirul I; Biswas, Purendu and Chaterjee, Pareshnath. 2019."Molecular characterization of Bu-1 and TLR2 gene in Haringhata Black chicken." Genomics, X, X
  4. Singh, Ankita and Mallick, Amirul I.. 2019."Role of putative virulence traits of Campylobacter jejuni in regulating differential host immune responses." Journal of Microbiology (JN), (Springer), 57, 298-309
  5. Wahid, Aws Abdul; Huang, Eric HB; Mallick, Amirul Islam and Gariepy, Jean. 2012."A focused immune response targeting the homotypic binding domain of the carcinoembryonic antigen blocks the establishment of tumour foci in vivo. ." International Journal of Cancer , 131, 2839-2845

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