... towards excellence in science

An Autonomous Institution, Under the Ministry of Education, Government of India

Purba Mukherjee

Assistant Professor
Dept: Biological Sciences (DBS)
E-mail: pmukherjee [at]
Personal homepage: Click Here

Research Interest:

My group is interested in developing novel approaches for biotherapeutic synthesis, design and discovery. In the process, we want to unravel the mechanisms that control and modulate the behavior of enzymes and proteins.

Academic Background:

  1. PhD (Biomedical Sciences), State University of New York, Albany, 2014
  2. B.Tech (Biotechnology), Heritage Institute of Technology (West Bengal University of Technology), 2008


  1. Assistant Professor, IISER Kolkata (current)
  2. Postdoctoral researcher, Scripps Research Institute (2015 - 2019)
  3. Postdoctoral researcher, Harvard Medical School (2014 - 2015)

Awards and Honors:

  1. WSA Postdoctoral Fellowship from American Heart Association (2017)

Selected Publications:

  1. Mukherjee, Purba; Lyden, Patrick; Fernandez, Jose A.; Davis, Thomas P.; Pryor, Kent E.; Zlokovic, Berislav V. and Griffin, John H.. 2020."3K3A-activated protein C variant does not interfere with the plasma clot lysis activity of tenecteplase." Stroke, 51, 2236–2239
  2. Mukherjee, Purba; Leman, Luke J.; Griffin, John H. and Ghadiri, M. Reza. 2018."Design of a DNA-Programmed Plasminogen Activator." JACS, 140, 15516-24
  3. Mukherjee*, Purba; Wilson*, Ryan C.; Lahiri, Indrajit and Pata, Janice D.. 2014."Three residues of the interdomain linker determine the conformation and single-base deletion fidelity of Y-family translesion polymerases." J Biol Chem., 289, 6323-31
  4. Mukherjee, Purba; Lahiri, Indrajit and Pata, Janice D.. 2013."Human polymerase kappa uses a template-slippage deletion mechanism, but can realign the slipped strands to favour base substitution mutations over deletions ." Nucleic Acids Research, 41, 5024-35

All Publications: Click Here