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ভারতীয় বিজ্ঞান শিক্ষা এবং গবেষণা প্রতিষ্ঠান কলকাতা

भारतीय विज्ञान शिक्षा एवं अनुसंधान संस्थान कोलकाता

INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH KOLKATA

... towards excellence in science

An Autonomous Institution, Under the Ministry of Education, Government of India

Rahul Das

Associate Professor
Dept: Biological Sciences (DBS)
E-mail: rahul.das [at] iiserkol.ac.in

All Publications:

  1. Chakraborty, Manas Pratim; Bhattacharyya, Sudipta; Roy, Souryadip; Bhattacharya, Indira; Das, Rahul and Mukherjee, Arindam. 2021."Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative.." J Biol. Chem., 296, 100449
  2. Acharya, Sourav; Maji, Moumita; Chakraborty, Manas Pratim; Bhattacharya, Indira; Das, Rahul; Gupta, Arnab and Mukherjee, Arindam. 2021."Disruption of the Microtubule Network and Inhibition of VEGFR2 Phosphorylation by Cytotoxic N, O-Coordinated Pt(II) and Ru(II) Complexes of Trimethoxy Aniline-Based Schiff Bases." Inorg. Chem, 60, 3418-3430
  3. Soumyadip, Bhunia; Gangopadhyay, Kaustav; Ghosh, Ashutosh; Seth, Sourav Kanti; Das, Rahul and Purkayastha, Pradipta. 2021."Arginine-Modified Fluorescent Gold Nanoclusters for Förster Resonance Energy Transfer with a Hemicyanine Dye: A Biofriendly Approach." ACS Appl. Nano Mater, 4, 305-312
  4. Sinha, Sushant K; Das, Shibashis; Konar, Sukanya; Ghorai, Pradip Kr.; Das, Rahul and Datta, Supratim. 2020."Elucidating the regulation of glucose tolerance in a ?-glucosidase from Halothermothrix orenii by active site pocket engineering and computational analysis." International Journal of Biological Macromolecules, 156, 621
  5. Mukherjee, Mousumi; Gangopadhyay, Kaustav; Das, Rahul and Purkayastha, Pradipta. 2020." Development of Non-ionic Surfactant and Protein-Coated Ultrasmall Silver Nanoparticles: Increased Viscoelasticity Enables Potency in Biological Applications." ACS Omega, 5, 8999-9006
  6. Gangopadhyay, Kaustav; Manna, Bharat; Roy, Swarnendu; Kumari, Sunitha; Debnath, Olivia; Chowdhury, Subhankar; Ghosh, Amit and Das, Rahul. 2020."An allosteric hot spot in the tandem-SH2 domain of ZAP-70 regulates T-cell signaling." Biochemical Journal, 477, 1287–1308
  7. Sharma, R; Kumar, P; Kaushal, V; Das, R and Navani, N Kumar. 2018."A novel protein tyrosine phosphatase like phytase from Lactobacillus fermentum NKN51: Cloning, characterization and application in mineral release for food technology applications.." Bioresour Technol, 249, 1000-1008
  8. Kovacs*, E; Das*, R; Wang, Q; Collier, T S; Cantor, A; Huang, Y; Wong, K; Mirza, A; Barros, T; Grob, P; Jura, N; Bose, R and Kuriyan, J. 2015."Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor." Mol Cell Biol, 35, 3083-3102
  9. Iwig, J S; Vercoulen*, Y; Das*, R; Barros, T; Limnander, A; Che, Y; Pelton, J G; Wemmer, D E; Roose, J P and Kuriyan, J. 2013."The structural basis for autoinhibition of thr Ras-specific exchange factor RasGRP1." eLife, ,
  10. Barker, C A; Allison, S E; Zlitni, S; Nguyen, N D; Das, R; Melacini, G; Capretta, A A and Brown, E D. 2013."Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA." Bioorg Med Chem Lett, 15, 2426-31
  11. Endres*, N; Das*, R; Smith, A W; Arkhipov, A; Kovacs, E; Huang, Y; Pelton, J G; Shan, Y; Shaw, D E; Wemmer, D E; Groves, J T and Kuriyan, J. 2013."Conformational coupling across the plasma membrane in activation of the EGF receptor.." Cell, 152, 543 – 556
  12. Arkhipov, A; Shan, Y; Das, R; Endres, N; Eastwoo, M P; Wemmer, D E; Kuriyan, J and Shaw, D E. 2013."Architecture and membrane interactions of the EGF receptor." Cell, 152, 557 – 569
  13. Selvaratnam, R; Mazhab-Jafari, M T; Das, R and Melacini, G. 2012."The auto-inhibitory role of the EPAC hinge helix as mapped by NMR." PloS One, 7, e48707
  14. Selvaratnam, R; VanSchouwen, B; Fogolari, F; Mazhab-Jafari, M T; Das, R and Melacini, G. 2012."The projection analysis of NMR chemical shift reveals extended EPAC autoinhibition determinants. ." Biophys J. , 102, , 630 -639
  15. Endres, N F; Engel, K; Das, R; Kovacs, E and Kuriyan, J. 2011."Regulation of the catalytic activity of the EGF receptor.." . Current Opinion in Structural Biology , 6, 777 – 784
  16. McNicholl, E T; Das, R; SilDas, S; Taylor, S S and Melacini, G. 2010."Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutants." Journal of Biological Chemistry , 285, 15523-37
  17. Pathania, R; Zlitni, S; Barker, C; Das, R; Gerritsma, D A; Lebert, J; Awuah, E; Melacini, G; Capretta, F A and Brown, E D. 2009."Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. ." Nature Chemical Biology , 5, 849 – 856
  18. Das, R; Chowdhury, S; Mazhab-Jafari, M T; Sildas, S; Selvaratnam, R and Melacini, G. 2009."Dynamically driven ligand selectivity in cyclic nucleotide binding domains.." Journal of Biological Chemistry, 284, 23682-96
  19. Jura, N; Endres, N F; Engel, K; Deindl, S; Das, R; Lamers, M H; Wemmer, D E; Zhang, X and Kuriyan, J. 2009."Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segments. ." Cell, 137, 1293-1301
  20. Das, R; Mazhab-Jafari, M T; Chowdhury, S; SilDas, S; Selvaratnam, R and Melacini, G. 2008."Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP.." Journal of Biological Chemistry , 283, 19691-03
  21. Mazhab-Jafari, M T; Das, R; Fotheringham, S A; SilDas, S; Chowdhury, S and Melacini, G. 2007."Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states. ." Journal of American Chemical Society , 129, 14482-92
  22. Abu-Abed, M; Das, R; Wang, L and Melacini, G. 2007."Definition of an electrostatic relay switch critical for the cAMP-dependent activation of protein kinase A as revealed by the D170A mutant of RIalpha.." Proteins: Structure, Function and Bioinformatics, 69, 112-124
  23. Milojevic, J; Esposito, V; Das, R and Melaacini, G. 2007."Understanding the molecular basis for the inhibition of the Alzheimer’s Abeta-peptide oligomerization by human serum albumin using saturation transfer deference and off-resonance NMR spectroscopy. ." Journal of American Chemical Society, 129, 4282-4290
  24. Das, R and Giuseppe, M. 2007."A model for agonism and antagonism in an ancient ubiquitous cAMP-binding domain.." Journal of Biological Chemistry, 282, 581-593
  25. Das, R; Esposito, V; Abu-Abed, M; Anand, G S; Taylor, S S and Giuseppe, M. 2007."cAMP activation of PKA defines an ancient signaling mechanism." Proceedings of National Academy of Sciences U.S.A., 104, 93-98
  26. Milojevic, J; Esposito, V; Das, R and Melacini, G. 2006."Analysis and parametric optimization of 1H off-resonance relaxation NMR experiments designed to map polypeptide self-recognition and other noncovalent interactions.." Journal of Physical Chemistry B., 110, 20664-70
  27. Esposito, V; Sjoberg, T; Das, R; Brown, S; Taylor, S S and Melacini, G. 2006."NMR assignment of the cAMP-binding domain A of the PKA regulatory subunit." Journal of Biomolecular NMR, 36, 64
  28. Das, R; Abu-Abed, M and Melacini, G. 2006."Mapping allostery through equilibrium perturbation NMR spectroscopy.." Journal of American Chemical Society , 128, 8406-8407
  29. Gavina, J M; Das, R and Britz-McKinnin, P. 2006."Dynamic unfolding of a regulatory subunit of cAMP-dependent protein kinase by capillary electrophoresis: Impact of cAMP dissociation on protein stability.." Electrophoresis, 21, 4196-4204
  30. Esposito, V; Das, R and Melacini, G. 2005."Mapping polypeptide self-recognition through 1H off-resonance relaxation.." Journal of American Chemical Society , 127, 9358-9359