... towards excellence in science

An Autonomous Institution, Under the Ministry of Education, Government of India

Rahul Das

Associate Professor
Dept: Biological Sciences (DBS)
E-mail: rahul.das [at]

All Publications:

  1. Chakraborty, Manas Pratim; Bhattacharyya, Sudipta; Roy, Souryadip; Bhattacharya, Indira; Das, Rahul and Mukherjee, Arindam. 2021."Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative.." J Biol. Chem., 296, 100449
  2. Acharya, Sourav; Maji, Moumita; Chakraborty, Manas Pratim; Bhattacharya, Indira; Das, Rahul; Gupta, Arnab and Mukherjee, Arindam. 2021."Disruption of the Microtubule Network and Inhibition of VEGFR2 Phosphorylation by Cytotoxic N, O-Coordinated Pt(II) and Ru(II) Complexes of Trimethoxy Aniline-Based Schiff Bases." Inorg. Chem, 60, 3418-3430
  3. Soumyadip, Bhunia; Gangopadhyay, Kaustav; Ghosh, Ashutosh; Seth, Sourav Kanti; Das, Rahul and Purkayastha, Pradipta. 2021."Arginine-Modified Fluorescent Gold Nanoclusters for Förster Resonance Energy Transfer with a Hemicyanine Dye: A Biofriendly Approach." ACS Appl. Nano Mater, 4, 305-312
  4. Sinha, Sushant K; Das, Shibashis; Konar, Sukanya; Ghorai, Pradip Kr.; Das, Rahul and Datta, Supratim. 2020."Elucidating the regulation of glucose tolerance in a ?-glucosidase from Halothermothrix orenii by active site pocket engineering and computational analysis." International Journal of Biological Macromolecules, 156, 621
  5. Mukherjee, Mousumi; Gangopadhyay, Kaustav; Das, Rahul and Purkayastha, Pradipta. 2020." Development of Non-ionic Surfactant and Protein-Coated Ultrasmall Silver Nanoparticles: Increased Viscoelasticity Enables Potency in Biological Applications." ACS Omega, 5, 8999-9006
  6. Gangopadhyay, Kaustav; Manna, Bharat; Roy, Swarnendu; Kumari, Sunitha; Debnath, Olivia; Chowdhury, Subhankar; Ghosh, Amit and Das, Rahul. 2020."An allosteric hot spot in the tandem-SH2 domain of ZAP-70 regulates T-cell signaling." Biochemical Journal, 477, 1287–1308
  7. Sharma, R; Kumar, P; Kaushal, V; Das, R and Navani, N Kumar. 2018."A novel protein tyrosine phosphatase like phytase from Lactobacillus fermentum NKN51: Cloning, characterization and application in mineral release for food technology applications.." Bioresour Technol, 249, 1000-1008
  8. Kovacs*, E; Das*, R; Wang, Q; Collier, T S; Cantor, A; Huang, Y; Wong, K; Mirza, A; Barros, T; Grob, P; Jura, N; Bose, R and Kuriyan, J. 2015."Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor." Mol Cell Biol, 35, 3083-3102
  9. Iwig, J S; Vercoulen*, Y; Das*, R; Barros, T; Limnander, A; Che, Y; Pelton, J G; Wemmer, D E; Roose, J P and Kuriyan, J. 2013."The structural basis for autoinhibition of thr Ras-specific exchange factor RasGRP1." eLife, ,
  10. Barker, C A; Allison, S E; Zlitni, S; Nguyen, N D; Das, R; Melacini, G; Capretta, A A and Brown, E D. 2013."Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA." Bioorg Med Chem Lett, 15, 2426-31
  11. Endres*, N; Das*, R; Smith, A W; Arkhipov, A; Kovacs, E; Huang, Y; Pelton, J G; Shan, Y; Shaw, D E; Wemmer, D E; Groves, J T and Kuriyan, J. 2013."Conformational coupling across the plasma membrane in activation of the EGF receptor.." Cell, 152, 543 – 556
  12. Arkhipov, A; Shan, Y; Das, R; Endres, N; Eastwoo, M P; Wemmer, D E; Kuriyan, J and Shaw, D E. 2013."Architecture and membrane interactions of the EGF receptor." Cell, 152, 557 – 569
  13. Selvaratnam, R; Mazhab-Jafari, M T; Das, R and Melacini, G. 2012."The auto-inhibitory role of the EPAC hinge helix as mapped by NMR." PloS One, 7, e48707
  14. Selvaratnam, R; VanSchouwen, B; Fogolari, F; Mazhab-Jafari, M T; Das, R and Melacini, G. 2012."The projection analysis of NMR chemical shift reveals extended EPAC autoinhibition determinants. ." Biophys J. , 102, , 630 -639
  15. Endres, N F; Engel, K; Das, R; Kovacs, E and Kuriyan, J. 2011."Regulation of the catalytic activity of the EGF receptor.." . Current Opinion in Structural Biology , 6, 777 – 784
  16. McNicholl, E T; Das, R; SilDas, S; Taylor, S S and Melacini, G. 2010."Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutants." Journal of Biological Chemistry , 285, 15523-37
  17. Pathania, R; Zlitni, S; Barker, C; Das, R; Gerritsma, D A; Lebert, J; Awuah, E; Melacini, G; Capretta, F A and Brown, E D. 2009."Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. ." Nature Chemical Biology , 5, 849 – 856
  18. Das, R; Chowdhury, S; Mazhab-Jafari, M T; Sildas, S; Selvaratnam, R and Melacini, G. 2009."Dynamically driven ligand selectivity in cyclic nucleotide binding domains.." Journal of Biological Chemistry, 284, 23682-96
  19. Jura, N; Endres, N F; Engel, K; Deindl, S; Das, R; Lamers, M H; Wemmer, D E; Zhang, X and Kuriyan, J. 2009."Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segments. ." Cell, 137, 1293-1301
  20. Das, R; Mazhab-Jafari, M T; Chowdhury, S; SilDas, S; Selvaratnam, R and Melacini, G. 2008."Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP.." Journal of Biological Chemistry , 283, 19691-03
  21. Mazhab-Jafari, M T; Das, R; Fotheringham, S A; SilDas, S; Chowdhury, S and Melacini, G. 2007."Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states. ." Journal of American Chemical Society , 129, 14482-92
  22. Abu-Abed, M; Das, R; Wang, L and Melacini, G. 2007."Definition of an electrostatic relay switch critical for the cAMP-dependent activation of protein kinase A as revealed by the D170A mutant of RIalpha.." Proteins: Structure, Function and Bioinformatics, 69, 112-124
  23. Milojevic, J; Esposito, V; Das, R and Melaacini, G. 2007."Understanding the molecular basis for the inhibition of the Alzheimer’s Abeta-peptide oligomerization by human serum albumin using saturation transfer deference and off-resonance NMR spectroscopy. ." Journal of American Chemical Society, 129, 4282-4290
  24. Das, R and Giuseppe, M. 2007."A model for agonism and antagonism in an ancient ubiquitous cAMP-binding domain.." Journal of Biological Chemistry, 282, 581-593
  25. Das, R; Esposito, V; Abu-Abed, M; Anand, G S; Taylor, S S and Giuseppe, M. 2007."cAMP activation of PKA defines an ancient signaling mechanism." Proceedings of National Academy of Sciences U.S.A., 104, 93-98
  26. Milojevic, J; Esposito, V; Das, R and Melacini, G. 2006."Analysis and parametric optimization of 1H off-resonance relaxation NMR experiments designed to map polypeptide self-recognition and other noncovalent interactions.." Journal of Physical Chemistry B., 110, 20664-70
  27. Esposito, V; Sjoberg, T; Das, R; Brown, S; Taylor, S S and Melacini, G. 2006."NMR assignment of the cAMP-binding domain A of the PKA regulatory subunit." Journal of Biomolecular NMR, 36, 64
  28. Das, R; Abu-Abed, M and Melacini, G. 2006."Mapping allostery through equilibrium perturbation NMR spectroscopy.." Journal of American Chemical Society , 128, 8406-8407
  29. Gavina, J M; Das, R and Britz-McKinnin, P. 2006."Dynamic unfolding of a regulatory subunit of cAMP-dependent protein kinase by capillary electrophoresis: Impact of cAMP dissociation on protein stability.." Electrophoresis, 21, 4196-4204
  30. Esposito, V; Das, R and Melacini, G. 2005."Mapping polypeptide self-recognition through 1H off-resonance relaxation.." Journal of American Chemical Society , 127, 9358-9359