Babu Sudhamalla

Assistant Professor
Dept: Biological Sciences (DBS)
E-mail: s.babu [at] iiserkol.ac.in
Personal homepage: Click Here

Research Interest:
 

The research in my laboratory focuses on following areas of epigenetic mechanisms that are at best partially understood: (i) reversal of DNA methylation (ii) epigenetic readers and erasers of histone acetylation. Dysregulation in above-mentioned processes can cause chromosomal instability, and eventually lead to multiple disorders including cancer and neurological diseases. Molecular rationale linking these epigenetic events to disease states is lacking. For example, how mutations in various gene products in these pathways play role in tumorigenesis, tumor progression and metastasis is not completely clear. To address these questions, we take a multidisciplinary approach that integrate protein engineering, unnatural amino acid mutagenesis, biochemistry, proteomics, mammalian tissue culture system and bioinformatics to interrogate cellular machineries towards molecular understanding of epigenetic mechanisms in human health and disease.

Academic Background:

  1. Ph.D. (Chemistry), University of Hyderabad, 2014
  2. M.Tech. (Bioinformatics), University of Hyderabad, 2009
  3. B.Tech. (Biotechnology), JNTU-Hyderabad, 2006

Positions:

  1. Assistant Professor, IISER Kolkata ( - )
  2. Post Doctoral Fellow, University of Pittsburgh (2014 - 2018)

Awards and Honors:

  1. Ramalingaswami Re-entry Fellowship from Dept of Biotechnology (2019)

Selected Publications:

  1. Wagner, S; Sudhamalla, B; Mannes, P; Sappa, S; Kavoosi, S; Dey, D; Wang, S and Islam, K. 2020."Engineering bromodomains with a photoactive amino acid by engaging 'Privileged' tRNA synthetases." Chem. Commun., 56, 3641
  2. Kavoosi, S; Sudhamalla, B; Dey, D; Shriver, K; Arora, S; Sappa, S and Islam, K. 2019."Site-and degree-specific C–H oxidation on 5-methylcytosine homologues for probing active DNA demethylation." Chem. Sci, 10, 10550
  3. Sudhamalla, B; Wang, S; Snyder, V; Kavoosi, S; Arora, S and Islam, K. 2018." Complementary Steric Engineering at the Protein-Ligand Interface for Analogue-Sensitive TET Oxygenases." J. Am. Chem. Soc., 140(32), 10263
  4. Sudhamalla, B; Dey, D; Breski, M and Islam, K. 2017."A rapid mass spectrometric method for the measurement of catalytic activity of ten-eleven translocation enzymes." Anal Biochem. , 534, 28
  5. Sudhamalla, B; Dey, D; Breski, M; Nguyen, T and Islam, K. 2017."Site-specific azide-acetyllysine photochemistry on epigenetic readers for interactome profiling." Chem Sci. , 8(6) , 4250

All Publications: Click Here