Sudhamalla Babu
Assistant Professor
Dept: Biological Sciences (DBS)
E-mail: s.babu [at] iiserkol.ac.in
Personal homepage: Click Here
The research in my laboratory focuses on following areas of epigenetic mechanisms that are at best partially understood: (i) reversal of DNA methylation (ii) epigenetic readers and erasers of histone acetylation. Dysregulation in above-mentioned processes can cause chromosomal instability, and eventually lead to multiple disorders including cancer and neurological diseases. Molecular rationale linking these epigenetic events to disease states is lacking. For example, how mutations in various gene products in these pathways play role in tumorigenesis, tumor progression and metastasis is not completely clear. To address these questions, we take a multidisciplinary approach that integrate protein engineering, unnatural amino acid mutagenesis, biochemistry, proteomics, mammalian tissue culture system and bioinformatics to interrogate cellular machineries towards molecular understanding of epigenetic mechanisms in human health and disease.
- Ph.D. (Biochemistry), University of Hyderabad, 2014
- M.Tech. (Bioinformatics), University of Hyderabad, 2009
- B.Tech. (Biotechnology), JNTU-Hyderabad, 2006
- Assistant Professor, IISER Kolkata (current)
- Post Doctoral Fellow, University of Pittsburgh (2014 - 2018)
- Ramalingaswami Re-entry Fellowship from Dept of Biotechnology (2019)
- Bardhan, I; Barman, S; Roy, A and Sudhamalla, B. 2023."Novel insights into the recognition of acetylated histone H4 tail by the TRIM24 PHD-Bromo module." Biochem J, 480, 629-647
- Yadav, Y; Barman, S; Roy, A; Padhan, J and Sudhamalla, B. 2023."Uncovering the Domain-Specific Interactome of the TAF1 Tandem Reader Using Site-Specific Azide-Acetyllysine Photochemistry." Biochemistry, 62, 270-280
- Barman, S; Roy, A; Padhan, J and Sudhamalla, B. 2022."Molecular Insights into the Recognition of Acetylated Histone Modifications by the BRPF2 Bromodomain." Biochemistry, 61, 1774-1789
- Kuwik, J; Wagner, S; Sudhamalla, B; Debiec, R and Islam, K. 2022."Hydrophobic Cavity Directed Azide-Acetyllysine Photochemistry for Profiling Non-Histone Interacting Partners of Bromodomain Protein 1." RSC Chemical Biology, 3, 1061-1068
- Roy, A; Barman, S; Padhan, J and Sudhamalla, B. 2021."Engineering an acetyllysine reader with a photocrosslinking amino acid for interactome profiling." Chem. Commun, 57, 9866-9869