... towards excellence in science

An Autonomous Institution, Under the Ministry of Education, Government of India

Sudhamalla Babu

Assistant Professor
Dept: Biological Sciences (DBS)
E-mail: s.babu [at]

All Publications:

  1. Barman, S; Padhan, J and Sudhamalla, B. 2024."Uncovering the non-histone interactome of the BRPF1 bromodomain using site-specific azide-acetyllysine photochemistry." J. Biol. Chem, 300, 105551
  2. Barman, S; Bardhan, I; Padhan, J and Sudhamalla, B. 2023."Integrated virtual screening and MD simulation approaches toward discovering potential inhibitors for targeting BRPF1 bromodomain in hepatocellular carcinoma." J. Mol. Graph. Model., 126, 108642
  3. Bardhan, I; Barman, S; Roy, A and Sudhamalla, B. 2023."Novel insights into the recognition of acetylated histone H4 tail by the TRIM24 PHD-Bromo module." Biochem J, 480, 629-647
  4. Yadav, Y; Barman, S; Roy, A; Padhan, J and Sudhamalla, B. 2023."Uncovering the Domain-Specific Interactome of the TAF1 Tandem Reader Using Site-Specific Azide-Acetyllysine Photochemistry." Biochemistry, 62, 270-280
  5. Barman, S; Roy, A; Padhan, J and Sudhamalla, B. 2022."Molecular Insights into the Recognition of Acetylated Histone Modifications by the BRPF2 Bromodomain." Biochemistry, 61, 1774-1789
  6. Kuwik, J; Wagner, S; Sudhamalla, B; Debiec, R and Islam, K. 2022."Hydrophobic Cavity Directed Azide-Acetyllysine Photochemistry for Profiling Non-Histone Interacting Partners of Bromodomain Protein 1." RSC Chemical Biology, 3, 1061-1068
  7. Roy, A; Barman, S; Padhan, J and Sudhamalla, B. 2021."Engineering an acetyllysine reader with a photocrosslinking amino acid for interactome profiling." Chem. Commun, 57, 9866-9869
  8. Barman, S; Roy, A; Bardhan, I; Kandasamy, T; Shivani, S and Sudhamalla, B. 2021."Insights into the Molecular Mechanisms of Histone Code Recognition by the BRPF3 Bromodomain." Chem Asian J, 16, 3404-3412
  9. Sappa, S; Dey, D; Sudhamalla, B and Islam, K. 2021."Catalytic Space Engineering as a Strategy to Activate C-H Oxidation on 5-Methylcytosine in Mammalian Genome." J Am Chem Soc ., 143, 11891
  10. Wagner, S; Sudhamalla, B; Mannes, P; Sappa, S; Kavoosi, S; Dey, D; Wang, S and Islam, K. 2020."Engineering bromodomains with a photoactive amino acid by engaging 'Privileged' tRNA synthetases." Chem. Commun., 56, 3641
  11. Kavoosi, S; Sudhamalla, B; Dey, D; Shriver, K; Arora, S; Sappa, S and Islam, K. 2019."Site-and degree-specific C-H oxidation on 5-methylcytosine homologues for probing active DNA demethylation." Chem. Sci, 10, 10550
  12. Sudhamalla, B; Wang, S; Snyder, V; Kavoosi, S; Arora, S and Islam, K. 2018." Complementary Steric Engineering at the Protein-Ligand Interface for Analogue-Sensitive TET Oxygenases." J. Am. Chem. Soc., 140(32), 10263
  13. Sudhamalla, B; Dey, D; Breski, M and Islam, K. 2017."A rapid mass spectrometric method for the measurement of catalytic activity of ten-eleven translocation enzymes." Anal Biochem. , 534, 28
  14. Perell, GT; Mishra, NK; Sudhamalla, B; Ycas, PD; Islam, K and Pomerantz, WCK. 2017."Specific Acetylation Patterns of H2A.Z Form Transient Interactions with the BPTF Bromodomain." Biochemistry, 56(35) , 4607
  15. Sudhamalla, B; Dey, D; Breski, M; Nguyen, T and Islam, K. 2017."Site-specific azide-acetyllysine photochemistry on epigenetic readers for interactome profiling." Chem Sci. , 8(6) , 4250
  16. Breski, M; Dey, D; Obringer, S; Sudhamalla, B and Islam, K. 2016."Engineering Biological C-H Functionalization Leads to Allele-Specific Regulation of Histone Demethylases." J. Am. Chem. Soc. , 138 (41) , 13505
  17. Sudhamalla, B; Kumar, M; Roy, KR; Kumar, RS and Bhuyan, AK. 2013."Cysteine endoprotease activity of human ribosomal protein S4 is entirely due to the C-terminal domain, and is consistent with Michaelis-Menten mechanism." Biochim Biophys Acta., 1830(11), 5342
  18. Sudhamalla, B; Kumar, M; Kumar, RS; P, Sashi; UM, Yasin; D, Ramakrishna; Rao, PN and Bhuyan, AK. 2013."Enzyme dimension of the ribosomal protein S4 across plant and animal kingdoms." Biochim Biophys Acta., 1830(11), 5335
  19. M, Yadaiah; Sudhamalla, B; Rao, PN; Roy, KR; D, Ramakrishna; Hussain Syed, G; Ramaiah, KV and Bhuyan, AK. 2013."Arrested cell proliferation through cysteine protease activity of eukaryotic ribosomal protein S4." FASEB J. , 27(2), 803
  20. Sudhamalla, B; M, Yadaiah; D, Ramakrishna and AK, Bhuyan. 2012."Cysteine protease attribute of eukaryotic ribosomal protein S4." Biochim Biophys Acta., 1820(10), 1535
  21. S, Sanchita; R, Chauhan; G, Soni; Sudhamalla, B and A, Sharma. 2012."Docking and molecular dynamics studies of peptide inhibitors of ornithine decarboxylase: a rate-limiting enzyme for the metabolism of Fusarium solani." J Biomol Struct Dyn., 31(8), 874
  22. Mamidala, P; AJ, Wijeratne; S, Wijeratne; K, Kornacker; Sudhamalla, B; LJ, Rivera-Vega; T, Hoelmer A, Meulia; SC, Jones and Mittapalli, O. 2012."RNA-Seq and molecular docking reveal multi-level pesticide resistance in the bed bug." BMC Genomics., 13, 6
  23. M, Yadaiah; P, Nageswara Rao; Sudhamalla, B; D, Ramakrishna; U, Mahammad Yasin and AK, Bhuyan. 2012."Cloning, Escherichia coli expression, purification, characterization, and enzyme assay of the ribosomal protein S4 from wheat seedlings (Triticum vulgare)." Protein Expr Purif., 81(1), 55
  24. Sudhamalla, B; Gokara, M; Ahalawat, N; Amooru, DG and Subramanyam, R. 2010."Molecular dynamics simulation and binding studies of beta-sitosterol with human serum albumin and its biological relevance." J Phys Chem B., 114(27), 9054
  25. Neelam, S; Gokara, M; Sudhamalla, B; Amooru, DG and Subramanyam, R. 2010."Interaction studies of coumaroyltyramine with human serum albumin and its biological importance." J Phys Chem B., 114(8), 3005
  26. Gokara, M; Sudhamalla, B; Amooru, DG and Subramanyam, R. 2010."Molecular interaction studies of trimethoxy flavone with human serum albumin." PLoS One., 5(1), e8834
  27. Subramanyam, R; Goud, M; Sudhamalla, B; Reddeem, E; Gollapudi, A; Nellaepalli, S; Yadavalli, V; Chinnaboina, M and Amooru, DG. 2009."Novel binding studies of human serum albumin with trans-feruloyl maslinic acid." J Photochem Photobiol B., 95(2), 81