Sudhamalla Babu
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Assistant Professor
Dept: Biological Sciences (DBS)
E-mail: s.babu [at] iiserkol.ac.in
All Publications:
- Barman, S; Padhan, J and Sudhamalla, B. 2024."Uncovering the non-histone interactome of the BRPF1 bromodomain using site-specific azide-acetyllysine photochemistry." J. Biol. Chem, 300, 105551
- Barman, S; Bardhan, I; Padhan, J and Sudhamalla, B. 2023."Integrated virtual screening and MD simulation approaches toward discovering potential inhibitors for targeting BRPF1 bromodomain in hepatocellular carcinoma." J. Mol. Graph. Model., 126, 108642
- Bardhan, I; Barman, S; Roy, A and Sudhamalla, B. 2023."Novel insights into the recognition of acetylated histone H4 tail by the TRIM24 PHD-Bromo module." Biochem J, 480, 629-647
- Yadav, Y; Barman, S; Roy, A; Padhan, J and Sudhamalla, B. 2023."Uncovering the Domain-Specific Interactome of the TAF1 Tandem Reader Using Site-Specific Azide-Acetyllysine Photochemistry." Biochemistry, 62, 270-280
- Barman, S; Roy, A; Padhan, J and Sudhamalla, B. 2022."Molecular Insights into the Recognition of Acetylated Histone Modifications by the BRPF2 Bromodomain." Biochemistry, 61, 1774-1789
- Kuwik, J; Wagner, S; Sudhamalla, B; Debiec, R and Islam, K. 2022."Hydrophobic Cavity Directed Azide-Acetyllysine Photochemistry for Profiling Non-Histone Interacting Partners of Bromodomain Protein 1." RSC Chemical Biology, 3, 1061-1068
- Roy, A; Barman, S; Padhan, J and Sudhamalla, B. 2021."Engineering an acetyllysine reader with a photocrosslinking amino acid for interactome profiling." Chem. Commun, 57, 9866-9869
- Barman, S; Roy, A; Bardhan, I; Kandasamy, T; Shivani, S and Sudhamalla, B. 2021."Insights into the Molecular Mechanisms of Histone Code Recognition by the BRPF3 Bromodomain." Chem Asian J, 16, 3404-3412
- Sappa, S; Dey, D; Sudhamalla, B and Islam, K. 2021."Catalytic Space Engineering as a Strategy to Activate C-H Oxidation on 5-Methylcytosine in Mammalian Genome." J Am Chem Soc ., 143, 11891
- Wagner, S; Sudhamalla, B; Mannes, P; Sappa, S; Kavoosi, S; Dey, D; Wang, S and Islam, K. 2020."Engineering bromodomains with a photoactive amino acid by engaging 'Privileged' tRNA synthetases." Chem. Commun., 56, 3641
- Kavoosi, S; Sudhamalla, B; Dey, D; Shriver, K; Arora, S; Sappa, S and Islam, K. 2019."Site-and degree-specific C-H oxidation on 5-methylcytosine homologues for probing active DNA demethylation." Chem. Sci, 10, 10550
- Sudhamalla, B; Wang, S; Snyder, V; Kavoosi, S; Arora, S and Islam, K. 2018." Complementary Steric Engineering at the Protein-Ligand Interface for Analogue-Sensitive TET Oxygenases." J. Am. Chem. Soc., 140(32), 10263
- Sudhamalla, B; Dey, D; Breski, M and Islam, K. 2017."A rapid mass spectrometric method for the measurement of catalytic activity of ten-eleven translocation enzymes." Anal Biochem. , 534, 28
- Perell, GT; Mishra, NK; Sudhamalla, B; Ycas, PD; Islam, K and Pomerantz, WCK. 2017."Specific Acetylation Patterns of H2A.Z Form Transient Interactions with the BPTF Bromodomain." Biochemistry, 56(35) , 4607
- Sudhamalla, B; Dey, D; Breski, M; Nguyen, T and Islam, K. 2017."Site-specific azide-acetyllysine photochemistry on epigenetic readers for interactome profiling." Chem Sci. , 8(6) , 4250
- Breski, M; Dey, D; Obringer, S; Sudhamalla, B and Islam, K. 2016."Engineering Biological C-H Functionalization Leads to Allele-Specific Regulation of Histone Demethylases." J. Am. Chem. Soc. , 138 (41) , 13505
- Sudhamalla, B; Kumar, M; Roy, KR; Kumar, RS and Bhuyan, AK. 2013."Cysteine endoprotease activity of human ribosomal protein S4 is entirely due to the C-terminal domain, and is consistent with Michaelis-Menten mechanism." Biochim Biophys Acta., 1830(11), 5342
- Sudhamalla, B; Kumar, M; Kumar, RS; P, Sashi; UM, Yasin; D, Ramakrishna; Rao, PN and Bhuyan, AK. 2013."Enzyme dimension of the ribosomal protein S4 across plant and animal kingdoms." Biochim Biophys Acta., 1830(11), 5335
- M, Yadaiah; Sudhamalla, B; Rao, PN; Roy, KR; D, Ramakrishna; Hussain Syed, G; Ramaiah, KV and Bhuyan, AK. 2013."Arrested cell proliferation through cysteine protease activity of eukaryotic ribosomal protein S4." FASEB J. , 27(2), 803
- Sudhamalla, B; M, Yadaiah; D, Ramakrishna and AK, Bhuyan. 2012."Cysteine protease attribute of eukaryotic ribosomal protein S4." Biochim Biophys Acta., 1820(10), 1535
- S, Sanchita; R, Chauhan; G, Soni; Sudhamalla, B and A, Sharma. 2012."Docking and molecular dynamics studies of peptide inhibitors of ornithine decarboxylase: a rate-limiting enzyme for the metabolism of Fusarium solani." J Biomol Struct Dyn., 31(8), 874
- Mamidala, P; AJ, Wijeratne; S, Wijeratne; K, Kornacker; Sudhamalla, B; LJ, Rivera-Vega; T, Hoelmer A, Meulia; SC, Jones and Mittapalli, O. 2012."RNA-Seq and molecular docking reveal multi-level pesticide resistance in the bed bug." BMC Genomics., 13, 6
- M, Yadaiah; P, Nageswara Rao; Sudhamalla, B; D, Ramakrishna; U, Mahammad Yasin and AK, Bhuyan. 2012."Cloning, Escherichia coli expression, purification, characterization, and enzyme assay of the ribosomal protein S4 from wheat seedlings (Triticum vulgare)." Protein Expr Purif., 81(1), 55
- Sudhamalla, B; Gokara, M; Ahalawat, N; Amooru, DG and Subramanyam, R. 2010."Molecular dynamics simulation and binding studies of beta-sitosterol with human serum albumin and its biological relevance." J Phys Chem B., 114(27), 9054
- Neelam, S; Gokara, M; Sudhamalla, B; Amooru, DG and Subramanyam, R. 2010."Interaction studies of coumaroyltyramine with human serum albumin and its biological importance." J Phys Chem B., 114(8), 3005
- Gokara, M; Sudhamalla, B; Amooru, DG and Subramanyam, R. 2010."Molecular interaction studies of trimethoxy flavone with human serum albumin." PLoS One., 5(1), e8834
- Subramanyam, R; Goud, M; Sudhamalla, B; Reddeem, E; Gollapudi, A; Nellaepalli, S; Yadavalli, V; Chinnaboina, M and Amooru, DG. 2009."Novel binding studies of human serum albumin with trans-feruloyl maslinic acid." J Photochem Photobiol B., 95(2), 81