Supratim Datta

Associate Professor
Dept: Biological Sciences (DBS)
E-mail: supratim [at] iiserkol.ac.in

All Publications:

  1. Konar, Sukanya; Sinha, Sushant K.; Datta*, Supratim and Ghorai*, Pradip Kr.. 2020."Probing the dynamics between the substrate and the product towards glucose tolerance of Halothermothrix orenii ?-glucosidase." Journal of Biomolecular Structure and Dynamics, 0, 1-11
  2. Konar, Sukanya; Sinha, Sushant K.; Datta*, Supratim and Ghorai*, Pradip Kr.. 2020."Investigating the effect of the ionic liquid, 1-ethyl-3-methylimidazolium chloride ([EMIM][Cl]), on the activity and stability of beta-glucosidase." Journal of Molecular Liquids, 306, 112879
  3. Sinha, Sushant K; Das, Shibashis; Konar, Sukanya; Ghorai*, Pradip Kr; Das*, Rahul and Datta*, Supratim. 2020."Elucidating the regulation of glucose tolerance in a beta glucosidase from Halothermothrix orenii by active site pocket engineering and computational analysis." International Journal of Biological Macromolecules, 156, 621-632
  4. Aich, Shritama and Datta, Supratim. 2020."Engineering of a highly thermostable endoglucanase from the GH7 family of Bipolaris sorokiniana for higher catalytic efficiency." Applied Microbiology and Biotechnology, 104, 3935–3945
  5. Singh, Sushant K; Reddy, K Prakash and Datta, Supratim. 2019."Understanding the glucose tolerance of an archaeon beta glucosidase from Thermococcus sp.." Carbohydrate Research, 486, 107835
  6. Konar, Sukanya; Sinha, Sushant K; Datta*, Supratim and Ghorai*, Pradip K. 2019."Probing the Effect of Glucose on the Activity and Stability of a beta glucosidase, An All Atom Molecular Dynamic Simulation Investigation." ACS Omega, 4, 11189-96
  7. Mukherjee, Ishita; Sinha, Sushant K.; Datta*, Supratim and De*, Priyadarsi. 2018."Recyclable Thermoresponsive Polymer beta Glucosidase Conjugate with Intact Hydrolysis Activity." Biomacromolecules, 19, 2286–2293
  8. Goswami, Shubhasish; Das, Shibashis and Datta, Supratim. 2017."Understanding the role of residues around the active site tunnel towards generating a glucose tolerant beta glucosidase from Agrobacterium tumefaciens." Protein Engineering Design and Selection, 30, 523-530
  9. Aich, Shritama; Singh, Ravi K; Kundu, Pritha; Pandey*, Shree P. and Datta*, Supratim. 2017."Genome wide characterization of cellulases from the hemibiotrophic plant pathogen, Bipolaris sorokiniana, reveals presence of a highly stable GH7 endoglucanase." Biotechnology for Biofuels, 10, 135
  10. Sinha, Sushant K; Goswami, Shubhasish; Das, Shibashis and Datta, Supratim. 2017."Exploiting non conserved residues to improve activity and stability of Halothermothrix orenii beta glucosidase." Applied Microbiology and Biotechnology, 101, 1455-1463
  11. Sinha, Sushant K. and Datta, Supratim. 2016."Beta glucosidase from the hyperthermophilic archaeon Thermococcus sp. is a salt tolerant enzyme that is stabilized by its reaction product glucose." Applied Microbiology and Biotechnology, 100(19), 8399–8409
  12. Goswami, Shubhasish; Gupta, Neha and Datta, Supratim. 2016."Using the beta glucosidase catalyzed reaction product glucose to improve the ionic liquid tolerance of beta glucosidases." Biotechnology for Biofuels, 9(72), 1-12
  13. Datta, Supratim. 2016."Recent strategies to overexpress and engineer cellulases for biomass degradation." Current Metabolomics, 4, 14-22
  14. Heins, Richard A; Cheng, X; Nath, S; Deng, K; Bowen, B P; Chivian, D C and Datta, Supratim. 2014."Phylogenomically guided identification of industrially relevant GH1 beta Glucosidases through DNA synthesis and Nanostructure Initiator mass spectrometry." ACS Chemical Biology, 9, 2082–2091
  15. Cheng, G and Datta, Supratim. 2012."Interactions of endoglucanases with amorphous cellulose films resolved by neutron reflectometry and quartz crystal microbalance with dissipation monitoring." Langmuir, 28, 8348-8358
  16. Ouellet, M and Datta, Supratim. 2011."Impact of ionic liquid pretreated plant biomass on S. cerevisiae growth and biofuel production." Green Chemistry, 13, 2743-2749
  17. Zhang, Tao and Datta, Supratim. 2011."Identification of haloalkaliphilic and thermostable cellulase with improved ionic liquid tolerance." Green Chemistry, 13, 2083-2090


  1. Sinha, Sushant K and Datta, Supratim. 2018." Recent advancements in the engineering of ?-Glucosidases for biomass degradation", "Advances in Biofuels Production". Nova Science Inc., New York, , ISBN: 9781536146714